2013
DOI: 10.1016/j.transci.2013.06.009
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Effect of Mirasol pathogen reduction technology system on in vitro quality of MCS+ apheresis platelets

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Cited by 8 publications
(20 citation statements)
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“…A change of ATP consumption rate is another hypothesis for the increased glycolytic flux in riboflavin/UVB‐treated PLTs. Increased expression of P‐selectin and lower ATP content were reported in riboflavin/UVB‐treated PLTs . We also found an increased expression of CD62P, active GPIIbIIIa at the surface of the PLTs, and an increased adhesion to fibrinogen indicating that the riboflavin/UVB‐treated PLTs were somehow activated upon treatment.…”
Section: Discussionsupporting
confidence: 59%
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“…A change of ATP consumption rate is another hypothesis for the increased glycolytic flux in riboflavin/UVB‐treated PLTs. Increased expression of P‐selectin and lower ATP content were reported in riboflavin/UVB‐treated PLTs . We also found an increased expression of CD62P, active GPIIbIIIa at the surface of the PLTs, and an increased adhesion to fibrinogen indicating that the riboflavin/UVB‐treated PLTs were somehow activated upon treatment.…”
Section: Discussionsupporting
confidence: 59%
“…The results from this study reveal that the riboflavin/UVB treatment significantly impacts the metabolism of PLTs as evidenced by higher glucose consumption and lactate production rates. This phenomenon has been observed by other groups in Mirasol‐treated PLTs . It has been hypothesized that the increased anaerobic glycolysis rate in riboflavin/UVB‐treated PLTs was either due 1) to an impaired mitochondrial functionality leading to a decrease of oxidative phosphorylation, 2) to an alteration of the PLT storage medium characteristics (pH, oxygen content, plasma protein content), or 3) to changes in ATP consumption rate …”
Section: Discussionsupporting
confidence: 59%
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