Effect of injectable trace mineral supplementation on peripheral polymorphonuclear leukocyte function, antioxidant enzymes, health, and performance in dairy cows in semi-arid conditions

Silva, Thiago Henrique da; Guimarães, Iuli Caetano da Silva Brandão; Menta, P.R.; Fernandes, Leticia; Paiva, D; Ribeiro, Thiago Lauro Maia; Celestino, M.L.; Netto, Arlindo Saran; Ballou, Michael; Machado, V.S.

doi:10.3168/jds.2021-20624

Cited by 16 publications

(15 citation statements)

References 52 publications

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“…However, it has been reported that exposing fish to Zn oxide nanoparticles increased SOD, CAT, GST and GPx activity [ 46 ]. Other authors found no changes in SOD and GPx after supplementation with Zn, Cu, Se and Mn supplied by subcutaneous injection to dairy cows [ 54 ]. The results of our study show that the hepatic content of Zn, Cu and Mn is positively correlated with GPx activity and negatively correlated with CAT activity.…”

Section: Discussionmentioning

confidence: 99%

Effect of Bis(maltolato)oxovanadium(IV) on Zinc, Copper, and Manganese Homeostasis and DMT1 mRNA Expression in Streptozotocin-Induced Hyperglycemic Rats

Sánchez-González

Moreno

Aranda

et al. 2022

Biology

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Our aim was to examine whether vanadium (IV) corrects alterations in zinc, copper and manganese homeostasis, observed in streptozotocin-induced hyperglycemic rats, and whether such changes are related to divalent metal transporter 1 (DMT1) mRNA expression, and antioxidant and proinflammatory parameters. Four groups of Wistar rats were examined: control; hyperglycemic (H); hyperglycemic treated with 1 mg V/day (HV); and hyperglycemic treated with 3 mg V/day (HVH). Vanadium was supplied in drinking water as bis(maltolato)oxovanadium(IV) for five weeks. Zinc, copper and manganese were measured in food, excreta, serum and tissues. DMT1 mRNA expression was quantified in the liver. Hyperglycemic rats showed increased Zn and Cu absorption and content in the liver, serum, kidneys and femurs; DMT1 expression also increased (p < 0.05 in all cases). HV rats showed no changes compared to H rats other than decreased DMT1 expression (p < 0.05). In the HVH group, decreased absorption and tissular content of studied elements (p < 0.05 in all cases) and DMT1 expression compared to H (p < 0.05) were observed. Liver zinc, copper and manganese content correlated positively with glutathione peroxidase activity and negatively with catalase activity (p < 0.05 in both cases). In conclusion, treatment with 3 mg V/d reverted the alterations in zinc and copper homeostasis caused by hyperglycemia, possibly facilitated by decreased DMT1 expression.

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Section: Discussionmentioning

confidence: 99%

Effect of Bis(maltolato)oxovanadium(IV) on Zinc, Copper, and Manganese Homeostasis and DMT1 mRNA Expression in Streptozotocin-Induced Hyperglycemic Rats

Sánchez-González

Moreno

Aranda

et al. 2022

Biology

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“…This knowledge could be applied to the development of more effective nitrification inhibitors that may reduce N losses from dairy farming systems. Our findings are significant in the context of pastoral systems because dairy farms heavily supplement cows with Cu (López‐Alonso & Miranda, 2020; Silva et al., 2022) or apply farm effluent containing Cu (Panagos et al., 2018). Such Cu inputs can lead to increasing levels of bioavailable Cu in established dairy soils.…”

Section: Discussionmentioning

confidence: 89%

Copper induces nitrification by ammonia‐oxidizing bacteria and archaea in pastoral soils

et al. 2022

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Copper (Cu) is the main co‐factor in the functioning of the ammonia monooxygenase (AMO) enzyme, which is responsible for the first step of ammonia oxidation. We report a greenhouse‐based pot experiment that examines the response of ammonia‐oxidizing bacteria and archaea (AOB and AOA) to different bioavailable Cu concentrations in three pastoral soils (Recent, Pallic, and Pumice soils) planted with ryegrass (Lolium perenne L.). Five treatments were used: control (no urine and Cu), urine only at 300 mg N kg−1 soil (Cu0), urine + 1 mg Cu kg−1 soil (Cu1), urine + 10 mg Cu kg−1 soil (Cu10), and urine + 100 mg Cu kg−1 soil (Cu100). Pots were destructively sampled at Day 0, 1, 7, 15, and 25 after urine application. The AOB/AOA amoA gene abundance was analyzed by real‐time quantitative polymerase chain reaction at Days 1 and 15. The AOB amoA gene abundance increased 10.0‐ and 22.6‐fold in the Recent soil and 2.1‐ and 2.5‐fold in the Pallic soil for the Cu10 compared with Cu0 on Days 1 and 15, respectively. In contrast, the Cu100 was associated with a reduction in AOB amoA gene abundance in the Recent and Pallic soils but not in the Pumice soil. This may be due to the influence of soil cation exchange capacity differences on the bioavailable Cu. Bioavailable Cu in the Recent and Pallic soils influenced nitrification and AOB amoA gene abundance, as evidenced by the strong positive correlation between bioavailable Cu, nitrification, and AOB amoA. However, bioavailable Cu did not influence the nitrification and AOA amoA gene abundance increase.

