2014
DOI: 10.5214/ans.0972.7531.210204
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Effect of hydro-alcoholic root extract of Plumbago zeylanica l alone and its combination with aqueous leaf extract of Camellia sinensis on haloperidol induced parkinsonism in wistar rats

Abstract: BackgroundHerbal medicines have been used to treat PD in ancient medical systems in Asian countries such as India, China, Japan and Korea based on their own anecdotal or experience-based theories. Mucuna pruriens commonly known asvelvet beans, or cow itch, are used in case of spasms associated with Parkinsonism.PurposeTo investigate the antiparkinsonism activity of hydro alcoholic root extract of P. zeylanica L (PZE) aloneand its combination withaqueous extract of C. sinensis leaves (AECS) in Haloperidol induc… Show more

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Cited by 11 publications
(10 citation statements)
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“…On treatment with MEPAC (200 mg/kg) and MEPAC (400 mg/kg), the levels of GSH and SOD were found to be increased. These results were in conformity with previously conducted studies [30,31]. The histopathological reports show that treatment with MEPAC (200 mg/kg) and MEPAC (400 mg/kg) showed results similar to standard group where the cerebral cortex and hippocampus appeared normal and showed mild proliferation in the region of hippocampus.…”
Section: Nandagopal and Khansupporting
confidence: 92%
“…On treatment with MEPAC (200 mg/kg) and MEPAC (400 mg/kg), the levels of GSH and SOD were found to be increased. These results were in conformity with previously conducted studies [30,31]. The histopathological reports show that treatment with MEPAC (200 mg/kg) and MEPAC (400 mg/kg) showed results similar to standard group where the cerebral cortex and hippocampus appeared normal and showed mild proliferation in the region of hippocampus.…”
Section: Nandagopal and Khansupporting
confidence: 92%
“…(Trevitt et al., 2009; Maj et al., 1990; Juszkiewicz et al., 1994; Juszkiewicz et al., 1995; Mandhane et al., 1997; Konieczny et al., 1999; Jagtap & Inamdar, 2001; Ossowska et al., 2001; Breysse et al., 2002; Moo‐Puc et al., 2003; Ossowska et al., 2003; Rukoyatkina et al., 2003; Wardas et al., 2003; Tanganelli et al., 2004; Ossowska et al., 2005; Zazpe et al., 2006; Lopez et al., 2007; Sibille et al., 2007; Ahemad et al., 2009; Beurrier et al., 2009; Góngora‐Alfaro et al., 2009; Konieczny et al., 2009; Ardashov et al., 2011; Joshi et al., 2011; Trevizol et al., 2011; Lopez et al., 2012; Shyamjith et al., 2012; Goudet et al., 2012; Acuña‐Lizama et al., 2013; Konieczny & Lenda, 2013; Atack et al., 2014; Ittiyavira & Ruby, 2014; Azam, et al., 2009; Zheng et al., 2014; Gmiro et al., 2015; Maurice et al., 2015; Nade et al., 2015; Bhangale & Acharya, 2016; Dhingra & Gahalain, 2016; Basu et al., 2017; Chitra et al., 2017; Gupta et al., 2017; Kumari et al., 2017; Kronbauer et al., 2017; Tian et al., 2017; Yang et al., 2016; Engelhardt et al., 2018; Slee et al., 2008; Saleem et al., 2019; Kabra et al., 2020; Łażewska et al., 2020; Chiu et al., 1981; Schmidt & Bubser, 1989; Schmidt et al., 1991; Kretschmer, 1994; Kretschmer et al.,…”
Section: Resultsmentioning
confidence: 99%
“…The ultimate manifestation of anxiety and fear in the animals is exhibited because of a decrease in motor activity and preference to remain at safer places [19]. Akinesia is a loss of standard motor functions or slowness that causes impaired movement of the muscle, due to the extrapyramidal side effect of the drug [20]. Catalepsy is defined as the failure to correct an externally imposed posture.…”
Section: Discussionmentioning
confidence: 99%