Effect of Oleanolic Acid on Apoptosis and Autophagy of SMMC-7721 Hepatoma Cells

Zhou, Weipeng; Zeng, Xianjun; Wu, Xiaoping

doi:10.12659/msm.921606

Cited by 19 publications

(19 citation statements)

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“… 18 As another example, Oleanolic acid attenuates the development of HCC by inducing autophagy and promoting apoptosis. 19 TEH, along with the other 2 ingredients (tenacissoside I and G), is extracted form Marsdenia tenacissima and has been found with anti-inflammatory and anti-tumor effects. 20 Interestingly, a recent study proved that the Marsdenia tenacissima extract (MTE) promotes gefitinib accumulation in lung cancer tissues via fasciliating the activities of ABCG2, which is the primary drug transporter for gefitinib.…”

Section: Discussionmentioning

confidence: 99%

Tenacissoside H Induces Autophagy and Radiosensitivity of Hepatocellular Carcinoma Cells by PI3K/Akt/mTOR Signaling Pathway

et al. 2021

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Tenacissoside H (TEH), which has anti-inflammatory and anti-tumor effects, is a major active ingredient extracted from the stem of Marsdenia tenacissima. However, the effect of TEH on hepatocellular carcinoma (HCC) as well as the underlying mechanisms are still indistinct. Presently, HCC cells (including Huh-7 and HepG2) were dealt with different concentrations of TEH. The proliferation and apoptosis of HCC cells were determined via Cell Counting Kit-8 (CCK8) assay and flow cytometry. In addition, Western blot was conducted to evaluate the expressions of autophagy—and apoptosis-related proteins. Tissue immunofluorescence was carried out to evaluate LC3B expression in the tumor tissues. The data showed that TEH suppressed the growth of HCC cells in a concentration-dependent manner. Besides, TEH enhanced radiosensitivity and promoted the apoptosis of HCC cells. Moreover, the mRNA and protein levels of autophagy-related genes (LC3-II/LC2-I, ATG5, Beclin-1) were significantly promoted by TEH. Mechanistically, TEH attenuated the activation of PI3K/Akt/mTOR signaling pathway. However, inhibition of PI3 K pathway abolished the anti-tumor effects of TEH in HCC cells. Collectively, this study suggested that TEH increases the radiosensitivity of HCC cells via inducing autophagy and apoptosis through downregulating PI3K/Akt/mTOR signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Tenacissoside H Induces Autophagy and Radiosensitivity of Hepatocellular Carcinoma Cells by PI3K/Akt/mTOR Signaling Pathway

et al. 2021

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“…Betulinic acid showed significant PTP1B inhibitory activity, with IC 50 values of 3.5 μM [24]. [54] Anti-hypertension (in vivo) [55] Anti-tumor (in vitro) [56,57] Neuroprotection(in vitro) [58] Anti-cholesterol(in vitro) […”

Section: Lupane Triterpenoidsmentioning

confidence: 99%

“…It was found from callus tissue from the stems of A. arguta , together with 2 α ,3 β -dihydroxyolean-12-en-28-oic acid 78 [ 26 ]. Oleanolic acid 77 is abundant in nature and exhibits a wide range of biological activities including anti-inflammatory [ 54 ], anti-hypertension [ 55 ], anti-tumor [ 56 , 57 ], neuroprotection [ 58 ], and anti-cholesterol activities [ 59 ]. Oleanolic acid was performed to test the effect on apoptosis and autophagy of SMMC-7721 Hepatoma cells.…”

Section: Chemical Constituentsmentioning

confidence: 99%

“…Oleanolic acid was performed to test the effect on apoptosis and autophagy of SMMC-7721 Hepatoma cells. It can significantly inhibit the growth of liver cancer SMMC-7721 cells and induce autophagy and apoptosis [ 57 ]. Compound 78 also showed anti-tumor and anti-inflammatory activities [ 60 , 61 ].…”

