Effect of magnetic particles adding into nanostructured hydroxyapatite–alginate composites for orthopedics

Sukhodub, L. F.; Sukhodub, Leonid Fedorovych; Pogrebnjak, A.D.; Turlybekuly, Amanzhol; Kistaubayeva, Aida; Savitskaya, Irina; Shokatayeva, D.H.

doi:10.1007/s43207-020-00061-w

Cited by 13 publications

(7 citation statements)

References 36 publications

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“…The dispersion of HA in the alginate solution under the influence of ultrasound followed by crosslinking with Ag + ions makes significant changes in the microstructure of the HA-Alg-Ag composite. Electron microscopic studies show a pronounced contour of the particles, characteristic of similar biocomposites with a matrix of sodium alginate (Pogrebnjak et al 2019b, Turlybekuly et al 2019, Sukhodub et al 2020. The Ca/P weight ratio for these samples is around 1.71 ± 0.10 (0.125 Ag) to 1.73 ± 0.11 (0.25 Ag).…”

Section: Resultsmentioning

confidence: 93%

“…The decreased Ca/P ratio, as compared with the Ca/P ratio for Figure 3 shows scanning transmission electron microscopy (STEM) images of composites together with their diffraction patterns. The particles have a nanoscale needle-shaped form, which is typical of natural HA (see figures 3(a) and (b)) (Elliott 1994, Dorozhkin 2012, Grigolo et al 2016, Pogrebnjak et al 2019a, Sukhodub et al 2020, Turlybekuly et al 2019. When HA is incorporated into the polymer matrix of sodium alginate (the second synthesis method), amorphization of HA nanocrystals is observed, which is confirmed by 'blurring' of the diffraction patterns of crystals as well as by 'rounding' of CaP nanocrystals (figures 3(c) and (d)).…”

Section: Resultsmentioning

confidence: 96%

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Antibacterial and physical characteristics of silver-loaded hydroxyapatite/alginate composites

Sukhodub¹,

Sukhodub²,

Pogrebnjak³

et al. 2021

Funct. Compos. Struct.

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The influence of silver ions on antibacterial properties and morphology of Hydroxyapatite-Ag (HА-Ag) and Hydroxyapatite-Alginate-Ag (HA-Alg-Ag) nanocomposites was studied. The microstructure and phase composition of the obtained nanocomposites were investigated by SEM, TEM, XRD, FTIR methods, and the formation of the crystalline phase of Ag3PO4 was proved. According to the results, silver ions were incorporated into the HA structure, partially replacing calcium ions. The antimicrobial activity assessment was carried out on Gram-negative (Pseudomonas aeruginosa) and Gram-positive bacteria (Staphylococcus aureus) test cultures by the co-incubation and modified «agar diffusion» methods. We have demonstrated that antimicrobial and adhesive properties of both Ag-HA and HA-Alg-Ag are strongly affected by the crystal lattice structure, controlled by silver ions location. The composite materials could be of great interest in the biomedical field, including the design of coatings that prevent or lag the bacterial biofilm development.

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Section: Resultsmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 96%

Antibacterial and physical characteristics of silver-loaded hydroxyapatite/alginate composites

Sukhodub¹,

Sukhodub²,

Pogrebnjak³

et al. 2021

Funct. Compos. Struct.

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“…In a more recent paper, we reported the fabrication of hydrophobic membranes [ 24 ] using a linear diblock copolymer made of methacrylic acid-methyl methacrylate and iron oxide NPs coated with different stabilizers (methacrylic acid and dimercaptosuccinic acid). The use of stabilizers effectively reduced the aggregation of iron oxide NPs as reported in the literature [ 27 , 28 ]. About 16.2% of water permeate flux increase was observed under the magnetic field.…”

