Effect of malarial infection on haematological parameters in population near Thailand-Myanmar border

Abstract

BackgroundMalaria is a major mosquito-borne public health problem in Thailand with varied haematological consequences. The study sought to elucidate the haematological changes in people who suspected malaria infection and their possible predictive values of malaria infection.MethodsHaematological parameters of 4,985 patients, including 703 malaria-infected and 4,282 non-malaria infected, who admitted at Phop Phra Hospital, Tak Province, an area of malaria endemic transmission in Thailand during 2009 were evaluated.ResultsThe following parameters were significantly lower in malaria-infected patients; red blood cells (RBCs) count, haemoglobin (Hb), platelets count, white blood cells (WBCs) count, neutrophil, monocyte, lymphocyte and eosinophil counts, while mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), Mean corpuscular haemoglobin concentration (MCHC), neutrophil-lymphocyte ratio (NLR), and monocyte-lymphocyte ratio (MLR) were higher in comparison to non-malaria infected patients. Patients with platelet counts < 150,000/uL were 31.8 times (odds ratio) more likely to have a malaria infection. Thrombocytopenia was present in 84.9% of malaria-infected patients and was independent of age, gender and nationality (P value < 0.0001).ConclusionPatients infected with malaria exhibited important changes in most of haematological parameters with low platelet, WBCs, and lymphocyte counts being the most important predictors of malaria infection. When used in combination with other clinical and microscopy methods, these parameters could improve malaria diagnosis and treatment.

Malaria, Moderate to Severe Anaemia, and Malarial Anaemia in Children at Presentation to Hospital in the Mount Cameroon Area: A Cross-Sectional Study

“…Previous studies have reported a decrease in lymphocyte counts in malaria infection [36, 44]. On the other hand, in line with Lucien et al [45], findings from this study revealed a significantly higher mean granulocyte counts in children with M d SMA with a significant positive relationship between parasite density and the percentage of granulocytes ( P = 0.02).…”

Malaria parasitemia and its association with lipid and hematological parameters among malaria-infected patients attending at Metema Hospital, Northwest Ethiopia

“…16 A previous study has reported pancytopenia as a hematological abnormality caused by malarial infection. 17 This study showed statistically significant differences in WBC and neutrophil count, Hgb, Hct, MCHC, platelets, TC, HDL, TG, and LDL concentrations between malariainfected patients and controls. In terms of WBC indices, there were statistically significant differences in the counts of total WBCs and neutrophils and non-significant decreases in lymphocytes and mixed cell population in case of malariainfected patients compared to the controls (P>0.05).…”

Influência da infecção por Plasmodium vivax nos marcadores hematológicos e hepáticos em pacientes de um município da Região Amazônica brasileira

“…No estudo de Tangpukdee et al 32 , foi exposto ainda que GB foi menor que GV em indivíduos com P. vivax, com aproximação dos valores normais observados no grupo não infectado, após o tratamento, o que vem de encontro aos dados observados neste estudo. A diminuição dos GB é observada no início da infecção, com leucocitose transitória durante os paroxismos febris da malária, estando relacionada à carga parasitária 33,34 .…”