2022
DOI: 10.3389/fendo.2022.923448
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Effect of initial levothyroxine dose on neurodevelopmental and growth outcomes in children with congenital hypothyroidism

Abstract: ObjectivesWe designed a multicentre open prospective randomized trial to evaluate the risk-benefit profile of two different initial treatment schemes with levothyroxine (L-T4), 10-12.5 μg/kg/day vs 12.6-15 μg/kg/day, on growth and neurodevelopmental outcomes in children with congenital hypothyroidism (CH) detected by neonatal screening to identify the best range dose to achieve optimal neurocognitive development.Design, patients and methodsChildren detected by neonatal screening were randomly assigned to recei… Show more

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Cited by 10 publications
(9 citation statements)
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“…Herein, the evidence that the surgical correction of varicocele improves the TT levels is seen in many studies and is corroborated by recent meta-analysis published. As we can observe, an increase of around 106 ng/dL could be achieved by the microsurgical technique ( 33 , 34 ).…”
Section: Discussionmentioning
confidence: 79%
See 1 more Smart Citation
“…Herein, the evidence that the surgical correction of varicocele improves the TT levels is seen in many studies and is corroborated by recent meta-analysis published. As we can observe, an increase of around 106 ng/dL could be achieved by the microsurgical technique ( 33 , 34 ).…”
Section: Discussionmentioning
confidence: 79%
“…They showed that the mean difference of TT levels was statistically significant in men before and after varicocelectomy (mean difference = 106.76 ng/dL; p < 0.0001). Although a high heterogeneity was present among the studies ( 34 ).…”
Section: Resultsmentioning
confidence: 99%
“…Immature hypothalamo-pituitary-thyroid axis and thyroid dysfunction are frequently encountered in newborn babies and especially in premature babies (11). Although the relationship between CH and its morbidities in premature babies has been evaluated, the effect of CH on morbidity is still unknown [6][7][8][9][10] . It is known that newborn babies with SGA are at risk for endocrine problems in their advanced ages 26 .…”
Section: Discussionmentioning
confidence: 99%
“…CH is observed more frequently in premature infants than in term infants. In addition to the fact that neurodevelopmental problems are more common in a preterm infant compared to a term infant, the coexistence of prematurity and CH also increases the frequency of adverse clinical outcomes [6][7][8][9][10] .…”
Section: Introductionmentioning
confidence: 99%
“…The similar impact of low (10-12.5 µg/kg/day) and high (12.5-15 µg/kg/day) initial thyroxine dose has been demonstrated in a multicentric randomized control trial, suggesting that the wide dose range of 10-15 µg/kg/day is effective in preventing adverse neurological outcome in congenital hypothyroidism. [7] A study evaluating intellectual outcomes in children with congenital hypothyroidism suggested that the therapeutic window https://ispae-jped.com/…”
mentioning
confidence: 99%