Effect of immobilized bone morphogenic protein 2 coating of titanium implants on peri‐implant bone formation

Abstract

The aim of the present study was to test the hypothesis that immobilization of bone morphogenic protein (BMP2) on the surface of titanium implants can enhance peri-implant bone formation. Ten adult female foxhounds received experimental titanium screw implants in the mandible 3 months after removal of all premolar teeth. Three types of implant surfaces were evaluated in each animal: (i) implants with machined titanium surface, (ii) implants coated with collagen I, (iii) implants coated with collagen I, chondroitin sulphate (CS) and BMP2. Peri-implant bone regeneration was assessed using histomorphometry after 1 and 3 months in five dogs each by measuring bone-implant contact (BIC) and the volume density of the newly formed peri-implant bone (BVD). After 1 month, there was no significant enhancement in BIC values but volume density of the newly formed peri-implant bone was significantly higher in the two groups of coated implants. No significant difference was found between collagen and BMP2 coating. After 3 months, BIC was significantly higher in both collagen and BMP2-coated implants compared with implants with machined surfaces. Peri-implant BVD was also significantly increased in coated implants in comparison with machined surfaces. It was concluded that collagen coating of dental screw implants can enhance BIC and peri-implant bone formation. Addition of BMP2 does not increase peri-implant bone formation in the present application.

A systematic review and meta‐analysis on the influence of biological implant surface coatings on periimplant bone formation

“…Ramazanoglu et al 24 X (*) X (**) X (*/**) 17. Schliephake et al 36 X (**) X (*) X (*/****) 18. Schliephake et al 9 X (*/**) X (*) X (**) X (*/****) 19.…”

“…Schliephake et al 22 X (*) X (*) X (*) 21. Schliephake et al 36 X (*) X (**) X (*) 22. Schliephake et al 26 X (*) X (*/**) X (*) 23.…”

“…For these 23 CaP BMP-2/VEGF-126 Pig Skull 7. Schliephake et al 36 BMP-2 Collagen 1 1 CS Dog Mandible 8. Schliephake et al 9 BMP-2 RGD Collagen 1 1 CS Dog Mandible 9.…”

“…Schliephake et al 22 HA Collagen 1 Dog Mandible 11. Schliephake et al 36 RGD Collagen 1 Dog Mandible 12. Schliephake et al 26 HA 10,19,37 BMP-2 Dog Mandible Table III shows 19 studies with its surface components, animal models, and implant location.…”

“…Also, it is possible that GF activity is reduced due to the immobilization process. 9,10,15,16,19,[23][24][25]28,[35][36][37] The same considerations apply to the other growth factors used (Table III), perhaps even to a greater degree as their effects on bone growth can be expected to be generally lower than that of BMP. 38 There was only one exception to the negligible effect of GF on BIC that can be seen if only pig models are considered (see later).…”