Effect of induced sublethal intoxication with neonicotinoid insecticides on Egyptian toads (Sclerophrys regularis)

Saad, Enas; Elassy, Nehal; Salah-Eldein, Ahmed

doi:10.1007/s11356-021-15976-y

Cited by 8 publications

(7 citation statements)

References 53 publications

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“…Consistently with this idea, we observed infiltration of lymphocytes in the liver parenchyma in the present study. These results coincide with the analyses reported on fish [63] and frogs [57] exposed to insecticides, and they may be due to atrazine's ability to induce an immune response. In addition, lymphocyte infiltration is related to inflammation, edema, fibrosis, and liver degeneration [63].…”

Section: Discussionsupporting

confidence: 90%

“…Organisms may undergo hematological changes to cope with pollutant stress [36,40] after an inflammatory process [63]. In this sense, liver damage caused by atrazine could increase susceptibility to diseases, as occurs in fish living in polluted environments [64], because melanomacrophages act as a defensive system and trap antigens for lymphoid cells in fish and frogs [57]. Consistently with this idea, we observed infiltration of lymphocytes in the liver parenchyma in the present study.…”

Section: Discussionsupporting

confidence: 87%

“…Our results demonstrated an increase in the number of melanin-bearing melanomacrophage centers in the livers of L. spectabilis. Various works have determined that some pollutants increase melanin synthesis in frogs [56], toads [57], and fish [58] exposed to pesticides. The results of these works show that atrazine suppresses nitric oxide [59], and melanomacrophages release nitric oxide [60].…”

Section: Discussionmentioning

confidence: 99%

“…Such histological changes in the liver and erythrocyte cytotoxicity in individuals exposed to atrazine Gesaprim ® may contribute to amphibian population declines. As such, it is essential to consider the physicochemical characteristics of herbicides to know their effects on wild species, especially under natural conditions [57]. The use of atrazine must be regulated in Mexico.…”

Section: Discussionmentioning

confidence: 99%

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Cytotoxic Effects of the Atrazine Herbicide on Erythrocytes and Liver Damage in Lithobates spectabilis

Méndez-Tepepa,

Hernández-Pérez,

Juárez-Santacruz

et al. 2023

Fishes

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In Mexico, atrazine is one of the herbicides most widely authorized and used in different irrigation districts. Atrazine is a herbicide that contaminates aquatic systems. Previous studies have shown that atrazine causes damage to red blood cells and liver tissue in different aquatic species, including abnormalities in melanomacrophages. However, more information on amphibians is needed, since most of these studies have been done on fish. Furthermore, no study has determined the effect of atrazine on species native to Mexico. Therefore, in this study, we asked what the effects of atrazine are on the erythrocytes and melanomacrophages of the liver in the male frog (Lithobates spectabilis). In the present study, we analyzed (1) the cytotoxicity of atrazine using the micronucleus test, (2) the area of melanomacrophage centers and the presence of melanin, and (3) the characterization of liver damage using histological techniques. Our results show that atrazine is cytotoxic to erythrocytes, increases the area of and melanin presence in melanomacrophage centers, and causes liver damage in male L. spectabilis. Therefore, hepatotoxicity and cytotoxicity are indicators of environmental stress. We suggest monitoring Mexico’s aquatic systems and further analyzing atrazine effects and other pollutants on native species.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Cytotoxic Effects of the Atrazine Herbicide on Erythrocytes and Liver Damage in Lithobates spectabilis

Méndez-Tepepa,

Hernández-Pérez,

Juárez-Santacruz

et al. 2023

Fishes

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“…After assessing for inclusion (Figure S1), we extracted 2,012 effect sizes from 86 studies (Acquaroni et al, 2021; Anguiano et al, 2001; Attademo et al, 2016; Awadalla et al, 2019; Barreto et al, 2020; Bhuyan et al, 2020; Burraco and Gomez-Mestre, 2016; Carvalho et al, 2020; Chai et al, 2017; Cheng et al, 2017; Cheron et al, 2022; Costa et al, 2008; Czarniewska et al, 2003; da Silva et al, 2021; David et al, 2012; De Lima Coltro et al, 2017; Dornelles and Oliveira, 2016; Ejilibe et al, 2018; Ezemonye and Tongo, 2010; Falfushynska et al, 2015; Falfushynska et al, 2017; Ferrari et al, 2008; Ferrari et al, 2009; Ferrari et al, 2011; Freitas et al, 2017; Gillardin et al, 2009; Huang et al, 2007; Isnas et al, 2012; Jiang et al, 2019; Jones et al, 2010; Kanter and Celik, 2012; Kostaropoulos et al, 2005; Lajmanovich et al, 2018b; Lajmanovich et al, 2018a; Lajmanovich et al, 2022; Li et al, 2017; Li et al, 2018a; Li et al, 2018b; Liendro et al, 2015; Liu et al, 2006; Liu et al, 2021; Loumbourdis, 2006; Lu et al, 2021; Mardirosian et al, 2015; Marques et al, 2013; Martins et al, 2017; Melvin, 2016; Mussi and Calcaterra, 2010; Naab et al, 2001; Nascimento et al, 2021; Nasia et al, 2018; Özkol et al, 2012; Pal et al, 2018; Papadimitriou and Loumbourdis, 2002; Peltzer et al, 2019; Radovanović et al, 2017; Radovanović et al, 2021; Rosenbaum et al, 2012; Rutkoski et al, 2020; Rutkoski et al, 2021; Saad et al, 2022; Salvaterra et al, 2013; Saria et al, 2014; Shi et al, 2018; Sotomayor et al, 2015; Svartz et al, 2020; Tang et al, 2018; Trachantong et al, 2017;…”

