Effect of oral nutritional supplementation on growth and recurrent upper respiratory tract infections in picky eating children at nutritional risk: a randomized, controlled trial

Ghosh, Apurba; Kishore, Bala; Shaikh, Irfan Ahmed; Satyavrat, Vinita; Kumar, Anil; Shah, Tapan; Pote, P D; Shinde, Sandeep; Berde, Yatin; Low, Yen Ling; Tan, Verena M. H.; Huynh, Dieu Thi Thu

doi:10.1177/0300060518757355

Cited by 18 publications

(55 citation statements)

References 24 publications

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“…A meta-analysis using the longest followup time point showed that children in the ONS group had significantly greater catch-up growth in height (0.417 [0.059, 0.776] cm, p = 0.022), HAZ (0.041 [0.007, 0.074], p = 0.018), and HAP (2.167 [0.718, 3.616], p = 0.003) compared with the control group (Figure 4). Five RCTs (Alarcon [23], Khanna [57], Ghosh [50], Han [48], and Sheng [49]), along with Cervo [53] on height (cm) and Rawat [58] on HAZ, reported change in height parameters within a period of 30-90 days of ONS intervention (Figure 5). When compared with the control, the ONS group trended towards a greater catch-up in height in 90 days (0.322 cm [−0.008, 0.653], p = 0.056) and had significantly greater gains in HAP in 30 days (1.003 [0.372, 1.633], p = 0.002) as well as at 60 and 90 days and HAZ in 90 days (0.053 [0.018, 0.088], p = 0.003).…”

Section: Results For Height Parameters: Change In Height and Height-for-agementioning

confidence: 99%

“…Eleven studies met the inclusion criteria ( Figure 1 ). Of these, seven were considered to be of “high” quality [ 23 , 47 , 48 , 49 , 50 , 51 , 52 ] and two each “moderate” [ 53 , 54 ] and “low” [ 55 , 56 ] quality ( Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…Three studies (Lebenthal [51], Sheng [49], and Cervo [53]) had a higher risk for attrition bias due to higher drop-out rates. Seven studies (Walker [54], Schrezenmier [47], Han [48], O'Reilly [55], Cervo [53], Ghosh [50], and Vijayalakshmi [56]) were at high risk of performance bias for subjects, researchers, or both, for being unblinded to treatment group assignment. Eight studies (Alarcon [23], Cervo [53], Khanna [57], Ghosh [50], Han [48], Schrezenmeir [47], Sheng [49], and Walker [54]) reported outcomes in weight gain ("catch-up weight") from baseline (Figure 2a).…”

Section: Quality Of Included Studies and Risk Of Biasmentioning

confidence: 99%

“…Six and five studies, respectively, reported changes in weight-for-age and weight-forheight data (Figure 2b-e Three studies (Khanna [57], Ghosh [50], and Schrezenmeir [47]) reported change in weight within 7-10 days of ONS intervention. A significantly greater weight gain (0.089 [0.049, 0.130] kg, p < 0.001) was observed in 7-10 days of intervention in the ONS group compared with the control group Supplementary Figure S2).…”

Section: Quality Of Included Studies and Risk Of Biasmentioning

confidence: 99%

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Effect of Oral Nutritional Supplementation on Growth in Children with Undernutrition: A Systematic Review and Meta-Analysis

Zhang

Hannon

et al. 2021

Nutrients

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Oral nutritional supplements (ONS) are used to promote catch-up growth in children with undernutrition. We conducted a systematic review and meta-analysis to summarize the evidence of ONS intervention effects on growth for 9-month- to 12-year-old children who were undernourished or at nutritional risk. Eleven randomized controlled trials met the inclusion criteria; trials compared changes in anthropometric measures in children using ONS or ONS + DC (dietary counselling) to measures for those following usual diet or placebo or DC alone. The RCTs included 2287 children without chronic diseases (mean age 5.87 years [SD, 1.35]; 56% boys). At follow-up time points up to 6 months, results showed that children in the ONS intervention group had greater gains in weight (0.423 kg, [95% confidence interval 0.234, 0.613], p < 0.001) and height (0.417 cm [0.059, 0.776], p = 0.022) versus control; greater gains in weight (0.089 kg [0.049, 0.130], p < 0.001) were evident as early as 7–10 days. Longitudinal analyses with repeated measures at 30, 60, and 90 days showed greater gains in weight parameters from 30 days onwards (p < 0.001), a trend towards greater height gains at 90 days (p = 0.056), and significantly greater gains in height-for-age percentiles and z-scores at 30 and 90 days, respectively (p < 0.05). Similar results were found in subgroup analyses of studies comparing ONS + DC to DC alone. For children with undernutrition, particularly those who were mildly and moderately undernourished, usage of ONS in a nutritional intervention resulted in significantly better growth outcomes when compared to control treatments (usual diet, placebo or DC alone).

