Effect of intensive exercise on plasmatic neutrophil elastase level in eventing and endurance horses

Abstract

Summary Reasons

Specific immuno‐extraction followed by enzymatic detection (SIEFED) of myeloperoxidase and mitochondrial complex I in muscular microbiopsies: preliminary results in endurance horses

“…Our study highlighted that after an endurance race, active MPO is present in horse skeletal muscle and that its activity increases in association with an increase of plasma CK, a witness of muscle damage. These results are to be connected to recent studies which demonstrated that the concentration of 2 inflammatory markers, MPO and elastase, increased both in plasma and muscle in correlation with an increase of the plasmatic CK levels after an endurance race in horses (Lejeune et al . 2010; Serteyn et al .…”

Effect of a 120 km endurance race on plasma and muscular neutrophil elastase and myeloperoxidase concentrations in horses

“…Results of the present study confirm earlier findings of increased post exercise circulating neutrophil numbers and MPO and ELT concentrations in endurance horses (Art et al . 2006; Lejeune et al . 2010).…”

“…Further, increased levels of circulating MPO and ELT have been shown to occur in the post exercise period (Art et al . 2006; Lejeune et al . 2010).…”

“…These studies demonstrated an impairment in the neutrophil function that could persist for several days after intense exercise. Further, increased levels of circulating MPO and ELT have been shown to occur in the post exercise period (Art et al 2006;Lejeune et al 2010). However, little is known on the effect of the inflammatory response on exercise-induced muscle damage.…”

Plasma protein changes in horse after prolonged physical exercise: A proteomic study

“…Augmented levels of the protease inhibitors α1-AT and α1-AT-RP may contribute to suppress elastase activity and indirectly inhibit elastase-related complement activation [72]. This protease increases after intense exercise in horse [43,73] as well as during airway inflammation [74], which often develops during prolonged movement and training [75][76][77]. Moreover, high levels of α1-AT have been found after intensified training in equine muscle biopsy [38].…”