Section: Methodsmentioning

confidence: 99%

The impact of chemical pollution across major life transitions: a meta-analysis on oxidative stress in amphibians

Martin,

Capilla-Lasheras,

Monaghan

et al. 2023

Preprint

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Among human actions threatening biodiversity, the release of anthropogenic chemical pollutants -which have become ubiquitous in the environment- is a major concern. Chemical pollution can induce oxidative stress and damage by causing the overproduction of reactive oxygen species (ROS), and affecting the antioxidant system. In species undergoing metamorphosis (~80% of all extant animal species), antioxidant responses to chemical pollution may differ between pre- and post-metamorphic stages. Here, we meta-analysed (N = 86 studies, k = 2,012 estimates) the impact of chemical pollution on the redox balance across the three major amphibian life stages (embryo, larva, adult). Before metamorphosis, embryos and larvae activate their antioxidant pathways and do not show increased oxidative damage. In contrast, post-metamorphic individuals show unnoticeable antioxidant responses, and a marked oxidative damage in lipids. Also, type of pollutant (i.e., organic vs inorganic) promotes contrasting effects across amphibian life stages. Our findings show a divergent evolution of the redox balance in response to pollutants across life transitions of metamorphosing amphibians, likely linked to the characteristics of each life stage. Further comparative mechanistic approaches to wildlife responses to global changes will improve our understanding of these eco-evo-devo processes.

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The protective role of l-carnitine on oxidative stress, neurotransmitter perturbations, astrogliosis, and apoptosis induced by thiamethoxam in the brains of male rats

Abd Elkader,

Hussein,

Mohammed

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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Synthetic organic insecticides such as pyrethroids, organophosphates, neonicotinoids, and others have the potential to disrupt ecosystems and are often toxic to humans. Thiamethoxam (TMX), a neonicotinoid insecticide , is a widely used insecticide with neurotoxic potential. l-Carnitine (LC) is regarded as the “gatekeeper” in charge of allowing long-chain fatty acids into cell mitochondria. LC is an endogenous chemical that is renowned for its prospective biological activity in addition to its role in energy metabolism. This study investigated the protective effects of LC against TMX-induced neurotoxicity in male Wistar rats. For 28 days, animals were divided into four groups and treated daily with either LC (300 mg/kg), TMX (100 mg/kg), or both at the aforementioned doses. Our results revealed marked serum lipid profile and electrolyte changes, declines in brain antioxidants and neurotransmitters (acetylcholine, dopamine, and serotonin levels) with elevations in thiobarbituric acid reactive substances and proinflammatory cytokine levels, as well as acetylcholinesterase and monoamine oxidase brain activity in TMX-treated rats. TMX also increased the expression of caspase-3 and glial fibrillary acidic protein. In contrast, pretreatment with LC attenuated TMX-induced brain injury by suppressing oxidative stress and proinflammatory cytokines and modulating neurotransmitter levels. It also ameliorated the expression of apoptotic and astrogliosis markers. It could be concluded that LC has antioxidant, anti-inflammatory, anti-astrogliosis, and anti-apoptotic potential against TMX neurotoxicity. Graphical abstract

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Effect of induced sublethal intoxication with neonicotinoid insecticides on Egyptian toads (Sclerophrys regularis)

Cited by 8 publications

References 53 publications

Cytotoxic Effects of the Atrazine Herbicide on Erythrocytes and Liver Damage in Lithobates spectabilis

Cytotoxic Effects of the Atrazine Herbicide on Erythrocytes and Liver Damage in Lithobates spectabilis

The impact of chemical pollution across major life transitions: a meta-analysis on oxidative stress in amphibians

The protective role of l-carnitine on oxidative stress, neurotransmitter perturbations, astrogliosis, and apoptosis induced by thiamethoxam in the brains of male rats

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