Effect of litter separation on 24-hour rhythmicity of plasma prolactin, follicle-stimulating hormone and luteinizing hormone levels in lactating rabbit does

Cano, Pilar; Jiménez, Vanessa; Álvarez, Mabel; Alvariño, Mario; Cardinali, Daniel P.; Esquifino, Ana I.

doi:10.1186/1740-3391-3-9

Cited by 6 publications

(5 citation statements)

References 23 publications

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“…This behavior in morphometric dynamics of the ovary in relation to the color of the vulva can signal the effect that the weaning stimulus has and the different way in which does respond depending if they are primiparous or multiparous. Furthermore, the intense red of the vulva of the second and third parturition females suggest that they were receptive to males, as shown in previous studies (Díaz et al;Cano et al, 2005;Ola & Oyegbade, 2012).…”

Section: Discussionsupporting

confidence: 77%

Macroscopic Morphometric Analysis of Genital Organs of Rabbit does with Differing Parturitions at 24 Hours Post-weaning

et al. 2013

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SUMMARY:The purpose of this study was to analyze the macroscopic morphometry of the ovaries, uterus and vagina in rabbit does in the first, second and third parturition at 24 hours post-weaning in order to determine if there are differences between parturitions. Weaning of the litter was performed at 30 days post-partum and 24 hours later the does were euthanized. Right and left ovaries, uterine horns-cervix and vagina were removed, and the length of each one was measured. Significant differences were found in the average of the right ovary length between the first group with respect to second and third parturition group (P ≤ 0.05 and P ≤ 0.01). Also, left ovary length was different between the first and second with respect to third parturition group (P <0.001). Average total ovary length increased significantly as the number of parturitions increased in second and third parturition groups (P ≤ 0.01 and P≤0.001). The weight of the left and right ovaries was higher in does in their second and third parturition when compared to those in their first (P≤ 0.5; P≤ 0.01). The average total ovary weight increased significantly as the number of parturitions in second and third parturition groups (P≤0.001). The length of the left and right uterine horn-cervix of the rabbits after second and third parturition decreased when compared to that of females in their first parturition (P≤ 0.05; P≤0.001). The average total uterine horns-cervix length decreased significantly as the number of parturitions in second and third parturition groups (P≤0.001). Furthermore, vagina length in females in their third parturition was greater than that of first and second parturition (P≤ 0.01).The color of the vulva of the majority of females in their first parturition (3/4) was pale pink while. In contrast, the majority of females in their second parturition (3/4) had their vulva intensely red. All of the females (4/4) in the third parturition group had their vulva intensely red. We conclude that in female rabbits the macroscopic morphometric characteristics of ovaries, uterus and vagina, at 24 hours post-weaning vary according to the number of parturitions.

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Section: Discussionsupporting

confidence: 77%

Macroscopic Morphometric Analysis of Genital Organs of Rabbit does with Differing Parturitions at 24 Hours Post-weaning

et al. 2013

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“…Despite the short duration of each nursing bout, the altricial rabbit pups (which are blind for the first 10 days of life) can locate the mother's nipples and suckle milk due to the perception of an olfactory signal that is emitted from the mother's ventrum. In a series of studies we demonstrated that (a) Both in control and in does separated from their litter, plasma level of prolactin changed in a similar way throughout the day showing two maxima, at 05:00-09:00 h and at 17:00-21:00 h, respectively, litter separation significantly augmenting FSH and LH release and disrupting their 24-h rhythmicity in the mother [181]. (b) separation of newborn pups from their mother augmented circulating gonadotropin and PRL levels and disrupted 24-h rhythmicity of their release in pups and to a similar way in both sexes [181][182][183][184].…”

Section: Social Isolationmentioning

confidence: 92%

Neuroendocrine-immune correlates of circadian physiology: studies in experimental models of arthritis, ethanol feeding, aging, social isolation, and calorie restriction

Esquifino

Cano

Jiménez-Ortega

et al. 2007

Endocr

Self Cite

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Virtually all neuroendocrine and immunological variables investigated in animals and humans display biological periodicity. Circadian rhythmicity is revealed for every hormone in circulation as well as for circulating immune cells, lymphocyte metabolism and transformability, cytokines, receptors, and adhesion molecules. Clock genes, notably the three Period (Per1/Per2/Per3) genes and two Cryptochrome (Cry1/Cry2) genes, are present in immune and endocrine cells and are expressed in a circadian manner in human cells. This review discusses the circadian disruption of hormone release and immune-related mechanisms in several animal models in which circulating cytokines are modified including rat adjuvant arthritis, social isolation in rats and rabbits and alcoholism, the aging process and calorie restriction in rats. In every case the experimental manipulation used perturbed the temporal organization by affecting the shape and amplitude of a rhythm or by modifying the intrinsic oscillatory mechanism itself.