Section: Chemical Constituentsmentioning

confidence: 99%

“… Part Bioactivity Refs. 77 Oleanolic acid A. arguta [ 26 ] Stems Anti-inflammatory (in vitro) [ 54 ] Anti-hypertension (in vivo) [ 55 ] Anti-tumor (in vitro) [ 56 , 57 ] Neuroprotection(in vitro) [ 58 ] Anti-cholesterol(in vitro) [ 59 ] 78 2 α ,3 β -Dihydroxyolean-12-en-28-oic acid A. arguta [ 26 ] Stems 79 2 α ,3 α -Dihydroxyolean-12-en-28-oic acid A. chinensis Planch [ 63 ] Fruits 80 2 α ,3 β ,23-Trihydroxyolean-12-en-28-oic acid A. deliciosa [ 31 ] Peels Antifungal (in vitro) [ 31 ] 81 2 α ,3 α ,24-Trihydroxyolean-12-en-28-oic acid A. deliciosa [ 31 ] Peels Antifungal (in vitro) [ 31 ] 82 3 β -O-Acetyloleanolic acid A. arguta [ 64 ] A. chinensis [ 45 ] Stems Roots Anti-angiogenesis (in vitro) [ 45 ] 83 …”

Section: Chemical Constituentsmentioning

confidence: 99%

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Advances in Research on Chemical Constituents and Their Biological Activities of the Genus Actinidia

Liu

et al. 2021

Nat. Prod. Bioprospect.

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Kiwi, a fruit from plants of the genus Actinidia, is one of the famous fruits with thousand years of edible history. In the past twenty years, a great deal of research has been done on the chemical constituents of the Actinidia species. A large number of secondary metabolites including triterpenoids, flavonoids, phenols, etc. have been identified from differents parts of Actinidia plants, which exhibited significant in vitro and in vivo pharmacological activities including anticancer, anti-inflammatory, neuroprotective, anti-oxidative, anti-bacterial, and anti-diabetic activities. In order to fully understand the chemical components and biological activities of Actinidia plants, and to improve their further research, development and utilization, this review summarizes the compounds extracted from different parts of Actinidia plants since 1959 to 2020, classifies the types of constituents, reports on the pharmacological activities of relative compounds and medicinal potentials.

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Therapeutic Potential of Terpenoids in Cancer Treatment: Targeting Mitochondrial Pathways

Guo,

Huang,

Hou

et al. 2024

Cancer Reports

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BackgroundIn recent decades, natural compounds have been considered a significant source of new antitumor medicines due to their unique advantages. Several in vitro and in vivo studies have focused on the effect of terpenoids on apoptosis mediated by mitochondria in malignant cells.Recent findingsIn this review article, we focused on six extensively studied terpenoids, including sesquiterpenes (dihydroartemisinin and parthenolide), diterpenes (oridonin and triptolide), and triterpenes (betulinic acid and oleanolic acid), and their efficacy in targeting mitochondria to induce cell death. Terpenoid‐induced mitochondria‐related cell death includes apoptosis, pyroptosis, necroptosis, ferroptosis, autophagy, and necrosis caused by mitochondrial permeability transition. Apoptosis and autophagy interact in meaningful ways. In addition, in view of several disadvantages of terpenoids, such as low stability and bioavailability, advances in research on combination chemotherapy and chemical modification were surveyed.ConclusionThis article deepens our understanding of the association between terpenoids and mitochondrial cell death, presenting a hypothetical basis for the use of terpenoids in anticancer management.

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Effect of Oleanolic Acid on Apoptosis and Autophagy of SMMC-7721 Hepatoma Cells

Cited by 19 publications

References 43 publications

Tenacissoside H Induces Autophagy and Radiosensitivity of Hepatocellular Carcinoma Cells by PI3K/Akt/mTOR Signaling Pathway

Tenacissoside H Induces Autophagy and Radiosensitivity of Hepatocellular Carcinoma Cells by PI3K/Akt/mTOR Signaling Pathway

Advances in Research on Chemical Constituents and Their Biological Activities of the Genus Actinidia

Therapeutic Potential of Terpenoids in Cancer Treatment: Targeting Mitochondrial Pathways

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