Effect of ketoprofen on pre-weaning piglet mortality on commercial farms

Homedes, Josep; Salichs, Marta; Sabaté, David; Sust, Mariano; Fabre, R.

doi:10.1016/j.tvjl.2014.05.038

Cited by 19 publications

(27 citation statements)

References 5 publications

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“…NSAIDs are weak organic acids that cannot pass freely through the phospholipid bilayer and that inhibit cyclooxygenase enzymes (COX I and II) from converting arachidonic acid into pro-inflammatory prostaglandins [117]. Homedes et al [118] found the NSAID ketaprofen improved piglet survival at days two to seven postpartum and that this effect was most pronounced in large litters. Other studies involving both ketaprofen and meloxican found no evidence of improved piglet survival [119][120][121][122].…”

Section: Non-steroidal Anti-inflammatory Drugs (Nsaids)mentioning

confidence: 99%

“…Other studies involving both ketaprofen and meloxican found no evidence of improved piglet survival [119][120][121][122]. As colostrum and milk production are limiting factors in larger litters, it has been suggested the benefits of ketaprofen were influenced by the sow's improved milk production [118]. NSAIDs have been found to significantly reduce the incidence of constipation in sows [121], which is important for milk yield due to reduced levels of lipopolysaccharide absorption and increased levels of circulating prolactin [121].…”

Section: Non-steroidal Anti-inflammatory Drugs (Nsaids)mentioning

confidence: 99%

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Are Larger Litters a Concern for Piglet Survival or An Effectively Manageable Trait?

Ward

Kirkwood

Plush³

2020

Animals

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As sows continue to be selected for greater prolificacy, it is important to review problems that arise in larger litters, and whether these issues can be appropriately managed. Although a proportion of piglets in larger litters can be born underweight, proper supervision around farrowing and adequate colostrum intake has the potential to improve the survival of low-birth-weight piglets and their ongoing growth to weaning. As larger litters can impart greater stress and discomfort on sows, implementing a low-stress environment leading up to parturition may improve sow performance and subsequent survival of piglets. Additionally, treating sows with anti-inflammatory compounds, either dietary or pharmacologically, shows some promise for alleviating sow discomfort and improving piglet survival in larger litters. Understanding that selecting sows for larger litters not only affects piglet survival but the well-being of the sow, the decision to continue selecting for larger litters, regardless of management strategies, remains a topic of ethical concern.

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Section: Non-steroidal Anti-inflammatory Drugs (Nsaids)mentioning

confidence: 99%

Section: Non-steroidal Anti-inflammatory Drugs (Nsaids)mentioning

confidence: 99%

Are Larger Litters a Concern for Piglet Survival or An Effectively Manageable Trait?

Ward

Kirkwood

Plush³

2020

Animals

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“…It has been suggested that pain experienced by the sow post-farrowing, could affect her ability to feed and care for piglets ( 3 , 4 ), which is a welfare concern for the sow and piglets and also an economic one for the farmer. This has resulted in recent research administering non-steroidal anti-inflammatory drugs (NSAIDs) post-farrowing and measuring the benefits to health, welfare and productivity ( 6 – 11 ).…”

Section: Introductionmentioning

confidence: 99%

“…Benefits of the post-farrowing administration of NSAIDs include a reduction in piglet mortality with the use of ketoprofen ( 6 , 8 ), and an increased average daily weight gain of low birth weight piglets (< 1180 g) with the use of intramuscular meloxicam ( 7 ). A study in which oral meloxicam was administered as soon as possible after the onset of farrowing showed improved piglet weaning weight, average daily gain and evidence for improved immunoglobulin-G (IgG) transfer ( 12 ).…”

Section: Introductionmentioning

confidence: 99%

“…Scientific research has demonstrated the efficacy of ketoprofen in experimentally infected pigs ( 19 , 20 ), to treat respiratory disease ( 21 ), and non-infectious lameness ( 22 ). As previously mentioned, the post-farrowing administration of ketoprofen has shown health, welfare, and production benefits ( 6 , 10 , 11 ), especially on farms with a high incidence of PPDS ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

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Periparturient Behavior and Physiology: Further Insight Into the Farrowing Process for Primiparous and Multiparous Sows

Ison

Jarvis

et al. 2018

Front. Vet. Sci.

