1997
DOI: 10.1016/s0168-8278(97)80105-5
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Effect of immunosuppression on composition of quasispecies population of hepatitis C virus in patients with chronic hepatitis C coinfected with human immunodeficiency virus

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Cited by 72 publications
(70 citation statements)
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“…HCV quasispecies complexity and diversity have been examined in relation to HIV-related immunosuppression, [29][30][31] patient response to interferon-based treatment, 8,[32][33][34][35][36][37] response to liver transplantation, 9,38-41 and in patients with alcoholism 18,42 or hemophilia. 43 These studies have generated conflicting results.…”
Section: Discussionmentioning
confidence: 99%
“…HCV quasispecies complexity and diversity have been examined in relation to HIV-related immunosuppression, [29][30][31] patient response to interferon-based treatment, 8,[32][33][34][35][36][37] response to liver transplantation, 9,38-41 and in patients with alcoholism 18,42 or hemophilia. 43 These studies have generated conflicting results.…”
Section: Discussionmentioning
confidence: 99%
“…44 Despite the fact that HIV/HCV coinfection is common and may have grave clinical consequences, few studies have analyzed factors affecting HCV quasispecies in this setting. Two different studies found correlation between CD4Ï© cell count and HCV diversity, assessed as genetic distance, 29,30 but in a third study correlation was statistically not significant. 31 No relationship was found between CD4Ï© cell count and quasispecies complexity in any of these 3 reports.…”
Section: Discussionmentioning
confidence: 89%
“…In the few studies that were published, the number of analyzed patients was small and the role of associated factors could not be properly analyzed. [29][30][31] The current study is the first systematic analysis of quasispecies complexity and dynamics in a large cohort of HIV-positive women taking into account the impact of multiple epidemiological factors and HAART.…”
Section: H Epatitis C Virus (Hcv) Coinfection Is Commonmentioning
confidence: 99%
“…In addition, HIV-1 co-infection seems to impact the quasispecies complexity exhibited by HCV. Both an increase and a decrease of quasispecies heterogeneity has been described, when compared to HCV mono-infected patients (Sherman et al, 1996;Toyoda et al, 1997). In spite of the conflicting results, many reports suggest a relatively low level of HCV quasispecies diversity before HAART, and an increase in diversity after prolonged treatment, principally due to a significant increase in both synonymous and non-synonymous substitution rates in the hypervariable region 1 of HCV E2 (Bernini, et al, 2011).…”
Section: Hiv Co-infectionmentioning
confidence: 99%