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Section: Results For Height Parameters: Change In Height and Height-for-agementioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Quality Of Included Studies and Risk Of Biasmentioning

confidence: 99%

Section: Quality Of Included Studies and Risk Of Biasmentioning

confidence: 99%

See 2 more Smart Citations

Effect of Oral Nutritional Supplementation on Growth in Children with Undernutrition: A Systematic Review and Meta-Analysis

Zhang

Hannon

et al. 2021

Nutrients

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“…Designing public awareness campaigns to improve community awareness regarding URIs is strongly recommended. Furthermore, providing proper nutrition (Ghosh et al, ) and ensuring socioeconomic improvement (Goodman, Loftus, Liu, & Zu, ; Yap, Gilbreath, Garcia, Jareen, & Goodrich, ) are other recommended strategies. Furthermore, strong environmental policies are necessary to combat the negative respiratory health effects of poor air quality on children (Jans, Johannson, & Nilsson, ).…”

Section: Resultsmentioning

confidence: 99%

Prevalence of upper respiratory tract infections and associated factors among children in Turkey

Çınaroğlu

2019

Specialist Pediatric Nursing

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Purpose: Upper respiratory tract infections (URIs) are the most common diseases observed in children aged 0-6 years in Turkey. This study was conducted to investigate URIs in 0-6 year-old children in Turkey. Design and Methods: Data of children aged 0-6 years who were included in the 2014 Turkey Health Survey conducted by the Turkish Statistical Institute were collected from their parents.Results: In total, 1,293 and 1,732 children with and without URIs, respectively, were identified. The weighted point prevalence of URIs was 42.23%. Compared with the uninsured and female children belonging to high-income families, insured male children belonging to low-income families were more likely to develop URIs (p < .001). Moreover, comorbidities such as communicable diseases, anemia and diarrhea, and factors like health services utilization were associated with URIs.Analysis of health services utilization highlights that URIs were reported more among the children who had not visited a hospital than among those who had visited a hospital, with an odds ratio of 1.23. Conclusions:The results of this study provide a deeper understanding of sociodemographic, comorbid, and health services utilization factors associated with URIs.These results provide useful insights for pediatric nursing professionals to improve the quality and efficiency of pediatric respiratory nursing services.Practice Implications: Collaborative networks with other health professionals, parents, and public health policy-makers are essential to decrease the prevalence of URIs in Turkey. These study results provide several insights for health professionals to improve pediatric action plans for ultimately improving child health status. K E Y W O R D S children, prevalence, respiratory care, Turkey, upper respiratory tract infections 1 | WHAT IS CURRENTLY KNOWN? Upper respiratory tract infections (URIs) are the most common diseases among children aged 0-6 years in Turkey. However, there is a lack of knowledge about the factors associated with URIs among children. | WHAT DOES THIS ARTICLE ADD?This study adds value by highlighting the prevalence of URIs that was 42.23% among 0-6 year-old children in Turkey during the year 2014.Moreover, male and insured children belonging to low-income families are more likely to experience URIs and communicable diseases (varicella and mumps), diarrhea, and anemia are the comorbidities strongly associated with URIs.

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The effect of oral nutrition supplements and appetite stimulants on weight status among pediatric cancer patients: A systematic review

et al. 2022

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The objective of this study was to identify the use and impact of oral nutrition supplements (ONSs) and appetite stimulants on weight status among pediatric patients diagnosed with malignancy. We performed a literature search of trials using Medline PubMed, CINAHL, Web of Science Core Collection, Scopus, and Cochrane Database of Systematic Reviews and included all prospective studies except review articles and case-reports/series that assessed ONSs or appetite stimulants among patients (0-20 years old) diagnosed with a pediatric malignancy. Databases were searched through May 17, 2022. There were six trials included with three studies related to ONS and the remaining on appetite stimulants. No studies that compared both ONS and appetite stimulants were found. To assess quality, we used the Risk of Bias in Nonrandomized Studies of Interventions and the Revised Cochrane Risk of Bias Tool for Randomized Trials depending on the study design. The studies all had pediatric patients diagnosed with a variety of malignancy types. All studies demonstrated improvement of weight status in the treatment group across various malignancy types. However, none of the studies addressed nutrition intakes outside of ONS consumption, compliance to ONSs, or frequency of ONS use. Despite the short durations (3-6 months) and significant differences in the timing of intervention initiation (ONS or appetite stimulants), these treatment modalities can improve weight status. Further research is needed to identify the best intervention for improving weight status.

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Effect of oral nutritional supplementation on growth and recurrent upper respiratory tract infections in picky eating children at nutritional risk: a randomized, controlled trial

Cited by 18 publications

References 24 publications

Effect of Oral Nutritional Supplementation on Growth in Children with Undernutrition: A Systematic Review and Meta-Analysis

Effect of Oral Nutritional Supplementation on Growth in Children with Undernutrition: A Systematic Review and Meta-Analysis

Prevalence of upper respiratory tract infections and associated factors among children in Turkey

The effect of oral nutrition supplements and appetite stimulants on weight status among pediatric cancer patients: A systematic review

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