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Giving birth is a critical time for many species and is often the most painful event ever experienced by females. In domestic species, like the pig, pain associated with parturition represents a potential welfare concern, and the consequences of pain can cause economic losses (e.g., by indirectly contributing to piglet mortality as pain could slow post-farrowing recovery, reduce food and water intake, reducing milk let-down). This study investigated pain assessment and its management in primiparous (gilts) and multiparous (sows) breeding pigs, including the provision of a non-steroidal anti-inflammatory drug (NSAID) post-parturition. Individuals were randomly allocated to receive the NSAID ketoprofen (3 mg/kg bodyweight) (n = 11 gilts, 16 sows) or the equivalent volume of saline (n = 13 gilts, 16 sows) by intramuscular injection 1.5 h after the birth of the last piglet. Data collected included putative behavioral indicators of pain (back leg forward, tremble, back arch), salivary cortisol concentrations pre-farrowing and up to 7 days post-injection. In addition, post-partum biomarkers of inflammation, including the acute phase protein C-reactive protein (CRP) and 3 porcine cytokines [interleukin-1 β (IL1 β), interleukin-6 (IL6), and tumor necrosis factor α (TNF α)] were measured in plasma collected 6 h following the injection. Behaviors were analyzed using generalized linear mixed models, and physiological variables with linear mixed models. No difference in putative pain behaviors, salivary cortisol, CRP, or cytokines were found between individuals treated with ketoprofen or those administered the saline control. However, there were some differences between gilts and sows, as sows exhibited more putative pain behavior than gilts, had higher salivary cortisol on the day of farrowing and had higher plasma TNF α. Conversely, gilts had higher salivary cortisol than sows on day 3 post-farrowing and had higher CRP. This indicates that, like human females, multiparous sows experience more pain from uterine activity following birth than primiparas. This study provides useful information for developing management practices relating to post-farrowing care for breeding pigs.

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Reproductive health of the sow during puerperium

Björkman

Kauffold

Kaiser

2022

Molecular Reproduction Devel

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The modern hyperprolific sow is susceptible to metabolic disease and chronic inflammation. The most sensitive phase is parturition, when the sow experiences systemic inflammation and stress, and major changes in metabolism and endocrinology. Resolution of inflammation and stress needs to happen quickly to ensure good reproductive health during puerperium. If the sow fails to adapt to these changes, puerperal disease may occur. The economically most important puerperal disease complex is the postpartum dysgalactia syndrome (PPDS). Other puerperal diseases include infections of the urogenital tract. Diagnosis of PPDS and urogenital disease on‐farm is challenging but several diagnostic methods, including clinical examination, behavioral observations, ultrasonography and biomarkers are available. Ultrasonography is an excellent tool for monitoring the health of the urogenital tract, the mammary gland, and uterine involution and guide further diagnostic interventions. Biomarkers such as Chromogranin A, tumor necrosis factor‐α, and interleukin‐6 represent promising tools to monitor general health and the systemic state of inflammation and oxidative stress of the sow. Nonsteroidal anti‐inflammatory drugs, dopamine antagonists, and oxytocin are promising to address the symptoms of PPDS. Reducing of stress, improving nutrition and intestinal health, and supporting animal welfare‐friendly husbandry help in the prevention of PPDS.

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Effect of ketoprofen on pre-weaning piglet mortality on commercial farms

Cited by 19 publications

References 5 publications

Are Larger Litters a Concern for Piglet Survival or An Effectively Manageable Trait?

Are Larger Litters a Concern for Piglet Survival or An Effectively Manageable Trait?

Periparturient Behavior and Physiology: Further Insight Into the Farrowing Process for Primiparous and Multiparous Sows

Reproductive health of the sow during puerperium

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