Effect of Interleukin‐2 and Selenium on the Growth of Squamous Cell Carcinoma Cells

Thikkurissy, Sarath; Pavone, Anthony; Rega, Anthony; Bae, Richard D.; Roy, Marie‐Josée; Wishe, H. I.; Kiremidjian-Schumacher, L.

doi:10.1067/mhn.2001.112878

Cited by 5 publications

(4 citation statements)

References 14 publications

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“…Initially, it was believed that the receptors for lymphokines are expressed only by lymphoid cells (T, B, or NK cells), but recent studies suggest that lymphokine receptors can be found on various malignant cells of nonhematopoietic origin. Human carcinoma lines were shown to express IL‐2R 4, 5, 6. IL‐4R has been found in normal astrocytes, human breast cancer and head and neck carcinoma cells 4, 7, 8, 9.…”

mentioning

confidence: 99%

IL‐12 receptor‐mediated upregulation of FasL in human ovarian carcinoma cells

Gorelik

Edwards

Feng

et al. 2004

Intl Journal of Cancer

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mentioning

confidence: 99%

IL‐12 receptor‐mediated upregulation of FasL in human ovarian carcinoma cells

Gorelik

Edwards

Feng

et al. 2004

Intl Journal of Cancer

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“…Selenium can promote T cells activation by various mechanisms. First, selenium enhances the expression of the alpha (p55) and/or beta (p70/75) subunits of the IL‐2R, facilitates their interaction with IL‐2, and increases T cell activation and proliferation, 34,35 which has been demonstrated in clinical trials. For instance, oral selenium improves immune response through an earlier peak of T cell proliferation 78 .…”

Section: The Role Of Essential Trace Elementsmentioning

confidence: 99%

The roles of essential trace elements in T cell biology

Lan,

Feng,

Liu

et al. 2024

J Cellular Molecular Medi

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T cells are crucial for adaptive immunity to regulate proper immune response and immune homeostasis. T cell development occurs in the thymus and mainly differentiates into CD4+ and CD8+ T cell subsets. Upon stimulation, naive T cells differentiate into distinct CD4+ helper and CD8+ cytotoxic T cells, which mediate immunity homeostasis and defend against pathogens or tumours. Trace elements are minimal yet essential components of human body that cannot be overlooked, and they participate in enzyme activation, DNA synthesis, antioxidant defence, hormone production, etc. Moreover, trace elements are particularly involved in immune regulations. Here, we have summarized the roles of eight essential trace elements (iron, zinc, selenium, copper, iodine, chromium, molybdenum, cobalt) in T cell development, activation and differentiation, and immune response, which provides significant insights into developing novel approaches to modulate immunoregulation and immunotherapy.

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“…This process is accompanied by the rapid production of ROS and increased expression of IL-2, which exert a feedforward and autocrine effect on the proliferation of T cells [145,146]. The function of selenium is related to the capacity of the selenium to enhance the expression of the alpha (p55) and/or beta (p70/75) subunits of the growth regulatory lymphokine interleukin-2 receptor (IL-2R), thereby promoting their interaction with interleukin-2 and ultimately increasing the rate at which cells proliferate and differentiate into cytotoxic cells [147,148]. Selenium can enhance the stimulation of Ca 2+ mobilization in T cells and inhibit the ROS-mediated inhibition of T cell activation [149,150].…”

Section: Adaptive Immunitymentioning

confidence: 99%

Selenium and Selenoproteins in Health

Zhang

Wei

2023

Biomolecules

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Selenium is a trace mineral that is essential for health. After being obtained from food and taken up by the liver, selenium performs various physiological functions in the body in the form of selenoproteins, which are best known for their redox activity and anti-inflammatory properties. Selenium stimulates the activation of immune cells and is important for the activation of the immune system. Selenium is also essential for the maintenance of brain function. Selenium supplements can regulate lipid metabolism, cell apoptosis, and autophagy, and have displayed significant alleviating effects in most cardiovascular diseases. However, the effect of increased selenium intake on the risk of cancer remains unclear. Elevated serum selenium levels are associated with an increased risk of type 2 diabetes, and this relationship is complex and nonlinear. Selenium supplementation seems beneficial to some extent; however, existing studies have not fully explained the influence of selenium on various diseases. Further, more intervention trials are needed to verify the beneficial or harmful effects of selenium supplementation in various diseases.

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Effect of Interleukin‐2 and Selenium on the Growth of Squamous Cell Carcinoma Cells

Abstract: The data suggested that local immunotherapy with IL-2 in hosts supplemented with Se may represent an effective modality of treatment for the prevention of recurrences at the site of conventionally treated primary tumors, including tumors that do not express IL-2 receptors.

Cited by 5 publications

References 14 publications

IL‐12 receptor‐mediated upregulation of FasL in human ovarian carcinoma cells

IL‐12 receptor‐mediated upregulation of FasL in human ovarian carcinoma cells

The roles of essential trace elements in T cell biology

Selenium and Selenoproteins in Health

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