Effect of microemulsion on liberation of indomethacin from hydrophilic and lipophilic gel

M, Zabka; Hukeľová, M.; Čuchorová, M.; Starýchová, Lenka

doi:10.2478/v10219-012-0018-4

Cited by 2 publications

(3 citation statements)

References 6 publications

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“…The highest percentage of released indomethacin was determined when a mixture of microemulsion gel with higher chitosan content was used. On the basis of our previous study, 29 it can be concluded that this prepared chitosan gel with microemulsion is more suitable for permeation of indomethacin than commercial Indobene Gel R . Chitosan gels could be convenient for the controlled release of drugs.…”

Section: Discussionmentioning

confidence: 74%

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In Vitro Liberation of Indomethacin from Chitosan Gels Containing Microemulsion in Different Dissolution Mediums

Starýchová¹,

M²,

Špaglová³

et al. 2014

Journal of Pharmaceutical Sciences

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The objective of this research is to outline the liberation of indomethacin from different chitosan gels containing O/W microemulsion. The influence of surfactant, sodium lauryl sulfate, in two concentrations (0.5% and 0.75%, w/w) was determined in dissolution medium on the release of indomethacin, which was used as poor water-soluble model drug. Chitosan gels were prepared in four different concentrations of chitosan-1%, 1.5%, 2%, and 3% (w/w). Microemulsion enhanced the liberation of the indomethacin from chitosan gels into all dissolution mediums. Adding the surfactant into phosphate-buffered saline decreased the amount of liberated indomethacin from microemulsion, gel mixture, but increased the drug liberation from pure chitosan gels. It was detected that with the increased concentration of chitosan in the samples, the amount of indomethacin liberated (p < 0.05) also increased. A conclusion was drawn that the liberation of indomethacin from chitosan gels was influenced by increased pH of the samples. The high viscosity induced a higher release of indomethacin from 3% (w/w) chitosan hydrogel at pH 5.8 as compared with 3% (w/w) chitosan hydrogel at pH 3.8. The highest percentage of released indomethacin was determined when a mixture of microemulsion gel with higher chitosan content was used.

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Section: Discussionmentioning

confidence: 74%

“…13 The effect of microemulsion on liberation of indomethacin from hydrophilic (carbopol) and lipophilic gel (aerosil in liquid paraffin) was also evaluated. 29 In this study, chitosan hydrogel formulations containing microemulsion as vehicles for indomethacin as drug were studied.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Liberation of Indomethacin from Chitosan Gels Containing Microemulsion in Different Dissolution Mediums

Starýchová¹,

M²,

Špaglová³

et al. 2014

Journal of Pharmaceutical Sciences

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“…Microemulsions due to their versatile physicochemical attributes like optically clarity, thermodynamic stability and droplet size ranging from 10-140nm stands as delivery of choice for topical dermal application. It can interact with the stratum corneum resulting into the increased permeability due to structural rearrangement lipid layers 1,2 . Skin diseases are result of internal factors like inability of the skin to retain moisture, decrease in Elastin production, less turnover of new skin cells and external factors like lifestyle and environment of the individual like smoking, exposure to sun, exposure to cold, poor diet, too much stress and lack of exercise etc.…”

Section: Introductionmentioning

confidence: 99%

Formulation Development and Evaluation of Microemulsion Gel System of Extract of Tephrosia purpurea for Topical Use.

Vp¹,

Mahendrakumar²,

Bhise³

2015

JCPR

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The ancient knowledge of Ayurveda and drugs of herbal origin can be replicated in to a modern science. The present work elaborates the use of microemulsion drug delivery system of extract of Tephrosia purpurea to treat different skin ailments in better manner. In the present work whole plant of Tephrosia purpurea family; Fabaceae which is also traditionally known as Sharpunkha selected on the basis of traditional claim. The reported constituents of plant are alkaloids, tannins and carbohydrates. These constituents are considered to be having antiinflammatory, and blood purifying activity. The proximate analysis, Preliminary Phytochemical Screening and HPTLC fingerprinting analysis of hydroalcoholic extract of plant was done to confirm the presence of alkaloids and tannins. The extract was formulated in Microemulsion gel with different oil samples and optimized formulation was evaluated for various parameters like appearance, spreadability, pH, viscosity, in-vitro diffusion and antimicrobial study. The optimized formulation exhibited significant results for in vitro drug diffusion, viscosity and antimicrobial activity with acceptable spreadability and elegant appearance. Further study of formulation on specific skin disease using some animal models will explore the use of Tephrosia purpurea in cosmeceuticals.

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Effect of microemulsion on liberation of indomethacin from hydrophilic and lipophilic gel

Cited by 2 publications

References 6 publications

In Vitro Liberation of Indomethacin from Chitosan Gels Containing Microemulsion in Different Dissolution Mediums

In Vitro Liberation of Indomethacin from Chitosan Gels Containing Microemulsion in Different Dissolution Mediums

Formulation Development and Evaluation of Microemulsion Gel System of Extract of Tephrosia purpurea for Topical Use.

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