1978
DOI: 10.1161/01.res.43.1.24
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Effect of l-dopa on sympathetic nerve activity and blood pressure in the spontaneously hypertensive rat.

Abstract: SUMMARY We examined the effect of L-dopa, after peripheral L-amino acid decarboxylase inhibition, on sympathetic nerve activity (SNA) and blood pressure in spontaneously hypertensive rats (SHR) and in normotensive control rats. L-Dopa reduced SNA in both groups of animals. The SHRs were significantly more sensitive to the depressor effect of L-dopa than were the control animals, the threshold dose for reduction of SNA being 3 mg/kg in SHR and 15 mg/kg in control rats. Similarly, the magnitude of inhibition of … Show more

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Cited by 53 publications
(21 citation statements)
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“…(Hypertension 1: 598-604, 1979) KEY WORDS • spontaneous hypertension • sympathetic nervous system • backcross rat • genetics • blood pressure E XCESSIVE activity of the sympathetic nervous system has been shown to be a significant causative factor in the hypertension of the Okamoto strain of the spontaneously hypertensive rat (SHR). Directly measured sympathetic nerve activity (SNA) is markedly increased in the SHR compared to normotensive Wistar rats, 15 and surgical or pharmacological abolition of SNA leads to greater reductions in blood pressure in the SHR. 611 The mechanisms responsible for the increased SNA, which results in hypertension in the SHR, are unknown.…”
mentioning
confidence: 99%
See 1 more Smart Citation
“…(Hypertension 1: 598-604, 1979) KEY WORDS • spontaneous hypertension • sympathetic nervous system • backcross rat • genetics • blood pressure E XCESSIVE activity of the sympathetic nervous system has been shown to be a significant causative factor in the hypertension of the Okamoto strain of the spontaneously hypertensive rat (SHR). Directly measured sympathetic nerve activity (SNA) is markedly increased in the SHR compared to normotensive Wistar rats, 15 and surgical or pharmacological abolition of SNA leads to greater reductions in blood pressure in the SHR. 611 The mechanisms responsible for the increased SNA, which results in hypertension in the SHR, are unknown.…”
mentioning
confidence: 99%
“…Directly measured sympathetic nerve activity (SNA) is markedly increased in the SHR compared to normotensive Wistar rats, 15 and surgical or pharmacological abolition of SNA leads to greater reductions in blood pressure in the SHR. 611 The mechanisms responsible for the increased SNA, which results in hypertension in the SHR, are unknown.…”
mentioning
confidence: 99%
“…These patients might then have initiated secondary mechanisms that would continue the hypertension and be analogous to the experimental counterpart of metacorticoid hypertension (33). There is also some evidence that a dopaminergic mechanism unrelated to aldosterone secretion may be etiologic in the hypertension of the spontaneous hypertensive rat, since both bromocriptine and L-dopa administration reverse the hypertension in this model, whereas they cause no significant fall in blood pressure in normal controls (34,35). Further studies would be helpful in clarifying the relationship between adrenal, renal, and systemic dopaminergic mechanisms, all of which might influence blood pressure regulation.…”
Section: Methodsmentioning
confidence: 91%
“…For example, intravenous administration of DOPA after blockade of extracerebral AADC by carbidopa produces decreases in plasma renin activity and blood pressure (29). DOPA reduces sympathetic nerve activity and blood pressure in spontaneously hypertensive rats after peripheral AADC inhibition (24). It might be possible that these effects are caused by the actions of DOPA itself in peripheral tissues.…”
Section: The Effects Of Dopa On Cardiovascular Functionsmentioning
confidence: 99%
“…Although a large amount of work suggests that DOPA is largely inert, there are some reports showing that the cardiovascular effects of DOPA are seen under the treatment of peripheral AADC inhibitors (23,24,29). For example, intravenous administration of DOPA after blockade of extracerebral AADC by carbidopa produces decreases in plasma renin activity and blood pressure (29).…”
Section: The Effects Of Dopa On Cardiovascular Functionsmentioning
confidence: 99%