Effect of Osteopathic Cranial Manipulative Medicine on an Aged Rat Model of Alzheimer Disease

Tobey, Hope; Lucas, Tyler; Bledsoe, Douglas; Mykins, Michael; Campbell, Caroline; Berr, Stuart S.; Sasser, Todd A.; Helm, Richard; Brolinson, P. Gunnar; Klein, Bradley G.; Costa, Blaise M.

doi:10.7556/jaoa.2019.121

Cited by 9 publications

(6 citation statements)

References 40 publications

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“…This finding is consistent with a pre-clinical study by Tobey and colleagues who investigated the effect of cOMM on improving the conditions related to AD, such as attenuating amyloid-β levels and reducing levels of activated astrocytes. 57 Aged AD animals received cOMM every day for 7 days, with histological analysis revealing an increase in GFAP expression in the DG subregion, which was also observed in this pilot study. Tobey and colleagues hypothesized that with the increased circulation of fluid as a result of the cOMM treatment, astrocytes could be directly involved in these waste clearance mechanisms.…”

Section: Discussionsupporting

confidence: 80%

Osteopathy in the Cranial Field as a Method to Enhance Brain Injury Recovery: A Preliminary Study

Dickerson

Murphy

Hyppolite

et al. 2022

Neurotrauma Reports

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The clinical burden of traumatic brain injury (TBI) continues to grow worldwide, with patients often developing chronic neurological, behavorial, and cognitive deficits. Treatment and management strategies remain a key challenge, given that they target the symptoms and not the underlying pathological response. To advance pre-clinical research and therapeutic developments, there is a need to study treatment strategies that improve brain injury recovery. Cranial osteopathic manipulative medicine (cOMM) is a non-invasive and non-pharmacological strategy that has been shown to improve quality of life for several medical conditions and injuries, and may be able to treat TBI and reduce subsequent symptoms. In this study, we aimed to evaluate the neurobiological effect of cOMM on the injury response and its potential to alleviate symptoms. We investigated the ability of cOMM to enhance fluid transport by quantifying fluorescent tracer clearance throughout the brain. Further, using an in vivo TBI model, male rats were exposed to a repeated blast overpressure that was followed by cOMM treatment 24 h later. Our findings indicated that cOMM treatment attenuated acute and subacute anxiety-like behaviors. Post-mortem pathological examination in the hippocampus, pre-frontal, and motor cortices indicated improvements in glial pathology in cOMM-treated animals compared to the untreated injury group. Overall, this is the first study to explore cOMM as a treatment option for brain injury, demonstrating its capability to improve TBI outcomes.

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Section: Discussionsupporting

confidence: 80%

Osteopathy in the Cranial Field as a Method to Enhance Brain Injury Recovery: A Preliminary Study

Dickerson

Murphy

Hyppolite

et al. 2022

Neurotrauma Reports

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“…The interest in nontraditional medicine and alternative techniques for symptom relief is not a new interest. Dating back to the 20th century, Abraham Flexner wrote about the addition of osteopathic medicine to scientific education and research [ 48 ]. Flexner’s thoughts about integrating additional medical techniques into education have been influential to modern medical teachings and become part of the curricula and values taught by medical education.…”

Section: Cranial Osteopathymentioning

confidence: 99%

Osteopathic Manipulative Medicine: A Brief Review of the Hands-On Treatment Approaches and Their Therapeutic Uses

