Effect of light and temperature on zeta potential and physical stability in solid lipid nanoparticle (SLN™) dispersions

Freitas, C.; Müller, Rainer H.

doi:10.1016/s0378-5173(98)00092-1

Cited by 607 publications

(369 citation statements)

References 3 publications

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“…Thus, whereas a constant value of about +26 mV was found for all concentrations at 37°C, this value decreased from +15 to +6 mV with concentration at 4°C. According to the literature [26][27][28][29] , these values suggest the presence of nano-gels with high and low stability at 37 and at 4°C, respectively. …”

Section: Results and Discussion Dls And Zeta-potential Measurements mentioning

confidence: 95%

Nanogel Formation from Dilute Solutions of Clickable Elastin-like Recombinamers and its Dependence on Temperature: Two Fractal Gelation Modes

Torre

Quintanilla

Pinedo-Martín

et al. 2014

ACS Appl. Mater. Interfaces

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Diluted, complementary, click-reactive elastin-like recombinamer (ELR) solutions have been prepared and mixed at two different temperatures, one below and one above the characteristic transition temperature (T t ) of these chemically modified ELRs. Size, aspect ratio, zeta potential and microrheological measurements have been carried out on the nanostructures formed under these dilute conditions as a way to better understand the relationship between the final macroscopic properties of ELR-based hydrogels and the molecular conditions governing the initial stages of the chemical crosslinking process that occurs, especially its dependence on the preparation temperature relative to T t As a result, two different fractal modes of gel formation have been found at the two temperatures studied (above and below T t ). Thus, when the reaction mixture is prepared below T t , essentially onedimensional linear nanogels with a high aspect ratio are obtained. In contrast, 3D nanogels are formed above T t , with spherical shapes predominating. These different structures seem to reflect the two molecular organizations of the single components of the mixture under these conditions, namely extended chains below T t and a globular arrangement above T t . In addition to the interest in these nanogels as models for understanding the formation of microscopic structures and differential macroscopic properties under more conventional hydrogel-formation conditions, these nanogels are of interest due to their thermoresponsiveness and biocompatibility, which provide them with potential uses for drug delivery and other biomedical applications in living systems. INTRODUCTIONNew materials, many of which are intended for use as gels, especially in the bioscience fields, are continuously coming to the fore.Elastin-like recombinamers (ELRs) are proteinaceous biomaterials based on the repetition of certain sequences from natural elastin 1,2 . These compounds are designed and produced by recombinant DNA technology, thus allowing complete control of their structure and amino acid sequence. ELRs can include different bioactive sequences3, such as those governing protease sensitivity or cell adhesion, etc. These ELRs exhibit cell friendly behavior, tunable mechanical properties, thermal sensitivity and an ability to self-assemble 3,4 . All these properties are interesting for the most cutting-edge applications in the fields of nanotechnology and biomedicine. Their thermal sensitivity is characterized by a critical temperature in aqueous solution, known as the transition temperature (T t ), which is associated with a conformational reorganization at the molecular level. Thus, whereas the polymer chains are soluble in water below T t , they self-assemble into nano-and microaggregates above this temperature, becoming insoluble. This process is completely reversible.We have recently, designed, synthesized, and bioproduced elastin-like recombinamer catalyst-free click gels (ELR-

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Section: Results and Discussion Dls And Zeta-potential Measurements mentioning

confidence: 95%

Nanogel Formation from Dilute Solutions of Clickable Elastin-like Recombinamers and its Dependence on Temperature: Two Fractal Gelation Modes

Torre

Quintanilla

Pinedo-Martín

et al. 2014

ACS Appl. Mater. Interfaces

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“…The increase in the viscosity can slow down the diffusion of lipid particles into the aqueous phase [32] leading to low EE %.…”

Section: Effect Of Drug/lipid Ratio On Nanoparticle Characterizationmentioning

confidence: 99%

The design of naproxen solid lipid nanoparticles to target skin layers

Âkbari

Saeedi

Morteza‐Semnani

et al. 2016

Colloids and Surfaces B: Biointerfaces

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(2016) The design of naproxen solid lipid nanoparticles to target skin layers. Colloids and Surfaces B: Biointerfaces, This version is available from Sussex Research Online: http://sro.sussex.ac.uk/67745/ This document is made available in accordance with publisher policies and may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the URL above for details on accessing the published version. Copyright and reuse:Sussex Research Online is a digital repository of the research output of the University.Copyright and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable, the material made available in SRO has been checked for eligibility before being made available.Copies of full text items generally can be reproduced, displayed or performed and given to third parties in any format or medium for personal research or study, educational, or not-for-profit purposes without prior permission or charge, provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Graphical Abstract Highlights  Naproxen solid lipid nanoparticles (Nap-SLN) can successfully be prepared by ultrasonication  Properties of these nanoparticles can be optimized by lipid concentrations  HLB of the surfactants played a crucial effect on properties of solid lipid nanoparticles  Nap-SLN increased the drug concentration in skin layer rather than systemic absorption Accepted Manuscript AbstractThe aim of the current investigation was to produce naproxen solid lipid nanoparticles (Nap-SLNs) by the ultrasonication method to improve its skin permeation and also to investigate the influence of Hydrophilic-lipophilic balance (HLB) changes on nanoparticles properties. The properties of obtained SLNs loaded with naproxen were characterized by photon correlation spectroscopy (PCS), transmission electron microscopy (TEM) and differential scanning calorimetry (DSC). FT-IR was also used to investigate any interaction between naproxen and the excipients used at the molecular level during the preparation of the SLNs. The performance of the formulations was investigated in terms of skin permeation and also the retention of the drug by the skin. It was found that generally, with increasing the lipid concentration, the average particle size and polydispersity index (PDI) ...

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“…The zeta potential of higher than −60 mV for a colloidal dispersion forecast physically stable condition for the particles of the dispersion. 26 In this investigation, at pH of distilled water (8.3), zeta potential of the selected formulation, F2 and F7, were -14.21 ± 1.14 and -10.08 ± 2.06, respectively (Figure 2).…”

Section: Particle Size and Morphologymentioning

confidence: 99%

Formulation and Physicochemical Characterization of Lycopene-Loaded Solid Lipid Nanoparticles

et al. 2016

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Effect of light and temperature on zeta potential and physical stability in solid lipid nanoparticle (SLN™) dispersions

Cited by 607 publications

References 3 publications

Nanogel Formation from Dilute Solutions of Clickable Elastin-like Recombinamers and its Dependence on Temperature: Two Fractal Gelation Modes

Nanogel Formation from Dilute Solutions of Clickable Elastin-like Recombinamers and its Dependence on Temperature: Two Fractal Gelation Modes

The design of naproxen solid lipid nanoparticles to target skin layers

Formulation and Physicochemical Characterization of Lycopene-Loaded Solid Lipid Nanoparticles

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