1992
DOI: 10.1159/000182535
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Effect of Naloxone Administration upon the Diurnal Concentrations of Oxytocin in the Cerebrospinal Fluid of Rhesus and Cynomolgus Monkeys

Abstract: A diurnal pattern in oxytocin concentrations is present in cerebrospinal fluid (CSF) removed from the spinal subarachnoid space of monkeys, with elevated levels occurring in the early light hours. In order to investigate the possible role of endogenous opioid peptides in the generation of this oxytocin rhythm, we administered naloxone (0.4 mg/kg/h × 48 h) to rhesus and cynomolgus monkeys and examined the effects on the diurnal pattern of oxytocin in CSF collected from the lumbar subarachnoid spinal space. Monk… Show more

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