Effect of Multiple Sclerosis and Its Treatments on Male Fertility: Cues for Future Research

Massarotti, Claudia; Sbragia, Elvira; Gazzo, Irene; Stigliani, Sara; Inglese, Matilde; Anserini, Paola

doi:10.3390/jcm10225401

Cited by 13 publications

(7 citation statements)

References 107 publications

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“…Other explanations encompass a reduction in sex hormone levels due to neuronal damage or chronic inflammation as well as the direct impact of autoimmune pathology on semen quality. It is even worse that the side effects of anti-anxiety and antidepressant medications might further diminish erectile and ejaculatory functions ( 38 , 39 ).…”

Section: Autonomic Nervous System Disorders and Male Infertilitymentioning

confidence: 99%

Effects of autonomic nervous system disorders on male infertility

Qiu,

Chen,

et al. 2023

Front. Neurol.

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The male reproductive functions are largely regulated by the autonomic nervous system. Male sexual behavior and fertility primarily depend on the normal function of the higher neural centers related to the autonomic nervous system, the hypothalamic–pituitary–gonadal axis, the autonomic nervous components within the spinal cord and spinal nerves, and certain somatic nerves in the pelvic floor. In this review article, we will summarize the role of the autonomic nervous system in regulating male reproductive capabilities and fertility, its impact on male infertility under abnormal conditions, including the role of drug-induced autonomic nervous dysfunctions on male infertility. The main purpose of this article was to provide an overview of the effects of autonomic nervous dysfunction on male reproductive function and shed light on the potential therapeutic target for male infertility.

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Section: Autonomic Nervous System Disorders and Male Infertilitymentioning

confidence: 99%

Effects of autonomic nervous system disorders on male infertility

Qiu,

Chen,

et al. 2023

Front. Neurol.

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“…Сексуальна дисфункція та погіршення якості сперми також можуть виникати внаслідок побічних ефектів від лікування. Так, наприклад, бензодіазепіни та трициклічні антидепресанти, що використовують у симптоматичному лікуванні, можуть також впливати на статеву функцію [29].…”

Section: а к т у а л ь н і т е м иunclassified

Multiply sclerosis and fertility

Kotsiuba,

Chabanova,

Shulga

et al. 2023

RHW

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The article is a review of modern scientific publications, which are devoted to the problems of fertility and disorders of reproductive functions in patients with multiple sclerosis, the direct impact of this disease and disease-modifying therapy on human reproductive health.Multiple sclerosis belongs to autoimmune neurodegenerative diseases, which today remains the leading cause of non-traumatic disability and leads to the formation of permanent physical defects, cognitive disorders and a decrease of the quality of life. Every year an increased number of people are diagnosed with multiple sclerosis, especially among the young persons of reproductive age, because the debut of the disease falls between the ages of 20 and 40 years.This pathology affects both women and men. Moreover, it should be noted that there are twice more women with multiple sclerosis than men, and the reason for this «phenomenon» remains unknown for certain. It is also unclear why the course and manifestations of the disease differ among individuals of different sexes. Multiple sclerosis has a significant impact on all areas of a person’s life, limiting his capabilities.For many years, it was believed that pregnancy is harmful for women with multiple sclerosis, so doctors did not recommend pregnancy due to the fear that patients would not be able to care for their children due to significant worsening of the disease and progression of disability. And that’s why today among patients, both male and female, fears often arise regarding: the effect of this disease and the drugs used in the treatment of multiple sclerosis on fertility; safety and risks during pregnancy and the postpartum period; possibilities and effectiveness of using assisted reproductive technologies as needed.A rather important step for a patient with multiple sclerosis is family planning, which should include counseling on the choice of contraceptive methods, drugs for disease-modifying and symptomatic therapy, a multidisciplinary approach to pregnancy management in such patients in order to optimize treatment and minimize all possible negative effects to ensure the best result

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“…Despite the recognized value of sexual and reproductive health in MS, data on these domains are sparse, mostly based on cross-sectional or retrospective studies, and from periods before the availability of newer high-efficacy DMTs [ 14 – 22 ]. Newer DMTs such as B-cell-depleting drugs have different safety profiles than predecessors, and their teratogenic potential is mostly unknown or investigated with ongoing monitoring [ 21 ]. In addition, the longitudinal effects of common MS comorbidities on sexual and reproductive health in MS populations remain severely understudied.…”

Section: Introductionmentioning

confidence: 99%

Male sexual and reproductive health in multiple sclerosis: a scoping review

Toljan,

Briggs

2024

J Neurol

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Background Multiple sclerosis (MS) is a chronic neuroinflammatory disease with highest incidence during the period of optimal reproductive health. This scoping review aimed to identify and summarize available data on sexual/reproductive health in males with MS (MwMS). Methods This review was based on PRISMA extension for Scoping Review. PubMed database was searched for keyword “multiple sclerosis” alongside keywords “sexual health”, “reproductive health”, “family planning”, “male fertility”, “male infertility”, “sexual dysfunction”, and “erectile dysfunction”, iteratively using the “AND” logical operator. Descriptive analysis was performed on the included articles. Results Thirty-four studies were included, and four topics emerged: sexual dysfunction, erectile dysfunction, fertility, and family planning. Sexual dysfunction is common in MwMS (35–72%), yet only a minority of MwMS discuss their sexual health with their treatment teams. Both MS disability and depression were associated with sexual dysfunction in MwMS, with erectile dysfunction and decreased libido as the most prevalent aspects of sexual dysfunction. Positively, phosphodiesterase-5 inhibitors appear effective for treating erectile dysfunction and improving sexual quality of life in MwMS. There may also be a relationship between MS and male infertility, though changes in sexual behavior may underlie this association. Finally, a prominent knowledge gap was observed for disease-modifying therapy use and family planning in MwMS. Conclusion Sexual dysfunction is common, impacted by MS severity, and associates with decreased quality of life in MwMS. Communication barriers regarding sexual and reproductive health appear to exist between MwMS and providers, as do literature gaps related to MS therapeutics and sexual/reproductive health.

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Effect of Multiple Sclerosis and Its Treatments on Male Fertility: Cues for Future Research

Cited by 13 publications

References 107 publications

Effects of autonomic nervous system disorders on male infertility

Effects of autonomic nervous system disorders on male infertility

Multiply sclerosis and fertility

Male sexual and reproductive health in multiple sclerosis: a scoping review

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