Effect of Molecular Weight and Ionic Strength on the Formation of Polyelectrolyte Complexes Based on Poly(methacrylic acid) and Chitosan

Vasconcelos, C.L. de; Bezerril, P.M.; Santos, D. E. S. dos; Dantas, Tereza Neuma de Castro; Pereira, M.R.; Fonseca, J. L. C.

doi:10.1021/bm050963w

Cited by 146 publications

(87 citation statements)

References 59 publications

(100 reference statements)

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“…This transformation is an evidence of the formation of chitosan nanoparticles with MAA. According to the mechanism proposed by Vasconcelos et al [12], the formation of nanoparticles occurs via inter and intra-molecular linkages between PMAA carboxyl groups and amino groups of chitosan during the polimerization of MAA. Figure 1 shows a transmission electron microscopy (TEM) image of the chitosan nanoparticles (CS-PMAA).…”

Section: Resultsmentioning

confidence: 99%

A preliminary study of the incorparation of NPK fertilizer into chitosan nanoparticles

Corradini¹,

Moura²,

Mattoso³

2010

Express Polym. Lett.

385

156

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The use of slow release fertilizer has become a new trend to save fertilizer consumption and to minimize environmental pollution. Due to its polymeric cationic, biodegradable, bioabsorbable, and bactericidal characteristics, chitosan (CS) nanoparticle is an interesting material for use in controlled release systems. However, there are no attempts to explore the potential of chitosan nanoparticles as controlled release for NPK fertilizers. In this work chitosan nanoparticles were obtained by polymerizing methacrylic acid for the incorporation of NPK fertilizers. The interaction and stability of chitosan nanoparticle suspensions containing nitrogen (N), phosphorus (P) and potassium (K) were evaluated by FTIR spectroscopy, particle size analysis and zeta-potential. The FTIR results indicated the existence of electrostatic interactions between chitosan nanoparticles and the elements N, P and K. The stability of the CS-PMAA colloidal suspension was higher with the addition of nitrogen and potassium than with the addition of phosphorus, due to the higher anion charge from the calcium phosphate than the anion charges from the potassium chloride and urea. The mean diameter increase of the CS-PMAA nanoparticles in suspension with the addition of different compounds indicated that the elements are being aggregated on the surface of the chitosan nanoparticles

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Section: Resultsmentioning

confidence: 99%

A preliminary study of the incorparation of NPK fertilizer into chitosan nanoparticles

Corradini¹,

Moura²,

Mattoso³

2010

Express Polym. Lett.

385

156

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“…The preparation of PEC nanoparticles is quite simple and can be easily performed under mild conditions without the use of toxic organic reagents. It has been demonstrated that chitosan can form PEC nanoparticles with various polyanions such as hyaluronic acid, chondroitin sulfates, alginate, carboxymethyl cellulose, carrageenan, heparin, and poly(acrylic acid) [84][85][86]. Recently, chitosan has been investigated as the carrier of a hydrophilic 5-FU by forming PEC nanoparticles with polyaspartic acid sodium salt [87].…”

Section: Chitosan-based Polyelectrolyte Complex (Pec) Nanoparticlesmentioning

confidence: 99%

Chitosan Mediated Targeted Drug Delivery System: A Review

Patel¹,

Patel²,

Patel³

2010

J Pharm Pharm Sci

235

166

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-Chitosan has prompted the continuous movement for the development of safe and effective drug delivery systems because of its unique physicochemical and biological characteristics. The primary hydroxyl and amine groups located on the backbone of chitosan allow for chemical modification to control its physical properties. When the hydrophobic moiety is conjugated to a chitosan molecule, the resulting amphiphile may form self-assembled nanoparticles that can encapsulate a quantity of drugs and deliver them to a specific site of action. Chemical attachment of the drug to the chitosan throughout the functional linker may produce useful prodrugs, exhibiting the appropriate biological activity at the target site. Mucoadhesive and absorption enhancement properties of chitosan increase the in vivo residence time of the dosage form in the gastrointestinal tract and improve the bioavailability of various drugs. The main objective of this review is to provide an insight into various target-specific carriers, based on chitosan and its derivatives. The first part of the review is concerned with the organ-specific delivery system using chitosan and its derivatives. The subsequent section considers the recent developments of drug delivery carriers for cancer therapy with special focus on various targeting strategies. __________________________________________________________________________________________

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“…The potential of combining two or more desirable properties by tailoring the material opens up a vast array of new possibilities (Decher 1997;de Vasconcelos et al 2006). The use of polyelectrolyte complexes (PECs), or polyelectrolyte multilayers (PEMs) have received quite a lot of attention in the field of research (Philipp et al 1989;Dautzenberg 1997;Decher 1997;Dautzenberg and Karibyants 1999).…”

Section: Introductionmentioning

confidence: 99%

“…The properties and behavior of PECs in suspension has previously been studied by measurements of turbidity, static light scattering, dynamic light scattering, polyelectrolyte titration, viscosity, surface charge analysis, FTIR spectroscopy, and electrophoretic mobility (Buchhammer et al 1995;Dautzenberg 1997;Dautzenberg and Karibyants 1999;Dragan and Cristea 2001;Kekkonen et al 2001;Hubbe et al 2005;de Vasconcelos et al 2006). It has been reported that the formation of PECs is sensitive towards the nature of the cationic polyelectrolyte .…”

Section: Introductionmentioning

confidence: 99%

In-situ analysis of polyelectrolyte complexes by flow cytometry

et al. 2018

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Polyelectrolyte complexes (PECs) from common papermaking additives were prepared at different cation/anion ratios, resulting in colloidal light scattering particles. The polycations were cationic starches and polyDADMACs, while the polyanions were different carboxymethyl celluloses. The PECs were studied by turbidity measurements, as well as by flow cytometry (FCM). Turbidity maxima were detected close to the theoretical neutralization point of the polycation and polyanion. The turbidity response of the PEC mixtures varied with polyelectrolyte charge density. The PECs were in most cases quite stable over 24 h, but certain combinations resulted in unstable particles over time. Flow cytometry of PECs revealed clear populations of hydrophilic particles. The light scattering properties of PECs in side direction (SSC) and forward direction (FSC) were recorded for the different PEC combinations. The determined FSC and SSC offered information about very different PEC properties, and a new term was suggested for better understanding the mechanisms behind PEC formation; FSC/SSC. It was suggested that the determined FSC/SSC values were connected to the structural density of different particles. The premise was tested by analyses of solid, dense particles as well as swollen, soft particles. In addition to this, the hydrophobicity of PECs was determined by FCM. It was seen that the PECs were quite hydrophilic overall and that the measured hydrophobicities were lowest around the theoretical point of neutralization. Finally, the behavior of a coagulating PEC mixture as a function of contact time was studied with FCM.

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Effect of Molecular Weight and Ionic Strength on the Formation of Polyelectrolyte Complexes Based on Poly(methacrylic acid) and Chitosan

Cited by 146 publications

References 59 publications

A preliminary study of the incorparation of NPK fertilizer into chitosan nanoparticles

A preliminary study of the incorparation of NPK fertilizer into chitosan nanoparticles

Chitosan Mediated Targeted Drug Delivery System: A Review

In-situ analysis of polyelectrolyte complexes by flow cytometry

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