Effect of microemulsion formulation on biodistribution of ^99mTc-Aprotinin in acute pancreatitis models induced rats

Abstract

Background: Aprotinin is a monomeric globular polypeptide, which derived from bovine lung tissue and theoretically attractive molecule in ameliorating the effects of acute pancreatitis. Acute pancreatitis is an inflammatory condition of the pancreas that is painful and at times deadly. Over the following two decades Aprotinin therapeutic potential on pancreatitis is proven experimentally, its clinical therapeutic success is limited due to low targeting to pancreas. Objective: The aim of this study was to evaluate the biodistribution of Technetium-99m ( 99m Tc)-Aprotinin solution ( 99m Tc-Aprotinin-S) and 99m Tc-Aprotinin loaded microemulsion, which was prepared for the aim of treatment for acute pancreatitis. Method: Aprotinin was radiolabeled with 99m Tc. Radiochemical purity was determined with radioactive thin layer chromatography studies.99m Tc-Aprotinin-S and

Drug discovery and formulation development for acute pancreatitis

“…Its application is limited owing to its poor targetability at the pancreas, and it might trigger renal dysfunction when used combined with angiotensin-converting enzyme (ACE) inhibitors (Fritz & Wunderer, 1983 ; Waxler & Rabito, 2003 ; W UK, 2005 ). 99mTc-aprotinin loaded microemulsion (99mTc-aprotinin-M) was designed to increase the targetability for acute pancreatitis treatment (Ilem-Ozdemir et al., 2016 ). The 99mTc-aprotinin solution was also intravenously injected for comparison.…”

Establishment and development of a CZE–UV method for rapid measurement of aprotinin potency

“…Aprotinin has the ability to inhibit trypsin, chymotrypsin, and kallikrein. Therefore, aprotinin has been widely used in clinical treatments, especially for the prevention and treatment of acute pancreatitis , bleeding, and diffusing intravascular coagulation caused by fibrinolysis . It can also be used in the therapy of anti‐shock and other diseases.…”