Effect of isolated vitamin D supplementation on bone turnover markers in younger postmenopausal women: a randomized, double-blind, placebo-controlled trial

Nahás-Neto, Jorge; Cangussu, Luciana Mendes; Orsatti, Cláudio Lera; Bueloni-Dias, Flávia Neves; Poloni, Priscila Ferreira; Schmitt, Eneida Boteon; Nahás, Eliana Aguiar Petri

doi:10.1007/s00198-018-4395-y

Cited by 34 publications

(39 citation statements)

References 40 publications

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“…However, the relationship between vitamin D concentration and bone resorption or formation biomarkers is still inconclusive because of different study group ages, ethnicities, or countries in various latitudes. A randomized, double-blind, placebo-controlled trial in postmenopausal women showed that supplementation with 1000 IU of vitamin D 3 daily can significantly increase both serum CTX and P1NP levels, which means administration of vitamin D can restore the decrease in bone resorption and formation [103]. Additionally, the PTH level significantly decreases together with an elevated vitamin D level after vitamin D is given [103].…”

Section: The Association Of Uric Acid and Bone Health In Epidemiolmentioning

confidence: 99%

The Paradoxical Role of Uric Acid in Osteoporosis

Lin

Hung

et al. 2019

Nutrients

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Because of its high prevalence worldwide, osteoporosis is considered a serious public health concern. Many known risk factors for developing osteoporosis have been identified and are crucial if planning health care needs. Recently, an association between uric acid (UA) and bone fractures had been explored. Extracellular UA exhibits antioxidant properties by effectively scavenging free radicals in human plasma, but this benefit might be disturbed by the hydrophobic lipid layer of the cell membrane. In contrast, intracellular free oxygen radicals are produced during UA degradation, and superoxide is further enhanced by interacting with NADPH oxidase. This intracellular oxidative stress, together with inflammatory cytokines induced by UA, stimulates osteoclast bone resorption and inhibits osteoblast bone formation. UA also inhibits vitamin D production and thereby results in hyper-parathyroidism, which causes less UA excretion in the intestines and renal proximal tubules by inhibiting the urate transporter ATP-binding cassette subfamily G member 2 (ABCG2). At normal or high levels, UA is associated with a reduction in bone mineral density and protects against bone fracture. However, in hyperuricemia or gout arthritis, UA increases bone fracture risk because oxidative stress and inflammatory cytokines can increase bone resorption and decrease bone formation. Vitamin D deficiency, and consequent secondary hyperparathyroidism, can further increase bone resorption and aggravated bone loss in UA-induced osteoporosis.

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Section: The Association Of Uric Acid and Bone Health In Epidemiolmentioning

confidence: 99%

The Paradoxical Role of Uric Acid in Osteoporosis

Lin

Hung

et al. 2019

Nutrients

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“…Observational studies report increased bone resorption with vitamin D deficiency [35, 36]. Despite observations of increased bone turnover, RCT’s assessing the effect of vitamin D supplementation on markers of bone turnover have shown inconsistent results [25, 26, 37–39].…”

Section: Discussionmentioning

confidence: 99%

Effect of vitamin D fortified foods on bone markers and muscle strength in women of Pakistani and Danish origin living in Denmark: a randomised controlled trial