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“…Nursing does are affected by a drop in prolactin levels, which may promote the progression of follicular waves and strong steroidogenesis activity, resulting in an increase in the concentration of estradiol-17beta (Ubilla et al, 2000a). By regulating the release of FSH and LH to the increased reaction of the ovulatory response to mating, the litter separation is a proactive strategy to promote ovarian activity (Cano et al, 2005a). The lack of suckling incidents in doe-litter separation may be due to the stimulating effects of ovarian activity, which raises the blood level of estradiol-17beta in does to improve receptivity and fertility.…”

Section: Influence Of Separating Rabbit's Offspring On Doe Blood and ...mentioning

confidence: 99%

“…The authors came to the conclusion that the doe-litter separation group's productivity increased by 35.4-44.2 percent. By altering the secretion of FSH and LH to be connected with the increased impulse of the ovulatory response to mating or by causing the AI process in does to separate from their offspring, Cano et al (2005a) discovered that litter separation is an active strategy to encourage ovarian activity before AI. Young rabbits being taken away from their mothers may put the does under stress and cause a lot of reactive oxygen species to be produced (ROS).…”

Section: Introductionmentioning

confidence: 99%

Effects of Postpartum Separation of Rabbit Offspring from their Mothers on Pregnancy Rate, Milk Production, Behavioral Indicators, Blood Biomarkers of Oxidative Stress, Hormonal Levels, and Performance of Young Rabbits from Birth to Weaning

Habeeb¹,

Kamal²,

Atta³

et al. 2022

JAHP

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The goal of the study was to determine how the 22-hour daily separation of newborn bunnies from their mothers affected the health and ability of doe rabbits to reproduce as well as the survival of the young from birth to weaning. In this study, twenty female New Zealand White (NZW) rabbits were employed, immediately following first parity. The young rabbits were left with their mothers for the first two days after kindling so they could nurse on colostrum. By adding or removing the kits on the third day, the quantity of each litter for each mother was consistent with six, ensuring an equal number of litters at the beginning of the experiment. One of the two groups of animals received a random distribution of female rabbits. Ten does in group one acted as controls and remained with their kits in a group during free lactation (doe-litter together, DLT). In group two, ten does were isolated for 22 hours from their litter (doe-litter separated, DLS). The findings revealed that mothers in the DLS group had a higher (P<0.01) conception rate (28.6%), significantly lower (P<0.05) feed intake, and milk output than mothers in the DLT group. At all experimental ages, the body weight of the separated offspring from their mothers was considerably lower than that of the DLT group (P<0.05). Concentrations of blood biochemical and hormonal levels were affected (P<0.05) due to separation. On day 7, the antioxidant enzyme activities were considerably lower (P<0.05) in the DLS group of rabbits than in the DLT group of animals. It can be inferred that the separation of the kits from their mothers has an impact on the mothers at the beginning of separation while the isolation approach raises the level of the hormone estradiol, which improves the rate of conception.

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Effect of litter separation on 24-hour rhythmicity of plasma prolactin, follicle-stimulating hormone and luteinizing hormone levels in lactating rabbit does

Abstract: Background: This work describes the effect of a 48-h litter separation on 24-h patterns of plasma prolactin, FSH and LH concentration in female lactating rabbits kept under a 16:8 light-dark photoperiod (lights on at 0800 h).

Cited by 6 publications

References 23 publications

Macroscopic Morphometric Analysis of Genital Organs of Rabbit does with Differing Parturitions at 24 Hours Post-weaning

Macroscopic Morphometric Analysis of Genital Organs of Rabbit does with Differing Parturitions at 24 Hours Post-weaning

Neuroendocrine-immune correlates of circadian physiology: studies in experimental models of arthritis, ethanol feeding, aging, social isolation, and calorie restriction

Effects of Postpartum Separation of Rabbit Offspring from their Mothers on Pregnancy Rate, Milk Production, Behavioral Indicators, Blood Biomarkers of Oxidative Stress, Hormonal Levels, and Performance of Young Rabbits from Birth to Weaning

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