Effect of Multiple Exposure to Perfluorinated Chemicals on Thyroid Function among Adults in the US: The National Health and Nutrition Examination Survey 2007-2008 and 2011-2012

Sohn, Young Seok; Moon, Shinje; Park, Young Joo

doi:10.11106/ijt.2020.13.1.19

Cited by 3 publications

(1 citation statement)

References 33 publications

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“…Many studies have tested the effect of PFASs on thyroid hormone homeostasis in healthy adults. The results were inconsistent and showed no effect [ 254 , 345 , 391 , 392 , 393 , 394 , 395 , 396 , 397 , 398 , 399 , 400 , 401 , 402 , 403 , 404 ], increase [ 254 , 401 , 405 , 406 ] or decrease [ 344 , 398 ] in TSH levels after exposure to PFASs. No effect [ 254 , 345 , 398 , 399 ], increase [ 254 , 392 , 395 , 396 , 397 , 402 , 404 , 406 ] or decrease [ 344 , 401 , 406 ] in T3 levels and no effect [ 254 , 393 , 395 , 396 , 397 , 399 , 404 , 406 ], increase [ 254 , 344 , 345 , 394 , 397 , ...…”

Section: Environmental Factors That Influence Tsh and Thyroid Hormone Levelsmentioning

confidence: 99%

Environmental Factors Affecting Thyroid-Stimulating Hormone and Thyroid Hormone Levels

Leko

Gunjača

Pleić

et al. 2021

IJMS

132

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Thyroid hormones are necessary for the normal functioning of physiological systems. Therefore, knowledge of any factor (whether genetic, environmental or intrinsic) that alters the levels of thyroid-stimulating hormone (TSH) and thyroid hormones is crucial. Genetic factors contribute up to 65% of interindividual variations in TSH and thyroid hormone levels, but many environmental factors can also affect thyroid function. This review discusses studies that have analyzed the impact of environmental factors on TSH and thyroid hormone levels in healthy adults. We included lifestyle factors (smoking, alcohol consumption, diet and exercise) and pollutants (chemicals and heavy metals). Many inconsistencies in the results have been observed between studies, making it difficult to draw a general conclusion about how a particular environmental factor influences TSH and thyroid hormone levels. However, lifestyle factors that showed the clearest association with TSH and thyroid hormones were smoking, body mass index (BMI) and iodine (micronutrient taken from the diet). Smoking mainly led to a decrease in TSH levels and an increase in triiodothyronine (T3) and thyroxine (T4) levels, while BMI levels were positively correlated with TSH and free T3 levels. Excess iodine led to an increase in TSH levels and a decrease in thyroid hormone levels. Among the pollutants analyzed, most studies observed a decrease in thyroid hormone levels after exposure to perchlorate. Future studies should continue to analyze the impact of environmental factors on thyroid function as they could contribute to understanding the complex background of gene–environment interactions underlying the pathology of thyroid diseases.

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Section: Environmental Factors That Influence Tsh and Thyroid Hormone Levelsmentioning

confidence: 99%

Environmental Factors Affecting Thyroid-Stimulating Hormone and Thyroid Hormone Levels

Leko

Gunjača

Pleić

et al. 2021

IJMS

132

View full text Add to dashboard Cite

show abstract

Exposure to mixed chemicals elevated triiodothyronine (T3) and follicle-stimulating hormone (FSH) levels: epidemiology and in silico toxicogenomic involvement

Nguyen

2023

Environ Sci Pollut Res

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Statewide sampling to determine spatial distribution, prevalence, and occurrence of per- and polyfluoroalkyl substances (PFAS) in Illinois community water supplies, 2020–21

Gahala,

Sharpe,

Williams

2023

Scientific Investigations Report

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Effect of Multiple Exposure to Perfluorinated Chemicals on Thyroid Function among Adults in the US: The National Health and Nutrition Examination Survey 2007-2008 and 2011-2012

Cited by 3 publications

References 33 publications

Environmental Factors Affecting Thyroid-Stimulating Hormone and Thyroid Hormone Levels

Environmental Factors Affecting Thyroid-Stimulating Hormone and Thyroid Hormone Levels

Exposure to mixed chemicals elevated triiodothyronine (T3) and follicle-stimulating hormone (FSH) levels: epidemiology and in silico toxicogenomic involvement

Statewide sampling to determine spatial distribution, prevalence, and occurrence of per- and polyfluoroalkyl substances (PFAS) in Illinois community water supplies, 2020–21

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