Effect of Light Perception on Menarche in Blind Women

Flynn‐Evans, Erin E.; Stevens, Richard G.; Tabandeh, Homayoun; Schernhammer, Eva; Lockley, Steven W.

doi:10.1080/09286580902863056

Cited by 11 publications

(4 citation statements)

References 24 publications

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“…A strong association between puberty timing and risks to develop breast and endometrial cancers in women and prostate cancer in men has been reported [114]. The timing of menarche can also be influenced by light perception: In fact, in blind women, menarche was reported to be earlier with no differences in menopause when compared to sighted women [115].…”

Section: Circadian Clock and Sexual Developmentmentioning

confidence: 99%

Disruption of Circadian Rhythms: A Crucial Factor in the Etiology of Infertility

Sciarra

Franceschini

Campolo

et al. 2020

IJMS

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Infertility represents a growing health problem in industrialized countries. Thus, a greater understanding of the molecular networks involved in this disease could be critical for the development of new therapies. A recent finding revealed that circadian rhythmicity disruption is one of the main causes of poor reproductive outcome. The circadian clock system beats circadian rhythms and modulates several physiological functions such as the sleep-wake cycle, body temperature, heart rate, and hormones secretion, all of which enable the body to function in response to a 24 h cycle. This intricated machinery is driven by specific genes, called “clock genes” that fine-tune body homeostasis. Stress of modern lifestyle can determine changes in hormone secretion, favoring the onset of infertility-related conditions that might reflect disfunctions within the hypothalamic–pituitary–gonadal axis. Consequently, the loss of rhythmicity in the suprachiasmatic nuclei might affect pulsatile sexual hormones release. Herein, we provide an overview of the recent findings, in both animal models and humans, about how fertility is influenced by circadian rhythm. In addition, we explore the complex interaction among hormones, fertility and the circadian clock. A deeper analysis of these interactions might lead to novel insights that could ameliorate the therapeutic management of infertility and related disorders.

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Section: Circadian Clock and Sexual Developmentmentioning

confidence: 99%

Disruption of Circadian Rhythms: A Crucial Factor in the Etiology of Infertility

Sciarra

Franceschini

Campolo

et al. 2020

IJMS

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“…The difference was explained by the fact that humans are active diurnally. 69 A more recent statistical analysis by Flynn-Evans et al 70 was conducted to determine whether differences exist in reproductive measures among blind women (N ¼ 1392) with at least light perception (LP) compared with women with no perception of light (NPL) in a cohort study. Student's two-sample t-tests and multivariate logistic or linear regression were conducted to get statistical results.…”

Section: Step 2: Specific Health Abstractmentioning

confidence: 99%

Daylight and health: A review of the evidence and consequences for the built environment

Aries

Aarts

Hoof

2013

Lighting Research & Technology

200

103

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Daylight has been associated with multiple health advantages. Some of these claims are associations, hypotheses or beliefs. This review presents an overview of a scientific literature search on the proven effects of daylight exposure on human health. Studies were identified with a search strategy across two main databases. Additionally, a search was performed based on specific health effects. The results are diverse and either physiological or psychological. A rather limited statistically significant and well-documented scientific proof for the association between daylight and its potential health consequences was found. However, the search based on specific health terms made it possible to create a first subdivision of associations with daylight, leading to the first practical implementations for building design.

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“…All participants provided informed consent before completing the questionnaire. Further details of the recruitment procedures and survey are described elsewhere [7].…”

Section: Methodsmentioning

confidence: 99%

Total visual blindness is protective against breast cancer

Flynn‐Evans

Stevens

Tabandeh

et al. 2009

Cancer Causes Control

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In multivariate-logistic regression models controlling for breast cancer risk factors, women with NPL had a significantly lower prevalence of breast cancer than women with LP (odds ratio, 0.43; 95% confidence interval, 0.21-0.85). We observed little difference in these associations when restricting to postmenopausal women, non-shift workers or when excluding women diagnosed with breast cancer within 2 or 4 years of onset of blindness. Blind women with NPL appear to have a lower risk of breast cancer, compared to blind women with LP. More research is needed to elucidate the impact of LP on circadian coordination and melatonin production in the blind and how these factors may relate to breast cancer risk.

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Effect of Light Perception on Menarche in Blind Women

Abstract: Our findings suggest that lack of light perception affects reproductive development in women.

Cited by 11 publications

References 24 publications

Disruption of Circadian Rhythms: A Crucial Factor in the Etiology of Infertility

Disruption of Circadian Rhythms: A Crucial Factor in the Etiology of Infertility

Daylight and health: A review of the evidence and consequences for the built environment

Total visual blindness is protective against breast cancer

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