Grønborg

Tetens

Andersen

et al. 2019

Nutr J

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BackgroundDeficient and insufficient vitamin D status (defined as serum 25(OH)D < 30 nmol/L and > 50 nmol/L) is prevalent worldwide and associated with decreased muscle strength and poor bone health. We aimed to investigate the effect of vitamin D fortification on bone markers and muscle strength among younger adult women at risk of vitamin D deficiency.MethodsA 12-week randomised double-blinded placebo-controlled winter intervention trial, providing 30 μg vitamin D3/day through fortified yoghurt, cheese, eggs and crisp-bread or similar placebo products. Participants were 143 women of Danish and Pakistani origin 18–50 years of age, living in Denmark, randomised into four groups stratified by ethnicity. Serum 25-hydroxyvitamin D (25(OH)D) by LC-MS/MS and the secondary endpoints: four specific bone markers (osteocalcin (OC), Bone specific Alkaline Phosphatase (BALP), Procollagen type 1 amino-terminal propeptide (P1NP), C-terminal crosslinked telopeptide of type 1 collagen (CTX)) and three muscle strength measures (handgrip, knee extension strength, chair-standing), were assessed using one-way ANOVA, Tukey HSD and subsequent linear ANCOVA models, adjusted for relevant covariates.ResultsSignificantly increased serum 25(OH)D concentration from 53.3 (17) to 77.8 (14) nmol/L and from 44.5 (21) to 54.7 (18) nmol/L among Danish and Pakistani women in the fortified groups, respectively (P < 0.05). The bone turnover markers OC, BALP, P1NP and CTX did not change significantly. Muscle strength by handgrip, knee extension and chair-standing test did not change significantly following the intervention.ConclusionsConsumption of vitamin D fortified foods for 12 weeks did not result in significant changes of the bone turnover markers OC, BALP, P1NP and CTX. Muscle strength measured as hand grip strength, knee extension strength and chair-standing did not change significantly following the intervention.

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“…However, in subjects whose 25(OH)D concentration exceeded 30 ng/ml, an increase of CTX levels was observed [21]. Conversely, it has been demonstrated that improved vitamin D status in younger postmenopausal women leads to a signi cant reduction in serum CTX and PINP levels [22]. The ndings of the current study are in agreement with the latter study, in that we observed that in both EG and PAM groups, concentration of 25(OH)D below the median value of 22.50 ng/ml was associated with higher CTX levels at baseline.…”

Section: Response To Want and Vitamin Dmentioning

confidence: 99%

Serum levels of bone formation and resorption markers in relation to vitamin D status in professional gymnastics and physically active men during upper and lower body high-intensity exercise

Mieszkowski

Kochanowicz

Piskorska

et al. 2021

Preprint

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Purpose/Introduction: To compare serum levels of bone turnover markers in athletes and non-athletes, and to evaluate the relationship between serum levels of vitamin D metabolites and exercise-induced changes in biomarker levels. Methods: Sixteen elite male artistic gymnasts (EG; 21.4 ± 0.8 years-old) and 16 physically active men (the control group, PAM; 20.9 ± 1.2 years-old) performed lower and upper body 30-s Wingate anaerobic tests (LBWT and UBWT, respectively). For biomarker analysis, blood samples were collected before, and 5 and 30 min after exercise. Samples for vitamin D levels were collected before exercise. N-terminal propeptide of type I collagen (PINP) was analysed as a marker of bone formation. C-terminal telopeptide of type I collagen (CTX) was analysed as a marker of bone resorption.Results: UBWT fitness readings were better in the EG group than in the PAM group, with no difference in LBWT readings between the groups. UBWT mean power was 8.8% higher in subjects with 25(OH)D3 levels over 22.50 ng/ml and in those with 24,25(OH)2D3 levels over 1.27 ng/ml. Serum CTX levels increased after both tests in the PAM group, with no change in the EG group. PINP levels did not change in either group; however, in PAM subjects with 25(OH)D3 levels above the median, they were higher than those in EG subjects. Conclusion: Vitamin D metabolites affect the anaerobic performance and bone turnover markers at rest and after exercise. Further, adaptation to physical activity modulates the effect of anaerobic exercise on bone metabolism markers.

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Effect of isolated vitamin D supplementation on bone turnover markers in younger postmenopausal women: a randomized, double-blind, placebo-controlled trial

Abstract: In younger postmenopausal women with VD deficiency, isolated supplementation with 1000 IU of vitamin D3 for 9 months is associated with a reduction in bone turnover markers. However, any between-group differences was not observed in bone turnover markers.

Cited by 34 publications

References 40 publications

The Paradoxical Role of Uric Acid in Osteoporosis

The Paradoxical Role of Uric Acid in Osteoporosis

Effect of vitamin D fortified foods on bone markers and muscle strength in women of Pakistani and Danish origin living in Denmark: a randomised controlled trial

Serum levels of bone formation and resorption markers in relation to vitamin D status in professional gymnastics and physically active men during upper and lower body high-intensity exercise

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