Section: Introductionmentioning

confidence: 74%

Block Copolymer-Based Magnetic Mixed Matrix Membranes—Effect of Magnetic Field on Protein Permeation and Membrane Fouling

et al. 2021

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In this study, we report the impact of the magnetic field on protein permeability through magnetic-responsive, block copolymer, nanocomposite membranes with hydrophilic and hydrophobic characters. The hydrophilic nanocomposite membranes were composed of spherical polymeric nanoparticles (NPs) synthesized through polymerization-induced self-assembly (PISA) with iron oxide NPs coated with quaternized poly(2-dimethylamino)ethyl methacrylate. The hydrophobic nanocomposite membranes were prepared via nonsolvent-induced phase separation (NIPS) containing poly (methacrylic acid) and meso-2,3-dimercaptosuccinic acid-coated superparamagnetic nanoparticles (SPNPs). The permeation experiments were carried out using bovine serum albumin (BSA) as the model solute, in the absence of the magnetic field and under permanent and cyclic magnetic field conditions OFF/ON (strategy 1) and ON/OFF (strategy 2). It was observed that the magnetic field led to a lower reduction in the permeate fluxes of magnetic-responsive membranes during BSA permeation, regardless of the magnetic field strategy used, than that obtained in the absence of the magnetic field. Nevertheless, a comparative analysis of the effect caused by the two cyclic magnetic field strategies showed that strategy 2 allowed for a lower reduction of the original permeate fluxes during BSA permeation and higher protein sieving coefficients. Overall, these novel magneto-responsive block copolymer nanocomposite membranes proved to be competent in mitigating biofouling phenomena in bioseparation processes.

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“…Calcium phosphates was mainly used in dentistry and orthopedics as dental fillers, coatings for titanium dental implants, as bone substitutes, and for bone reconstruction and regeneration, due to their excellent biocompatibility, osteoconductive properties, and similarity to the inorganic constituents of human bone [12][13][14][15][16]. This work is devoted to the synthesis and comprehensive study of a biocomposite material based on calcium phosphate doped with ZnCl and AgNO 3 .…”

Section: Introductionmentioning

confidence: 99%

Phase transformations during the doping of zinc chloride and silver nitrate into calcium phosphates

Sagidugumar¹,

Turlybekuly²,

Dogadkin³

et al. 2022

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This article shows the results of a study on a biocomposite material based on calcium phosphate doped with ZnCl and AgNO3 . Calcium phosphates are mainly used in dentistry and orthopedics due to their excellent biocompatibility, osteoconductive properties and similarity to the inorganic components of human bone. The main objective of the study is to investigate the morphology, elemental and phase composition, and physicochemical properties of the obtained material. The test material is obtained in the form of a suspension and subjected to ultrasonic treatment. The microstructure and phase composition of the obtained biocomposites are studied by SEM, XRD, FTIR methods. It is possible to obtain dicalcium phosphate dihydrate (DCPD) by the presented methods, and the results demonstrate a partial replacement of calcium atoms by zinc atoms. Xray phase analysis shows that Ca(HPO4 ) (H2O)2 phases as well as CaZn2 (PO4 )2 (H2O)2 and AgCl phases were formed during the reaction. Fourier transform infrared spectroscopy revealed that the obtained samples contain the groups HPO4 2 and PO4 3 , with the group PO4 2 replacing the group CO3 2 . The biocomposite materials could be of great interest in the biomedical field, including the development of coatings that prevent or delay the development of bacterial biofilm.

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Effect of magnetic particles adding into nanostructured hydroxyapatite–alginate composites for orthopedics

Cited by 13 publications

References 36 publications

Antibacterial and physical characteristics of silver-loaded hydroxyapatite/alginate composites

Antibacterial and physical characteristics of silver-loaded hydroxyapatite/alginate composites

Block Copolymer-Based Magnetic Mixed Matrix Membranes—Effect of Magnetic Field on Protein Permeation and Membrane Fouling

Phase transformations during the doping of zinc chloride and silver nitrate into calcium phosphates

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