Effect of interleukin-4 on orthodontic tooth movement and associated root resorption

Hakami, Zaki; Kitaura, Hideki; Kimura, Keisuke; Ishida, Masahiko; Sugisawa, Haruki; Ida, Hiroto; Saeed, Jafari; Takano‐Yamamoto, Teruko

doi:10.1093/ejo/cju016

Cited by 32 publications

(50 citation statements)

References 42 publications

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“…Therefore, we evaluated the effect of the vibration device on root resorption. Consistent with previous findings 4 , 49 , experimental tooth movement under a continuous static force of 15 gf induced root resorption in rats. Dynamic vibration applied with continuous static force also induced a certain degree of root resorption compared with the control group; however, the increase was not significant.…”

Section: Discussionsupporting

confidence: 93%

“…It has been reported that some degree of root resorption occurs in almost all patients during orthodontic treatment, ranging from minor to severe 46 – 48 . In animal models, it was demonstrated that experimental tooth movement by means of both light and heavy forces induced root resorption in mice 4 and rats 49 . Therefore, we evaluated the effect of the vibration device on root resorption.…”

Section: Discussionmentioning

confidence: 99%

“…7a ). As described previously 49 , from the obtained images, the root area and area of root resorption lacunae in the 3 roots were measured using software (Image J; National Institutes of Health (NIH)). The root resorption rate for each root (area of root resorption lacunae/root area × 100) was calculated using software (Excel; Microsoft Co., WA, USA).…”

Section: Methodsmentioning

confidence: 99%

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Synergistic acceleration of experimental tooth movement by supplementary high-frequency vibration applied with a static force in rats

Takano‐Yamamoto

Sasaki

Fatemeh

et al. 2017

Sci Rep

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Several recent prospective clinical trials have investigated the effect of supplementary vibration applied with fixed appliances in an attempt to accelerate tooth movement and shorten the duration of orthodontic treatment. Among them, some studies reported an increase in the rate of tooth movement, but others did not. This technique is still controversial, and the underlying cellular and molecular mechanisms remain unclear. In the present study, we developed a new vibration device for a tooth movement model in rats, and investigated the efficacy and safety of the device when used with fixed appliances. The most effective level of supplementary vibration to accelerate tooth movement stimulated by a continuous static force was 3 gf at 70 Hz for 3 minutes once a week. Furthermore, at this optimum-magnitude, high-frequency vibration could synergistically enhance osteoclastogenesis and osteoclast function via NF-κB activation, leading to alveolar bone resorption and finally, accelerated tooth movement, but only when a static force was continuously applied to the teeth. These findings contribute to a better understanding of the mechanism by which optimum-magnitude high-frequency vibration accelerates tooth movement, and may lead to novel approaches for the safe and effective treatment of malocclusion.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Synergistic acceleration of experimental tooth movement by supplementary high-frequency vibration applied with a static force in rats

Takano‐Yamamoto

Sasaki

Fatemeh

et al. 2017

Sci Rep

Self Cite

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“…Sequential 5-µm serial sections were prepared from each paraffin block and the five sections containing the largest root area were chosen and analyzed histomorphometrically, as described previously. 24 , 25 The final value was expressed as the mean of the selected sections. 26 The mesial root was histomorphometrically evaluated on the section containing the full length of the root from the cemento-enamel junction (CEJ) to the apex, by means of a double-headed Olympus BX-41 light microscope equipped with a digital camera (DP25 Olympus) and analysis software (DP2-BSW, Olympus).…”

Section: Methodsmentioning

confidence: 99%

Effect of supplementary zinc on orthodontic tooth movement in a rat model

Akhoundi

Ghazanfari

Etemad‐Moghadam

et al. 2016

Dental Press J. Orthod.

