Effect of Intraperitoneal Curcumin Instillation on Postoperative Peritoneal Adhesions

Abstract

Objective: The aim of this study was to determine the effect of curcumin on adhesion formation in a rat cecum abrasion model. Materials and Methods: Thirty Wistar rats were randomized into three groups; the control group received saline, the curcumin group received 10 mg/kg of curcumin after cecal abrasion, and in the sham group the abdominal wall was closed without any abrasion to the cecum. On day 15, adhesions were assessed blindly using a standardized scale, and histopathological samples were taken and examined. Results: There were no incisional hernias or wound dehiscences in any animals of the three groups. A comparison of adhesion scores showed a significant difference between the curcumin (median = 1) and the control group (median = 2; p < 0.05). The grade of inflammation of the curcumin (median = 1) and the sham (median = 0) group was significantly lower than that of the control group (median = 3; p < 0.01 and p < 0.001, respectively). Hydroxyproline levels were significantly lower in the sham (48.3 ± 11.8 µg/mg) and the curcumin (63.8 ± 13.9 µg/mg) group compared to the control group (85.7 ± 22.1 µg/mg; p < 0.05). Conclusion: These data suggest that curcumin, administered intraperitoneally, was effective in the prevention of peritoneal adhesion formation.

Cordycepin prevents postoperative formation of intra-abdominal adhesions in a rat model: An experimental study

“…[1,2] Recently, new surgical techniques, mucosal barriers, and many therapeutic agents, including progesterone, curcumin, methylene blue, vitamin E, surfactants, and hyperbaric oxygen, have been developed in efforts to prevent adhesion, but the work continues. [1,[3][4][5][6] Cordycepin, an adenosine analogue initially isolated in China in 1964, has been demonstrated to have a variety of biological functions, and is used to treat various medical conditions. Cordycepin has fibrinolytic, anti-apoptotic, antioxidant, anti-inflammatory, antimicrobial, immunomodulatory, nephroprotective, and hepatoprotective effects.…”

Application of Traditional Chinese Medicines in Postoperative Abdominal Adhesion

“…Futhermore, curcumin has also been shown to increase fibrinolytic activity and cell migration towards the wound area, which makes it possible to be safe and effective in the prevention of PAA [56]. It has shown that treatment with 10 mg/kg curcumin for 15 days can significantly prevent PAA [57]. However, further studies are needed to show the most suitable and effective dose of curcumin for PAA in clinics.…”

Surface Engineered Peroxidase-Mimicking Gold Nanoparticles to Subside Cell Inflammation

“…Recently, Au nanoparticles were synthesized employing curcumin (diferuloylmethane) as a reducing and stabilizing agent, which is a naturally occurring hydrophobic compound of the ginger family Zingiberaceae . − Curcumin has multiple medical benefits including antioxidant, antiviral, antitumor, and skin and/or wound healing properties. It increases fibrinolytic and cell-migration response near the wound area thus upregulating the healing mechanism . Moreover, preclinical trials on animal models have revealed the chemopreventive, antineoplastic, and anti-inflammatory properties of curcumin .…”

“…It increases fibrinolytic and cell-migration response near the wound area thus upregulating the healing mechanism. 17 Moreover, preclinical trials on animal models have revealed the chemopreventive, antineoplastic, and anti-inflammatory properties of curcumin. 18 However, its use is limited because of poor absorption, low solubility (at physiological pH), and rapid metabolism.…”