Effect of oral azithromycin in the treatment of chlamydial conjunctivitis

Chen, Yan-Ming; Hu, Fung-Rong; Hou, Yu-Chih

doi:10.1038/eye.2009.264

Cited by 17 publications

(20 citation statements)

References 21 publications

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“…Adult chlamydial conjunctivitis is treated systemically by doxycycline or, alternatively, erythromycin or azithromycin in pregnant or lactating woman [11,51]. Adjunctive topical tetracycline or erythromycin may also be prescribed.…”

Section: Chlamydial Conjunctivitismentioning

confidence: 99%

Conjunctivitis: Systematic Approach to Diagnosis and Therapy

Thanathanee

O’Brien

2011

Curr Infect Dis Rep

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Conjunctivitis is a common problem in primary health care. Inflammation of the conjunctiva may result from infection or noninfectious causes. Microbial conjunctivitis may be caused by bacteria, viruses, or parasites. Although usually a benign, self-limited disease in healthy individuals, serious complications (eg, keratitis) may be sight-threatening. Accurate diagnosis and specific treatment of conjunctivitis remain challenging. History taking and physical examination are occasionally insufficient for correct diagnosis, thus laboratory testing may play a vital role in identification of specific pathogen(s). However, diagnostic testing has several limitations, including time-consuming methods, increased cost, and requirement for expertise in performance and interpretation. Treatment with empirical topical antibiotics for suspected infectious conjunctivitis is controversial. Although antibiotic treatment can diminish risk of adverse events and shorten the course of disease, drug resistance, toxicity, and expense are important considerations in management of acute infectious conjunctivitis.

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Section: Chlamydial Conjunctivitismentioning

confidence: 99%

Conjunctivitis: Systematic Approach to Diagnosis and Therapy

Thanathanee

O’Brien

2011

Curr Infect Dis Rep

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“…Similar approaches for both chlamydial and gonococcal conjunctivitis are reported in the literature with the vast majority of cases responding well to these agents. 10 , 11 , 12 , 13 In the United States the American Academy of Ophthalmology (AAO) published a Preferred Practice Pattern for Conjunctivitis. 14 They recommend that adults treated for gonococcal conjunctivitis be routinely treated with medication effective against Chlamydia trachomatis because patients are often co-infected.…”

Section: Discussionmentioning

confidence: 99%

Adult conjunctivitis secondary to dual infection with Chlamydia trachomatis and Neisseria gonorrhoeae - A case report

Linton

Hardman

Welburn

et al. 2019

American Journal of Ophthalmology Case Reports

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PurposeAlthough Chlamydia trachomatis and Neisseria gonorrhoeae are the commonest sexually transmitted infections in England, reports of ocular co-infection in the literature are limited. We report such a case which responded well to treatment, and discuss the literature and evidence currently available with regards to management of these cases.ObservationsThe patient is a 48-year-old bisexual gentleman who presented to the eye clinic of a UK hospital with redness, discharge and blurred vision in his left eye for one week. Initially he had mucopurulent discharge but his cornea was clear. He did not comply with prescribed treatment and returned two days later with bilateral symptoms and corneal thinning in his left eye peripherally.PCR tests for Chlamydia trachomatis and Neisseria gonorrhoeae were positive and the patient was commenced on intravenous ceftriaxone, oral and topical levofloxacin eye drops. After 48 hours of inpatient treatment the patient showed clinical improvement.Conclusions and importanceOphthalmologists should be aware of the possibility that Chlamydia trachomatis and Neisseria gonorrhoeae can cause co-infection in adult conjunctivitis, and of the straightforward method of treatment for such individuals. Delayed diagnosis and treatment of affected patients can lead to corneal complications and potential blindness. It is advisable to discuss these cases with the local microbiology service wherever possible, and referral to a sexual health service is imperative.

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“…Treatment regimens used included single-dose azithromycin or 2 weeks of doxycycline. [19][20][21] It was noted that those who received treatment by the ophthalmologist were still less likely to attend follow-up. This reinforced our belief that such patients require the incentive of treatment to encourage them to attend the sexual health services.…”

Section: Discussionmentioning

confidence: 99%