Effect of Hyperbaric Oxygen Therapy to Improve Serum Albumin for Patients with Diabetic foot Ulcers

Irawan, Hendry; Semadi, I Nyoman; Devi, Anita

doi:10.13005/bpj/1409

Cited by 4 publications

(10 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Diabetes mellitus (DM) is a chronic disease caused by inadequate insulin production, or when insulin cannot be used effectively. This results in elevated blood sugar levels causing damage to the heart, blood vessels, eyes, kidneys, and nerves in longstanding uncontrolled DM [1], [2]. In patients with DM, the most common complications in blood vessels are macroangiopathy, neuropathy, immunosuppression that facilitate inflammation, ischemia, infection, and cell death [2], [3].…”

Section: Introductionmentioning

confidence: 99%

The Role of VEGF and TNF-Alpha on Epithelialization of Diabetic Foot Ulcers after Hyperbaric Oxygen Therapy

Semadi¹

2019

Open Access Maced J Med Sci

View full text Add to dashboard Cite

BACKGROUND: Around 15-25% of diabetes mellitus (DM) patients will develop diabetic foot ulcers (DFUs) with high morbidity, many studies have been proposed to search the most effective healing techniques. AIM: This study was conducted to demonstrate the ability of hyperbaric oxygen therapy (HBOT) as a complementary therapy in DFUs healing through raising vascular endothelial growth factor (VEGF) levels and suppressing tumour necrosis factor-alpha (TNF-α). METHODS: All patients received the same treatment including wound debridement and wound care, but the patients in the HBOT group, breathed 100% oxygen at 2.4 ATA for 90 minutes in total of 20 sessions (four weeks). RESULT: There were 32 diabetic patients with DFUs Wagner 3-4. VEGF levels after four weeks of HBOT was significantly elevated compared to the control group (p = 0.013). The effect size of VEGF levels was p = 0.005. TNF-α levels after four weeks of therapy were decreased (p = 0.01). Faster epithelialization is seen in the HBOT group (p < 0.001). We also performed path analysis, HBOT had a significant effect on the epithelialization (p < 0.001) and VEGF levels affected the epithelialization process (p = 0.042). CONCLUSION: HBOT administration leads to increased VEGF levels, decreased TNF-α levels, and accelerated wound healing of DFUs patients. HBOT directly aids epithelialization and indirectly through VEGF upsurge and TNF-α downturn.

show abstract

Section: Introductionmentioning

confidence: 99%

The Role of VEGF and TNF-Alpha on Epithelialization of Diabetic Foot Ulcers after Hyperbaric Oxygen Therapy

Semadi¹

2019

Open Access Maced J Med Sci

View full text Add to dashboard Cite

show abstract

“…19 The impact of hyperbaric oxygen therapy on serum albumin has never been explained in prior studies. 14 In this study, the increased serum albumin level in G3 group was likely due to the antioxidant function possessed by albumin. Albumin becomes primary circulating antioxidant in the body, main extracellular source of thiols and reduced sulfhydryl group, which then act as scavengers of reactive oxygen and nitrogen species.…”

Section: Serum Albumin Levels Of Oral Candidiasis Immunosuppressed Rats Treated With Hyperbaric Oxygenmentioning

confidence: 62%

“…This elevation of serum albumin levels was in line with a previous study which showed that the administration of hyperbaric oxygen therapy could significantly increase serum albumin levels in patients with diabetic foot ulcers. 14 Several studies revealed…”

Section: Discussionmentioning

confidence: 99%

“…12 This therapy also reported having a hepatoprotective effect in hepatocellular necrosis which was caused by excessive administration of acetaminophen in rats model. 18 Hyperbaric oxygen therapy could increase the level of dissolved oxygen transported to the tissues systemically, 14 moreover, oxygen transported to the injured liver will also increase. Serum albumin is the most substantial plasma protein in the body, about 50% of the total protein, which is mainly synthesized in the liver.…”

Section: Serum Albumin Levels Of Oral Candidiasis Immunosuppressed Rats Treated With Hyperbaric Oxygenmentioning

confidence: 99%

“…12 Hyperbaric oxygen therapy not only able to increase tissue oxygen level, but also could elevate growth factors and reduce inflammatory cytokines. 14 Reactive oxygen species derived from cyclic periods of hyperbaric and normoxic oxygen will affect the release of multiple growth factors by transducing signaling pathways, including those that lead to angiogenesis. 20 Giving hyperbaric oxygen therapy will modulate Nitric Oxide (NO) to enhance expression of multiple growth factors such as Vascular Endothelial Growth Factor (VEGF) and Fibroblast Growth Factor (FGF) which able to trigger neovascularization and angiogenesis for healing injured tissue.…”

Section: Serum Albumin Levels Of Oral Candidiasis Immunosuppressed Rats Treated With Hyperbaric Oxygenmentioning

confidence: 99%

See 2 more Smart Citations

Serum Albumin Levels of Oral Candidiasis Immunosuppressed Rats Treated With Hyperbaric Oxygen

Pargaputri¹,

Andriani²

2020

ijihs

View full text Add to dashboard Cite

Objective: To investigate serum albumin levels in oral candidiasis immunosuppressed rats treated with hyperbaric oxygen. One of the predisposing factors for oral candidiasis was the use of immunosuppressive drugs continuously. It can also affect the work of the liver because it’s one of the organs responsible for drug metabolism. Hyperbaric oxygen therapy was used not only to suppressing fungal infections, but also to improve liver function by evaluating the serum albumin levels. Methods: This study used a post-test only control group design. Fifteen Wistar rats were divided into 3 groups(n=5/3): G1 (healthy group), G2 (oral candidiasis immunosuppressed rats group without hyperbaric oxygen therapy), and G3 (oral candidiasis immunosuppressed rats group with hyperbaric oxygen therapy). G2 and G3 groups were immunosuppressed by giving dexamethasone 0,5mg/day/rat orally for 14 days, added with tetracycline 1 mg/day/rat. Hyperbaric oxygen therapy was given to the G3 group in 5 days. Blood serum of rats in all groups was taken to calculate albumin levels. Results: The average value of albumin levels in G2 group showed a decrease compared to the G1 group, while G3 showed the highest level. One way Anova test showed a significant difference among groups (p<0,05). To compare the difference between each group we used LSD test and showed a significant difference (p<0,05) between G1 compared to G2, G1 compared to G3, and G2 compared to G3. Conclusion: Liver albumin levels of oral candidiasis immunosuppressed rats treated with hyperbaric oxygen therapy showed higher levels than those without therapy.

show abstract

Biochemical aspects of effects of mesenchymal stem cell treatment in chronic wounds progressive healing

et al. 2022

View full text Add to dashboard Cite

Effect of Hyperbaric Oxygen Therapy to Improve Serum Albumin for Patients with Diabetic foot Ulcers

Cited by 4 publications

References 0 publications

The Role of VEGF and TNF-Alpha on Epithelialization of Diabetic Foot Ulcers after Hyperbaric Oxygen Therapy

The Role of VEGF and TNF-Alpha on Epithelialization of Diabetic Foot Ulcers after Hyperbaric Oxygen Therapy

Serum Albumin Levels of Oral Candidiasis Immunosuppressed Rats Treated With Hyperbaric Oxygen

Biochemical aspects of effects of mesenchymal stem cell treatment in chronic wounds progressive healing

Contact Info

Product

Resources

About