Effect of hydroxyurea on sperm count, motility and morphology in adult men with sickle cell or myeloproliferative disease

Grigg, Andrew

doi:10.1111/j.1445-5994.2006.01290.x

Cited by 63 publications

(55 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As it was also mentioned, the literature shows that HU affects sperm in different ways [22,23]. The present study in Drosophila indicates that the female gametes are also affected by HU treatment.…”

Section: Discussionsupporting

confidence: 57%

“…However, HU treatment presents side effects that cause medical concern, mainly in long-term treatments. In addition to possible teratogenic, mutagenic and carcinogenic effects [20,21], there are concerns about decrease of reproductive capacity, and developmental problems [22,23]. This concern is reinforced by the fact that HU was included in the list of substances to be evaluated as to the potential for adverse effects on reproduction or development of the National Toxicology Program from US Department of Health and Human Services [24].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Impact of the Medicine Hydroxyurea on Reproduction and Development, Using Drosophila Melanogaster as a Model Organism

Rangel¹,

Patarro

Manzato³

et al. 2014

TOPHJ

View full text Add to dashboard Cite

Abstract:The clinical efficacy of oral hydroxyurea (HU) in the treatment of the sickle cell disease (SCD) is already proven. However, side-effects on reproduction and development still cause concerns, mainly in long term treatments. We used Drosophila melanogaster as a model organism in the study of this subject. This species has been considered favorable for studying human diseases and responses to drugs because both organisms share more than 50% of the genes for disease and exhibit a very similar drug metabolism. In addition, D. melanogaster allows laboratory approaches that are not possible in humans. We analyzed the impact of the concentrations HU 0.1 and HU 0.25 on productivity, oviposition rate, emergence period duration, mortality and development time from egg to adult. HU affected all these traits, showing dose dependence. The frequency of mating, and duration of premating and mating times of flies were also analyzed in treatments with HU 0.25. Considering all the traits, the treatments decreased the productivity, oviposition rate and frequency of mating, and increased the emergence period duration, mortality rate from egg to adult and development time. The premating and mating times duration were affected in a more complex way. On the basis of the knowledge that HU affects DNA synthesis and repair, and other data available in the literature, we raised hypotheses to explain the present observations. The results and hypotheses suggested new approaches for further studies of particular and important aspects. In general, this study reinforces the validity of the concern with HU side-effects.Keywords: Emergence period duration, impaired effect of hydroxyurea, mortality from egg to adult, number of progeny, oviposition rate.

show abstract

Section: Discussionsupporting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Impact of the Medicine Hydroxyurea on Reproduction and Development, Using Drosophila Melanogaster as a Model Organism

Rangel¹,

Patarro

Manzato³

et al. 2014

TOPHJ

View full text Add to dashboard Cite

show abstract

“…Antidepressants have well established sexual side effects including changes in libido, impotence, priapism, and ejaculatory dysfunction. There are also reports of reversible azospermia associated with hydroxyurea [22,23].…”

Section: Cutaneous Side Effect: Desquamating Pruritic Rashmentioning

confidence: 99%

Idiosyncratic Side Effects of Hydroxyurea in Patients with Sickle Cell Anemia

Singh¹

2013

J Blood Disord Transfus

View full text Add to dashboard Cite

“…Sickle-cell-transgenic mice have hypogonadism at baseline. After treatment with HU, the mice showed decreased testicular size and increased sperm abnormalities compared with normal mice [33].…”

Section: Hydroxyurea (Hu) and Fertility In Men With Scdmentioning

confidence: 99%

Infertility Issues in Men with Sickle Cell Disease

AlDallal

2017

IPCB

View full text Add to dashboard Cite

Patients with sickle cell disease (SCD), especially males, face a key problem in the form of infertility. Apart from low serum testosterone, abnormalities involving accessory sex organs are also observed in these patients. Infertility is a known complication among males with SCD, and it comes about due to reasons such as impotence, relative primary gonadal failure, priapism, and delayed or impaired sexual development. Infertility manifests due to multiple causes, including primary gonadal failure (hypogonadism), erectile dysfunction (ED) as a result of priapism, sperm abnormalities, and delayed or impaired sexual development. The ejaculate volume, sperm density, sperm motility, and normal sperm morphology were significantly reduced in these patients as compared with normal patients. Most importantly, primary testicular failure is marked by low levels of testosterone and infertility results mainly from diseases or conditions that affect and destroy the testis. The low levels of testosterone lead to fertility reduction, which is aggravated by impotence, secondary to earlier priapism. Studies among mice have shown that increased doses of HU increase testicular germ cell apoptosis, decrease sperm count, induce testicular atrophy, increase abnormal sperm morphology, and decrease sperm motility. A multifactorial etiology is responsible for impaired male fertility and it includes sperm abnormalities, ED, hypogonadism, and effect of therapy on sperm function. This paper summarizes some clinical manifestations which play an important role in the development of infertility among men with SCD. The author suggests that prospective studies among males with SCD should be carried out using various end points to determine cellular and functional impairment in fertility.

show abstract

Effect of hydroxyurea on sperm count, motility and morphology in adult men with sickle cell or myeloproliferative disease

Cited by 63 publications

References 9 publications

Impact of the Medicine Hydroxyurea on Reproduction and Development, Using Drosophila Melanogaster as a Model Organism

Impact of the Medicine Hydroxyurea on Reproduction and Development, Using Drosophila Melanogaster as a Model Organism

Idiosyncratic Side Effects of Hydroxyurea in Patients with Sickle Cell Anemia

Infertility Issues in Men with Sickle Cell Disease

Contact Info

Product

Resources

About