Effect of interleukin-1β gene polymorphisms on clinicopathological features and disease activity of systemic lupus erythematosus

Rashad, Nearmeen M.; Soliman, Mostafa M.; El‐Shal, Amal S.; Said, Dina; Samir, Ghada M.

doi:10.4103/ejim.ejim_92_18

Cited by 5 publications

(2 citation statements)

References 19 publications

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“…LitVar search identified two SNPs that were shared between TLE and all three SADs (i.e., IDDM, SLE, and RA) (Table 1). The first SNP was rs16944 on the Interleukin‐1β (IL‐1β) gene; different studies reported the associations between this gene variation and TLE, 27 RA, 28,29 SLE, 30 and IDDM 31 . The second genetic variation was ε4 variation of apolipoprotein E (APOE) gene that was associated with TLE, 32–34 RA, 35,36 SLE, 37,38 and IDDM 39,40 .…”

Section: Resultsmentioning

confidence: 99%

The genetic link between systemic autoimmune disorders and temporal lobe epilepsy: A bioinformatics study

et al. 2023

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Objective:We aimed to explore the underlying pathomechanisms of the comorbidity between three common systemic autoimmune disorders (SADs) [i.e., insulin-dependent diabetes mellitus (IDDM), systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA)] and temporal lobe epilepsy (TLE), using bioinformatics tools. We hypothesized that there are shared genetic variations among these four conditions. Methods: Different databases (DisGeNET, Harmonizome, and Enrichr) were searched to find TLE-associated genes with variants; their single nucleotide polymorphisms (SNPs) were gathered from the literature. We also did a separate literature search using PubMed with the following keywords for original articles: "TLE" or "Temporal lobe epilepsy" AND "genetic variation," "single nucleotide polymorphism," "SNP," or "genetic polymorphism." In the next step, the SNPs associated with TLE were searched in the LitVar database to find the shared gene variations with RA, SLE, and IDDM.Results: Ninety unique SNPs were identified to be associated with TLE. LitVar search identified two SNPs that were shared between TLE and all three SADs (i.e., IDDM, SLE, and RA). The first SNP was rs16944 on the Interleukin-1β (IL-1β) gene. The second genetic variation was ε4 variation of apolipoprotein E (APOE) gene.Significance: The shared genetic variations (i.e., rs16944 on the IL-1β gene and ε4 variation of the APOE gene) may explain the underlying pathomechanisms of the comorbidity between three common SADs (i.e., IDDM, SLE, and RA) and TLE. Exploring such shared genetic variations may help find targeted therapies for patients with TLE, especially those with drug-resistant seizures who also have comorbid SADs.

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Section: Resultsmentioning

confidence: 99%

The genetic link between systemic autoimmune disorders and temporal lobe epilepsy: A bioinformatics study

et al. 2023

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“…Представляет интерес применение анакинры при РП, развившемся при СКВ, который рецидивировал несмотря на ГК и иммуносупрессивную терапию и успешно контролировался анакинрой (в комбинации с ГК и колхицином) [143]. Примечательно, что при СКВ наблюдается увеличение сывороточной концентрации ИЛ-1β, коррелирующее с актив ностью заболевания [146,147]. В отдельных клинических наблюдениях установлена эффективность лечения анакинрой у пациентов с перикардитом как осложнением гранулематоза с ангиитом и болезни Стилла взрослых.…”

Section: применение анакинры при перикардитеunclassified

Problems of immunopathology and prospects for pharmacotherapy of idiopathic recurrent pericarditis: Using an interleukin 1 inhibitor (Anakinra)

Насонов

Sukmarova²,

Попкова³

et al. 2023

Naučno-praktičeskaâ revmatologiâ

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Pericarditis, a clinical syndrome characterized by inflammation and thickening of the pericardium, is one of the most common forms of inflammatory diseases of the cardiovascular system. The most common and severe complication of acute pericarditis is idiopathic recurrent pericarditis (IRP), which has a poor prognosis associated with the risk of cardiac tamponade and constrictive pericarditis. The pathogenesis of pericarditis is associated with a complex interaction of environmental factors, genetic predisposition, and pathological activation of innate and acquired immunity. Autoinflammatory mechanisms associated with hyperproduction of interleukin (IL) 1 attract particular attention. Standard therapy for pericarditis includes non-steroidal antiinflammatory drugs, colchicine, glucocorticoids, and immunosuppressive drugs. A new direction in the pharmacotherapy of pericarditis is associated with the use of Anakinra (a recombinant non-glycosylated analog of an IL-1 receptor antagonist), which blocks the signaling of IL-1β and IL-1α. The materials of numerous studies are summarized, indicating that Anakinra is an effective drug for the treatment of patients with IRI who are resistant to standard therapy. It is assumed that the wider use of Anakinra, especially in the early stages of pericarditis, will not only improve the prognosis, but also be important for the identification of the autoinflammatory phenotype of IRI and the development of personalized therapy programs.

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Association of genetic variants of interleukin-1β gene -511T/C (rs16944) and +3954C/T (rs1143634) and serum levels of pentaxin (PTX3) and interleukin -1β (IL-1β) with disease activity of systemic lupus erythematosus patients

et al. 2020

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Effect of interleukin-1β gene polymorphisms on clinicopathological features and disease activity of systemic lupus erythematosus

Cited by 5 publications

References 19 publications

The genetic link between systemic autoimmune disorders and temporal lobe epilepsy: A bioinformatics study

The genetic link between systemic autoimmune disorders and temporal lobe epilepsy: A bioinformatics study

Problems of immunopathology and prospects for pharmacotherapy of idiopathic recurrent pericarditis: Using an interleukin 1 inhibitor (Anakinra)

Association of genetic variants of interleukin-1β gene -511T/C (rs16944) and +3954C/T (rs1143634) and serum levels of pentaxin (PTX3) and interleukin -1β (IL-1β) with disease activity of systemic lupus erythematosus patients

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