2005
DOI: 10.1016/j.brainres.2005.02.049
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Effect of hyperbaric oxygenation on intracranial pressure elevation rate in rats during the early phase of severe traumatic brain injury

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Cited by 30 publications
(20 citation statements)
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“…These mechanisms have been demonstrated in both experimental and clinical investigations and include improved oxidative metabolism and mitochondrial function and reductions in intracranial hypertension, apoptosis, neuroinflammation, and free radical-mediated damage. 9,38,39,41,[44][45][46]50,52,[58][59][60][61]65 The results of the present randomized clinical trial help to support these findings.…”
Section: Mechanism Of Hbomentioning
confidence: 56%
“…These mechanisms have been demonstrated in both experimental and clinical investigations and include improved oxidative metabolism and mitochondrial function and reductions in intracranial hypertension, apoptosis, neuroinflammation, and free radical-mediated damage. 9,38,39,41,[44][45][46]50,52,[58][59][60][61]65 The results of the present randomized clinical trial help to support these findings.…”
Section: Mechanism Of Hbomentioning
confidence: 56%
“…[24][25][26][27][28] The primary histologic focus of many of these investigations, however, has been cortical lesion volumes and neuronal injury. Recently, Lafrenaye and associates 26 investigated axonal injury in a central fluid percussion rat model of TBI with elevations in ICP.…”
Section: Introductionmentioning
confidence: 99%
“…Studies of HBO in experimental models of TBI have shown several neuroprotective effects Palzur et al, 2008;Rogatsky et al, 2005;Vlodavsky et al, 2006;Voigt et al, 2008;Wang et al, 2010;Zhou et al, 2007), resulting in reduced mortality and improved neurological outcomes. Nevertheless, HBO is not yet ready to be implemented in clinical practice, as a clear benefit for patients with TBI remains to be proven.…”
Section: Hyperbaric Oxygen Treatmentmentioning
confidence: 99%
“…In vivo imaging and other techniques such as cerebral microdialysis have revealed new insights into the effects of hyperoxia on brain metabolism, and experimental results of this therapeutic approach have been promising (Nortje et al, 2008;Reinert et al, 2004, Rockswold et al, 2010Rogatsky et al, 2005;Tolias et al, 2004;Vlodavsky et al, 2006;Wang et al, 2010). Nevertheless, a clear benefit for patients must be proven before this therapeutic strategy can be used in clinical practice.…”
Section: Introductionmentioning
confidence: 97%