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Introduction: Osteoclasts and osteoblasts are responsible for regulating bone homeostasis during which the trace element zinc has been shown to exert a cumulative effect on bone mass by stimulating osteoblastic bone formation and inhibiting osteoclastic bone resorption. Objective: The aim of the present study was to investigate the effects of zinc (Zn) on orthodontic tooth movement (OTM) in a rat model. Material and Methods: A total of 44 male Wistar rats were divided into four groups of 11 animals each and received 0, 1.5, 20 and 50 ppm Zn in distilled water for 60 days. In the last 21 days of the study, nickel-titanium closed coil springs were ligated between maxillary right incisors and first molars of all rats, and tooth movement was measured at the end of this period. Histological analysis of hematoxylin/eosin slides was performed to assess root resorption lacunae, osteoclast number and periodontal ligament (PDL) width. Results: Mean OTM was calculated as 51.8, 49.1, 35.5 and 45 µm in the 0, 1.5, 20 and 50 ppm zinc-receiving groups, respectively. There were no significant differences in neither OTM nor histological parameters among the study groups (p > 0.05). Conclusion: According to the results obtained in the current investigation, increase in supplementary zinc up to 50 ppm does not affect the rate of OTM neither bone and root resorption in rats.

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“…Of the 13 studies, all were regarded as non-randomized. The most frequently used animals were rats (11 studies), whereas in two studies mice were used for the experiments (Yoshimatsu et al, 2012 ; Hakami et al, 2015 ). The sample sizes ranged from 24 (Seifi et al, 2003 ) to 132 (Boekenoogen et al, 1996 ) (min-max).…”

Section: Resultsmentioning

confidence: 99%

Intrinsic Hormone-Like Molecules and External Root Resorption During Orthodontic Tooth Movement. A Systematic Review and Meta-Analysis in Preclinical in-Vivo Research

2018

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Background: External root resorption constitutes an adverse effect of orthodontic treatment. The aim of the present meta-analysis was to identify the effect of induced intrinsic/ hormone-like molecules such as prostaglandins, interleukins and others on external root resorption after orthodontic tooth movement in experimental animalsMethods: An electronic database search of the literature was performed (Medline via PubMed, EMBASE, LILACS, and Open Gray). Search terms included root resorption, tooth movement and animal type. Risk of bias assessment was made using the SYRCLE guidelines for animal studies and reporting quality was assessed through ARRIVE. Random effects meta-analysis was performed for the outcome root resorption after orthodontic tooth movement.Results: Of the 124 articles initially retrieved, 13 were eligible for inclusion in the systematic review, while only 2 were included in the quantitative synthesis. Five studies investigated the effect of Prostaglandin E2, four studies the effect of Thyroxine, two the effect of Calcium ions (Ca++), while the rest investigated Misoprostol, Interleukin-12 and Interleukin-4. Risk of Bias in all studies was judged to be high overall, while reporting quality was suboptimal. According to the quantitative synthesis, there was no difference in root resorption after orthodontic tooth movement when Prostaglandin E2 coupled with Ca++ was administered in comparison to no substance administration (SMD: 0.48 mm2; 95% CI: −0.22, 1.19; p = 0.18).Conclusions: Overall, there was no evidence to suggest a variation in root resorption when Prostaglandin E2 and Ca++ were administered, while there is an overriding need for further high quality experimental studies to inform available evidence on the effect of intrinsic substances on external root resorption.

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Effect of interleukin-4 on orthodontic tooth movement and associated root resorption

Abstract: IL-4 inhibits tooth movement and prevents root resorption in the mouse model. These results suggest that IL-4 could be used as a useful adjunct to regulate the extent of OTM and also to control root resorption.

Cited by 32 publications

References 42 publications

Synergistic acceleration of experimental tooth movement by supplementary high-frequency vibration applied with a static force in rats

Synergistic acceleration of experimental tooth movement by supplementary high-frequency vibration applied with a static force in rats

Effect of supplementary zinc on orthodontic tooth movement in a rat model

Intrinsic Hormone-Like Molecules and External Root Resorption During Orthodontic Tooth Movement. A Systematic Review and Meta-Analysis in Preclinical in-Vivo Research

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