Effect of layered double hydroxide intercalated with fluoride ions on the physical, biological and release properties of a dental composite resin

Tammaro, Loredana; Vittoria, Vittoria; Calarco, Anna; Petillo, Orsolina; Riccitiello, Francesco; Peluso, Gianfranco

doi:10.1016/j.jdent.2013.10.019

Cited by 41 publications

(54 citation statements)

References 32 publications

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“…Besides to the delivery of marketed drugs Tammaro et al (2014), have intercalated fluoride ion successfully for its controlled delivery using LDH precursor incorporated in a dental resin consisting of bisphenol-A glycidyl dimethacrylate (Bis-GMA), camphorquinone (CQ), tri-ethylene glycol dimethacrylate (TEGDMA), ethoxylated bisphenol-A dimethacrylate (EBPADMA) and glass fillers to promote human dental pulp stem cells proliferation and differentiation that can be used as a promising filler for dental resin.…”

Section: Controlled and Sustained Drug Release Propertiesmentioning

confidence: 99%

Layered double hydroxide nanoparticles for biomedical applications: Current status and recent prospects

Kuthati

Kankala

Lee

2015

Applied Clay Science

225

123

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Section: Controlled and Sustained Drug Release Propertiesmentioning

confidence: 99%

Layered double hydroxide nanoparticles for biomedical applications: Current status and recent prospects

Kuthati

Kankala

Lee

2015

Applied Clay Science

225

123

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“…Fluoroapatites, phosphate minerals formed by fluoride binding to calcium HA used as fillers able to conduct enamel mineralization and interfere with bacterial metabolism and dental plaque acidogenicity [47]: such materials can also remineralize dentin and help prevent secondary caries [48,49].…”

Section: Restorative Approaches To Pathological Alterationsmentioning

confidence: 99%

Biodegradable polymers for dental tissue engineering and regeneration

Conte¹,

Riccitiello²,

Luise³

et al. 2017

Biodegradable Polymers: Recent Developments and New Perspectives

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“…The hDPSCs were enzymatically isolated from impacted third molars from 10 adults (18-22 years of age) as previously described (Gronthos et al 2000;Tammaro et al 2014). The teeth were obtained in compliance with Italian legislation (including informed consent and institutional review board approval of the protocol number 7413).…”

Section: Cell Isolation and Magnetic-activated Cell Sortingmentioning

confidence: 99%

Long-Term Fluoride Release from Dental Resins Affects STRO-1⁺ Cell Behavior

et al. 2015

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Fluoride-releasing restorative dental materials can be beneficial to remineralize dentin and help prevent secondary caries. However, the effects of fluoride release from dental materials on the activity of dental pulp stem cells are not known. Here we investigate whether different fluoride release kinetics from dental resins supplemented with modified hydrotalcite (RK-F10) or fluoride-glass filler (RK-FG10) could influence the behavior of a human dental pulp stem cell subpopulation (STRO-1(+) cells) known for its ability to differentiate toward an odontoblast-like phenotype. The 2 resins, characterized by similar physicochemical properties and fluoride content, exhibited different long-term fluoride release kinetics. Our data demonstrate that long-term exposure of STRO-1(+) cells to a continuous release of a low amount of fluoride by RK-F10 increases their migratory response to transforming growth factor β1 (TGF-β1) and stromal cell-derived factor 1 (SDF-1), both important promoters of pulp stem cell recruitment. Moreover, the expression patterns of dentin sialoprotein (dspp), dentin matrix protein 1 (dmp1), osteocalcin (ocn), and matrix extracellular phosphoglycoprotein (mepe) indicate a complete odontoblast-like cell differentiation only when STRO-1(+) cells were cultured on RK-F10. On the contrary, RK-FG10, characterized by an initial fluoride release burst and reduced lifetime of the delivery, did not elicit any significant effect on both STRO-1(+) cell migration and differentiation. Taken together, our results highlight the importance of taking into account fluoride release kinetics in addition to fluoride concentration when designing new fluoride-restorative materials.

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Effect of layered double hydroxide intercalated with fluoride ions on the physical, biological and release properties of a dental composite resin

Cited by 41 publications

References 32 publications

Layered double hydroxide nanoparticles for biomedical applications: Current status and recent prospects

Layered double hydroxide nanoparticles for biomedical applications: Current status and recent prospects

Biodegradable polymers for dental tissue engineering and regeneration

Long-Term Fluoride Release from Dental Resins Affects STRO-1⁺ Cell Behavior

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Effect of layered double hydroxide intercalated with fluoride ions on the physical, biological and release properties of a dental composite resin

Cited by 41 publications

References 32 publications

Layered double hydroxide nanoparticles for biomedical applications: Current status and recent prospects

Layered double hydroxide nanoparticles for biomedical applications: Current status and recent prospects

Biodegradable polymers for dental tissue engineering and regeneration

Long-Term Fluoride Release from Dental Resins Affects STRO-1+ Cell Behavior

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Product

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Long-Term Fluoride Release from Dental Resins Affects STRO-1⁺ Cell Behavior