et al. 2022

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Osteopathic manipulative medicine (OMM) is an emerging practice in the healthcare field with increasing popularity and evidence-based therapy. Osteopathic manipulative treatments (OMT) include hands-on manipulations of different body structures to increase systemic homeostasis and total patient well-being. Indeed, this new realm of the whole patient-based approach is being taught in osteopathic schools around the country, and the osteopathic principles of a mind-body-spirit-based treatment are being instilled in many new Doctor of Osteopathy (D.O.) students. However, despite their proven therapeutic value, there are still many individuals, both in and outside the medical profession, who are unaware (or misinformed) of the therapeutic uses and potential benefits of OMT. Here, we provide a brief introduction to this osteopathic therapeutic approach, focusing on the hands-on techniques that are regularly implemented in the clinical setting. It is becoming increasingly evident that different OMTs can be implemented to enhance patient recovery, both alone and in conjunction with the targeted therapies used in allopathic regimens. Therefore, it may be beneficial to inform the general medical community and educate the public and those associated with the healthcare field about the benefits of using OMT as a treatment modality. OMT is lower-cost, noninvasive, and highly effective in promoting full-body healing by targeting the nervous, lymphatic, immune, and vascular systems. There is a growing body of literature related to osteopathic research and the possible molecular pathways involved in the healing process, and this burgeoning field of medicine is expected to increase in value in the healthcare field. This brief review article explains the frequently utilized OMT modalities and their recognized therapeutic benefits, which underscore the need to understand the possible molecular mechanisms and circulating biomarkers linked to the systemic benefits of osteopathic medicine.

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“…Observational studies have shown a reduction in symptoms associated with dementia [13] and multiple sclerosis [14]. Studies have also shown that OCMM affects cerebral blood ow [15,16], tissue oxygenation in prefrontal lobes [17], brain cortex electrical activity [18] and reduction in Amyloid beta (Aβ) protein levels [19,20]. How might OCMM produce these effects?…”

Section: Main Textmentioning

confidence: 99%

Cranial Manipulation Modulates Cholinergic Pathway Gene Expression in an Animal Model of Age-related Cognitive Decline

Anandakrishnan

Tobey

Nguyen

et al. 2020

Preprint

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Age dependent dementia is a devastating disorder afflicting the growing older population around the world. Although pharmacological agents improve symptoms of dementia, age related co-morbidities combined with adverse effects often outweigh their clinical benefits. Therefore, non-pharmacological therapies are being investigated as an alternative. Randomized controlled trials and observational studies have shown promising results for cranial manipulation as a treatment for dementia and other nervous system disorders. In this study we examine the effect of osteopathic cranial manipulative medicine (OCMM) on gene expression, in an animal model for age-related cognitive decline (aged rats). We found that OCMM significantly affected the expression of 36 genes in the neuronal pathway (False Discovery Rate (FDR) < 0.004). The top five neuronal genes with the largest fold-change (Slc5a7, Chat, Slc18a3, Adcy5 and Cacna2d2, >2-fold change, FDR<0.004) are part of the cholinergic neurotransmission mechanism, which is known to affect cognitive function. Slc5a7, the highest overexpressed neuronal gene (3-fold change) encodes a sodium and chloride ion-dependent high-affinity transporter that mediates choline uptake for acetylcholine synthesis in cholinergic neurons. This is the pathway enhanced by the clinically used Alzheimer’s disease drug Donepezil, which selectively inhibits acetylcholinesterase, an enzyme that catalyzes endogenous acetylcholine degradation. In addition, 40% of significant differentially expressed (SDE) genes (FDR<0.004), have been previously implicated in neurological disorders. Overall, SDE genes and their role in central nervous system signaling pathways suggest a connection to previously reported OCMM induced behavioral and biochemical changes in rat models of age-dependent dementia. Further investigation in this direction will provide a better understanding of the molecular mechanisms of OCMM and its potential in clinical applications. With clinical validation, OCMM could represent a much needed low-risk adjunct treatment for age-related dementia including Alzheimer’s disease.

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Effect of Osteopathic Cranial Manipulative Medicine on an Aged Rat Model of Alzheimer Disease

Cited by 9 publications

References 40 publications

Osteopathy in the Cranial Field as a Method to Enhance Brain Injury Recovery: A Preliminary Study

Osteopathy in the Cranial Field as a Method to Enhance Brain Injury Recovery: A Preliminary Study

Osteopathic Manipulative Medicine: A Brief Review of the Hands-On Treatment Approaches and Their Therapeutic Uses

Cranial Manipulation Modulates Cholinergic Pathway Gene Expression in an Animal Model of Age-related Cognitive Decline

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