“…Of the total of 16 studies, seven presented high risk of bias, 13,24,26,30-33 nine presented unclear risk, 11,12,[17][18][19]25,[27][28][29] and none presented low risk. Two studies presented low risk of bias for 'blinding of personnel', 18,19 six studies did not report whether that domain was assessed, and seven studies did not carry out 'blinding of personnel', 13,24,26,[30][31][32][33] which was the principal risk of bias found. Six studies were classified as having low risk of bias for 'blinding of outcome assessment', 13,18,26,27,31,32 two were classified…”