Effect of hyperbaric oxygen therapy combined with autologous platelet concentrate applied in rabbit fibula fraction healing

Neves, Paula; Abib, Simone de Campos Vieira; Neves, Rogerio Fagundes; Pircchio, Oronzo; Saad, Karen Ruggeri; Saad, Paulo Fernandes; Simões, Ricardo Santos; Moreira, Márcia Bento; Laurino, Cristiano Frota de Souza

doi:10.6061/clinics/2013(09)11

Cited by 15 publications

(8 citation statements)

References 31 publications

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“…Neves et al compared a control group to combined and separate PRP and HBO in the treatment of osteomyelitis in his experimental study. The combination therapy was reported as successful in terms of the activity of osteoblasts, osteocytes, and collagen [24]. In the present study, we found that separate treatments were useful for collagen fiber regeneration and dermal angiogenesis, but combination therapy was more successful for wound healing.…”

Section: Discussionsupporting

confidence: 53%

Effects of hyperbaric oxygen therapy combined with platelet-rich plasma on diabetic wounds: an experimental rat model

Yümün¹,

Kahaman²,

Kahaman³

et al. 2016

aoms

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IntroductionHyperbaric oxygen and platelet-rich plasma are used in the treatment of diabetic wounds. The aim of this study is to evaluate the effects of hyperbaric oxygen therapy and autologous platelet concentrates in healing diabetic wounds.Material and methodsThirty-six female Wistar albino rats were used in this study. Diabetes mellitus was induced chemically with an intraperitoneal injection of streptozotocin. The rats were divided into a control group, a hyperbaric oxygen group, a platelet-rich plasma group, and a combined therapy group. Platelet-rich plasma was applied just after the creation of the wound; hyperbaric oxygen treatment was carried out daily over 7 days. Wound healing was evaluated according to four parameters: ulcerations, epidermal thickness, density of dermal collagen fibers, and proliferation of dermal blood vessels.ResultsThe number of active ulcers in the combined therapy group was fewer than in the control group (p = 0.039), and the wound area was greatest in controls (p < 0.001). The epidermal thickness in platelet-rich plasma and combined therapy groups was non-significantly greater than in the control group (p = 0.097 and p = 0.074, respectively). The amount of fibrous collagen in these two groups was greater than in the control group (p = 0.002).ConclusionsCombined hyperbaric oxygen and platelet-rich plasma therapy was found to be successful in diabetic wound healing. The combination therapy had no additive effect in terms of angiogenesis and the development of new collagen fibers.

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Section: Discussionsupporting

confidence: 53%

Effects of hyperbaric oxygen therapy combined with platelet-rich plasma on diabetic wounds: an experimental rat model

Yümün¹,

Kahaman²,

Kahaman³

et al. 2016

aoms

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“…Additionally, a significant bone formation was observed when PRP was used with biphasic CaP or PGA containing BMP-2 [ 64 , 67 ]. A different application was proposed by Paulo et al, which treated rabbit fibula fracture with PRP and daily hyperbaric oxygen therapy sessions, with promising results [ 75 ]. However, several studies found opposite outcomes [ 76 ] compared to those just quoted, in particular, when PRP was used in association with ceramic [ 77 – 80 ], metallic [ 81 ], or composite materials [ 82 ].…”

Section: The Role Of Prp In the Regeneration Of Bonementioning

confidence: 99%

New and Emerging Strategies in Platelet-Rich Plasma Application in Musculoskeletal Regenerative Procedures: General Overview on Still Open Questions and Outlook

Salamanna

Veronesi

Maglio

et al. 2015

BioMed Research International

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Despite its pervasive use, the clinical efficacy of platelet-rich plasma (PRP) therapy and the different mechanisms of action have yet to be established. This overview of the literature is focused on the role of PRP in bone, tendon, cartilage, and ligament tissue regeneration considering basic science literature deriving from in vitro and in vivo studies. Although this work provides evidence that numerous preclinical studies published within the last 10 years showed promising results concerning the application of PRP, many key questions remain unanswered and controversial results have arisen. Additional preclinical studies are needed to define the dosing, timing, and frequency of PRP injections, different techniques for delivery and location of delivery, optimal physiologic conditions for injections, and the concomitant use of recombinant proteins, cytokines, additional growth factors, biological scaffolds, and stems cells to develop optimal treatment protocols that can effectively treat various musculoskeletal conditions.

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“…Another set of positive results with the combination of PRP and HBO was achieved by Neves et al, [35] who showed an increased healing process in the bones of rabbits with fibula defects via the combined application of HBO and autologous platelet concentrates (APCs). Neves et al [35] showed an enhanced percentage of collagen and decreased lesion thickness with the combined use of HBO and APC as compared to the control group, APC group, and HBO group.…”

Section: Discussionmentioning

confidence: 99%

Regenerative effects of hyperbaric oxygen therapy and platelet-rich plasma on the osteochondral defects of rats

et al. 2020

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This study aims to investigate the effects of hyperbaric oxygen (HBO) therapy and platelet-rich plasma (PRP) on the regeneration of osteochondral defects of the rats, and the synergistic effect of this combined treatment. Materials and methods: This randomized, controlled, and interventional animal study was conducted between May 2014 and August 2014 Osteochondral regeneration was evaluated in four treatment groups (control, PRP, HBO, and HBO+PRP groups) at the 30 th day after iatrogenic injury. Thirty-two female Wistar albino rats (weighing 248-305 g) underwent arthrotomy and osteochondral surgery on left knees. The regenerations of defects were then examined histologically by the modified version of O'Driscoll score. Results: Groups that were treated with either HBO or PRP alone regenerated significantly better than the control group (p=0.01), while no significant difference was found between the HBO-and PRP-treated groups (p>0.05). The defects in group 4 (treated with both HBO and PRP) regenerated significantly better than the control group, the HBO-treated group alone, and the PRP-treated group alone (p=0.01). Conclusion: The results of this study showed a synergistic effect of HBO and PRP on knee cartilage regeneration. However, the possible underlying mechanisms should be the subject of future researches. The aggregation and activation of growth factors released from platelets whose activation is increased in the hyperbaric environment may explain this effect. This may result in a better regeneration than the effect of PRP or HBO alone.

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Effect of hyperbaric oxygen therapy combined with autologous platelet concentrate applied in rabbit fibula fraction healing

Cited by 15 publications

References 31 publications

Effects of hyperbaric oxygen therapy combined with platelet-rich plasma on diabetic wounds: an experimental rat model

Effects of hyperbaric oxygen therapy combined with platelet-rich plasma on diabetic wounds: an experimental rat model

New and Emerging Strategies in Platelet-Rich Plasma Application in Musculoskeletal Regenerative Procedures: General Overview on Still Open Questions and Outlook

Regenerative effects of hyperbaric oxygen therapy and platelet-rich plasma on the osteochondral defects of rats

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