Effect of hydrotropes on solubility and mass transfer coefficient of lauric acid

Kumar, S. Thenesh; Prakash, D. Gnana; Gandhi, N. Nagendra

doi:10.1007/s11814-009-0219-2

Cited by 15 publications

(6 citation statements)

References 21 publications

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“…Alternatively, a polynomial fitting of solubility, incorporating up to the sixth order of hydrotrope concentration, was able to fit the data. 52 This approach may be found firmly upon the MM theory of solutions, yet, as we have previously shown, the higher the order the increasingly more cumbersome the theoretical expression becomes, hence is difficult to obtain physical insights. 32 In contrast to these previous models, our theory can now describe the entire region of the solubility curve with clear physical insights.…”

Section: Discussionmentioning

confidence: 99%

The origin of cooperative solubilisation by hydrotropes

Shimizu

Matubayasi

2016

Phys. Chem. Chem. Phys.

109

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The signature of hydrotropic solubilisation is the sigmoidal solubility curve; when plotted against hydrotrope concentration, solubility increases suddenly after the minimum hydrotrope concentration (MHC), and reaches a plateau at higher hydrotrope concentrations. This sigmoidal curve is characteristic of cooperative phenomena, yet the true molecular basis of hydrotropic cooperativity has long remained unclear. Here we develop a theory, derived from the first principles of statistical thermodynamics using partially-open ensembles, to identify the origin of hydrophobic cooperativity. Our theory bears a close resemblance to the cooperative binding model used for protein-ligand binding. The cause of cooperativity is the enhancement of the hydrotrope m-body interaction induced by the presence of the solute; m can be estimated from the experimental solubility data.

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Section: Discussionmentioning

confidence: 99%

The origin of cooperative solubilisation by hydrotropes

Shimizu

Matubayasi

2016

Phys. Chem. Chem. Phys.

109

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“…For rapid and accurate results, the concept of hydrotropy can be coupled with spectrophotometry and chromatography. This article provides insight into the application of hydrotropy in various applications in medical and pharmaceutical applications [13][14][15][16].…”

Section: Hydrotropismmentioning

confidence: 99%

“…Many time affinities-based mechanisms are used. The concept of hydrotropism plays very significant role in drug delivery [5][6][7][8].…”

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confidence: 99%

Drug Delivery and Hydrotropism

2020

International Journal of Advanced Research in Chemical Science

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INTRODUCTION Biotechnology and Drug Delivery SystemBiotechnology is one of the important domains in chemical engineering. As they say, the best processing plant possible is our body system. Almost all the mechanical operations, Reactions (biochemical), separations, downstream processing occur in our body system. Kinetics of biological reactions, enzyme kinetics, gene therapy, recombinant technology, drug delivery are some of the topics in biotechnology. Also, for chemical engineering courses, biotechnology is one of the electives in final year students in India in many universities. It is natural for a chemical engineer to take interest in biotechnology. Drug delivery systems play major role in the utilization of drugs. The mode of injection of the drug plays a major role is deciding ease of drug delivery. For the pharmaceutical compounds, it is very important to have proper drug delivery system which will keep their effect intact during the transportation in side our body [1][2][3][4]. THE MECHANISMThe concentration of the drug inside the body needs to be maintained above certain value to get effect out of the drug. For this purpose, the drug intake is given three to four times a day to the patient. The ability of the person to follow the drug intake schedule and the severity of the drug requirement decides mode of drug delivery which in turn has major role to play in drug transportation. Whenever drug is injected in the bodies, it spreads across various parts of bodies. Its presence is normally undesired in all parts of body. Many investigations are reported on the localized and specific drug delivery systems. In any case, this aspect reduces the amount of drug required also. Localized and specific drug delivery has advantages such as fast and rapid effects and immediate and fast relief for the patient. Diffusion plays very important role in drug delivery. Many time affinities-based mechanisms are used. The concept of hydrotropism plays very significant role in drug delivery [5][6][7][8]. Solubility of a DrugThe solubility of the compound in the solvent plays important role in utilization of the compound for drug delivery. Many common drugs are injected into body by oral route through gastrointestinal Abstract: Drug delivery systems play major role in the utilization of drugs. The mode of injection of the drug plays a major role is deciding ease of drug delivery. For the pharmaceutical compounds, it is very important to have proper drug delivery system which will keep their effect intact during the transportation in side our body. The concentration of the drug inside the body needs to be maintained above certain value to get effect out of the drug. For this purpose, the drug intake is given three to four times a day to the patient. The ability of the person to follow the drug intake schedule and the severity of the drug requirement decides mode of drug delivery which in turn has major role to play in drug transportation. The solubility of the compound in the solvent plays important role in utilization of the co...

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“…Hydrotropic extraction relies mainly on the addition of enough hydrotropes in the solution. The different hydrotropes can be identified by their formula -sodium salicylate, cumene sulfonate, vitamin C, sodium benzoate, and sodium xylene sulfonate being some examples of hydrotropes [54][55][56][57][58][59] -and they are characterized by their MHC. Different methods of hydrotropic extraction exist.…”

Section: Principles and Processmentioning

confidence: 99%

Water as Green Solvent for Extraction of Natural Products

Petigny

Özel

Périno

et al. 2015

Green Extraction of Natural Products

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IntroductionWater is the most abundant molecule on the earth, covering 70% of its surface. Life processes on this planet are crucially dependent on the presence of water. It is often recognized that water has tremendous benefits as a green extraction solvent because it is not only inexpensive and environmentally benign but it is also nonflammable and nontoxic, providing opportunities for clean processing and pollution prevention. The water molecule contains three nuclei, one modestly heavy (oxygen), and two light ones (hydrogen). Because of water's electronic structure, the oxygen atom has a slight negative charge on it and the hydrogen atoms have a slightly positive charge [1]. When water molecules are closed together, their positive and negative regions are attracted, these attractive forces are known as hydrogen bonds. The energy associated with a hydrogen bond is 8-40 kJ/mol. The O-H bond lengths are 0.9572 Å and the average HOH bond angle is 104.52 ∘ , slightly smaller than the tetrahedral angle (109.5 ∘ ). The molecule is very small with a hard sphere diameter of 2.75 Å. The smallness of the water molecule has important consequences for the hydration of solutes. The contours of the total electron density in the HOH plane of the water molecule indicate a shape not far from spherical. The water molecule has a dipole moment of 1.85 D with two partial positive charges on the hydrogen atoms and a single zone of negative charge on the oxygen atom.It is well known that water molecules are strongly associated in the liquid phase by H-bonding. Hydrogen bonds result dominantly from electrostatic interactions with a light contribution of covalent bond formation. The H-bond interactions in liquid water constitute a 3-D H-bond network with localized and structured clustering. Therefore, the liquid structure is not determined by hard-core repulsions between the individual water molecules but rather by intermolecular and directional H-bonding. The broad variation of H-bond angles further demonstrates the noncrystalline arrangement of the water molecules and appears to indicate that some bond angle distortion in the H-bonds is rather easily allowed in the liquid. It is important to recognize that intermolecular interaction Green Extraction of Natural Products: Theory and Practice, First Edition. Edited by Farid Chemat and Jochen Strube.

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Effect of hydrotropes on solubility and mass transfer coefficient of lauric acid

Cited by 15 publications

References 21 publications

The origin of cooperative solubilisation by hydrotropes

The origin of cooperative solubilisation by hydrotropes

Drug Delivery and Hydrotropism

Water as Green Solvent for Extraction of Natural Products

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