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“…Five ml of multi-vitamin formulation was injected IM to MV group of cows, which consisted of Vitamin E 5 mg/ml, Vitamin A 1000 IU/ml, B-Complex 5 mg/ml, and Vitamin D 3 500 IU/ml (Zenex Ah HIVIT Plus, multivitamin injection, India). Animals of the MMMV group were injected IM with both (5 ml of multi-minerals and 5 ml of multi-vitamins) consisting of the same formulation (30)(31)(32)(33)35). In all the treatment groups, injections were administered on the 30 th , 15 th , 7 th days before the expected date of parturition, on the day of parturition and on days 7 th , 15 th and 30 th after parturition (Figure 1).…”

Section: Experimental Designmentioning

confidence: 99%

“…Therefore, the alternative use of injectable trace micronutrients is an area of great interest. Injectable/parenteral micronutrient supplementation could potentially be an alternative for supplying more micronutrients during the transition period (27,30,31). Several studies demonstrated that injection of trace mineral solution could increase the concentration of trace minerals such as Cu and Se in liver for at least 2 weeks post injection in bovines (32,33).…”

Section: Immune Cells and Activity 1 Introductionmentioning

confidence: 99%

Repeated injection of multivitamins and multiminerals during the transition period enhances immune response by suppressing inflammation and oxidative stress in cows and their calves

Somagond

Alhussien²,

Dang³

2023

Front. Immunol.

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Periparturient dairy cows undergo major physiological and metabolic changes as well as immunosuppression, associated with decrease in plasma concentrations of various minerals and vitamins. The present study was conducted to investigate effects of repeated injections of vitamins and minerals on oxidative stress, innate and adaptive immune response in periparturient dairy cows and their offspring. Experiment was carried out on 24 peripartum Karan-Fries cows, randomly divided into four groups (n=6): control, Multi-mineral (MM), Multi-vitamin (MV) and Multi-minerals and Multi-vitamin (MMMV). Five ml of MM (Zinc 40 mg/ml, Manganese 10 mg/ml, Copper 15 mg/ml, Selenium 5 mg/ml) and five ml of MV (Vitamin E 5 mg/ml, Vitamin A 1000 IU/ml, B-Complex 5 mg/ml, and Vitamin D3 500 IU/ml) were injected intramuscularly (IM) to the MM and MV groups. MMMV group cows were injected with both. In all treatment groups, injections and blood sampling were carried out on 30th, 15th, 7th days before and after expected date of parturition and at calving. In calves, blood was collected at calving and on 1, 2, 3, 4, 7, 8, 15, 30 and 45 days post-calving. Colostrum/milk were collected at calving and at days 2, 4, and 8 post-calving. A lower percentage of total neutrophils and immature neutrophils, higher percentage of lymphocytes together with increased phagocytic activity of neutrophils and proliferative capacity of lymphocytes found in blood of MMMV cows/calves. Lower relative mRNA expression of TLRs and CXCRs and higher mRNA expression of GR-α, CD62L, CD11b, CD25 and CD44 found in blood neutrophils of MMMV groups. Total antioxidant capacity was higher, activity of antioxidant enzymes (SOD and CAT), TBARS levels were lower in the blood plasma of treated cows/calves. In both cows/calves, plasma pro-inflammatory cytokines (IL-1α, IL-1β, IL-6, IL-8, IL-17A, IFN-γ and TNF-α) increased, whereas anti-inflammatory cytokines (IL-4 and IL-10) decreased in MMMV groups. Total immunoglobulins increased in colostrum/milk of MMMV injected cows and plasma of their calves. Results indicate that repeated injections of multivitamins and multiminerals to peripartum dairy cows could be a major strategy to improve immune response and decrease in inflammation and oxidative stress in transition dairy cows and their calves.

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Effect of injectable trace mineral supplementation on peripheral polymorphonuclear leukocyte function, antioxidant enzymes, health, and performance in dairy cows in semi-arid conditions

Cited by 16 publications

References 52 publications

Effect of Bis(maltolato)oxovanadium(IV) on Zinc, Copper, and Manganese Homeostasis and DMT1 mRNA Expression in Streptozotocin-Induced Hyperglycemic Rats

Effect of Bis(maltolato)oxovanadium(IV) on Zinc, Copper, and Manganese Homeostasis and DMT1 mRNA Expression in Streptozotocin-Induced Hyperglycemic Rats

Copper induces nitrification by ammonia‐oxidizing bacteria and archaea in pastoral soils

Repeated injection of multivitamins and multiminerals during the transition period enhances immune response by suppressing inflammation and oxidative stress in cows and their calves

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