Effect of partial liver resection on tumour growth

Jong, Koert P. de; Slooff, Maarten J. H.; Vries, Elisabeth G.E. de; Brouwers, Mark A. M.; Terpstra, Onno T.

doi:10.1016/s0168-8278(96)80336-9

Cited by 29 publications

(27 citation statements)

References 125 publications

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“…Development and progression of liver cancer and liver metastases is a multifaceted molecular process, which is linked to alterations in some prominent cellular signalling pathways, including RAS/RAF-MAPK pathway, phosphatidylinositol-3 kinase (PI3K)/AKT pathway, WNT/ β-catenin pathway, insulin-like growth factor pathway (IGF), hepatocyte growth factor (HGF)/c-MET pathway and growth factor-regulated angiogenic signaling [16,19,[58][59][60][61] . It has been demonstrated that the cellular and molecular changes following hepatectomy, including surgical stress responses, ischemia reperfusion injury can alter the kinetics of tumor growth and thereby contribute to recurrence [16,[62][63][64] .…”

Section: Regeneration Factors Influencing Tumor Growth and Metastasismentioning

confidence: 99%

“…It has been demonstrated that the cellular and molecular changes following hepatectomy, including surgical stress responses, ischemia reperfusion injury can alter the kinetics of tumor growth and thereby contribute to recurrence [16,[62][63][64] . The factors related to the surgical stress itself represent transient changes, whereas the process of liver regeneration can act as a stronger and more sustained stimulus that promotes the growth of occult tumors and neoplastic development.…”

Section: Regeneration Factors Influencing Tumor Growth and Metastasismentioning

confidence: 99%

“…The factors related to the surgical stress itself represent transient changes, whereas the process of liver regeneration can act as a stronger and more sustained stimulus that promotes the growth of occult tumors and neoplastic development. Liver regeneration after surgery provides a microenvironment with many growth factors and cytokines that are favorable for tumorgenesis and tumor propagation through cell activation, proliferation, migration and angiogenesis [16,19,[24][25][26][27] . The majority of studies in HCC indicate that factors linked to tumor invasiveness and vascular involvement are the most important [20] .…”

Section: Regeneration Factors Influencing Tumor Growth and Metastasismentioning

confidence: 99%

“…Colorectal cancer (CRC) is the third most common cancer [1] and the fourth leading cause of cancer deaths worldwide [14,15] . javascript:newshowcontent ("active", "references"); The liver is the most frequent and often unique site of metastasis (colorectal liver metastases -CLM) and are present at diagnosis of CRC in about 30% of patients (synchronous) and in about 40% of patients after aggressive surgery on the primary tumor (metachronous) [16,17] . Modern surgical techniques and chemotherapy can improve the five-year survival rate for selected patients with CLM, but intrahepatic recurrence after liver resection occurs in 40%-60% of patients, usually within 12-18 mo postoperatively [18,19] .…”

Section: Introductionmentioning

confidence: 99%

“…Accumulating clinical and experimental studies have suggested that liver regeneration following surgical resection may activate occult micrometastases, facilitate tumor growth and thereby contribute to tumor recurrence [16,[24][25][26][27] . Similarly, an enhanced tumor growth rate has been reported following portal vein embolization when performed as a preparation to liver resection [28] .…”

Section: Introductionmentioning

confidence: 99%

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Effect of liver regeneration on malignant hepatic tumors

Shi

Line

2014

WJG

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Liver regeneration after major surgery may activate occult micrometastases and facilitate tumor growth, leading to liver tumor recurrence. Molecular changes during liver regeneration can provide a microenvironment that stimulates intrahepatic tumor propagation through alterations in cellular signaling pathways, where activation and proliferation of mature hepatocytes, hepatic progenitor cells, non-parenchymal liver cells might favor both liver regeneration and tumor growth. This review highlights recent advances of tumor growth and development in the regenerating liver, possible mechanisms and clinical implications. Key words: Hepatocellular carcinoma; Colorectal cancer; Recurrence; Liver regeneration; Hepatic progenitor cell; Epithelial to mesenchymal transition Core tip: The liver has a unique capacity for regeneration after cellular damage or partial removal of tissue, and modern liver surgery relies on this property. Liver regeneration is a complex process involving a large array of growth factors, cytokines and cells to restore hepatic mass and function. Experimental and clinical data indicate that the regeneration signals facilitate the growth of both primary and secondary liver tumors and can alter their malignant potential. This is an important mechanism underlying recurrence after liver surgery. New therapeutic strategies founded on better insight into the relationship between liver regeneration and tumor biology are needed.Shi JH, Line PD. Effect of liver regeneration on malignant hepatic tumors.

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Section: Regeneration Factors Influencing Tumor Growth and Metastasismentioning

confidence: 99%

Section: Regeneration Factors Influencing Tumor Growth and Metastasismentioning

confidence: 99%

Section: Regeneration Factors Influencing Tumor Growth and Metastasismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effect of liver regeneration on malignant hepatic tumors

Shi

Line

2014

WJG

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Interstitial laser thermotherapy in the treatment of colorectal liver metastases

Muralidharan

Christophi

2001

J. Surg. Oncol.

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Metastatic liver disease is the commonest cause of death in patients with colorectal cancer. A small proportion of these patients (10%) may be treated by surgical resection with five year survival approaching 35-40%. Alternative treatment modalities for localised hepatic disease include in situ ablative techniques that have the advantages of percutaneous application and minimal morbidity. These include Interstitial Laser Thermotherapy (ILT), Radio Frequency Ablation, Percutaneous Microwave therapy, and Focussed Ultrasound Therapy. This article focuses specifically on the development and utilisation of ILT in the treatment of colorectal liver metastases. It provides a review of the pathophysiological factors involved, present status of clinical studies, and future directions. ILT is a safe technique for the treatment of colorectal liver metastases. It may be delivered by minimally invasive techniques to lesions considered unresectable by present criteria. Limitations include the extent and completeness of tumour necrosis achieved as well as imaging techniques. Clinical problems include a lack of controlled studies. Assessment of long-term survival in prospective randomised trials is needed to assess the efficacy of this procedure.

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Clinical relevance of transforming growth factor α, epidermal growth factor receptor, p53, and Ki67 in colorectal liver metastases and corresponding primary tumors

et al. 1998

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To determine whether the expression of transforming growth factor ␣ (TGF-␣), its receptor (epidermal growth factor receptor [EGFr]), p53 nuclear protein, and proliferation influences prognosis of patients with liver metastases, a study was performed in 45 liver metastases and 33 corresponding primary colorectal carcinomas in patients referred for liver surgery. The expression of TGF-␣, EGFr, p53 nuclear protein, and proliferation rate was correlated with clinicopathological characteristics and survival after partial liver resection. In liver metastases, TGF-␣ expression was low in 42%, intermediate in 35%, and high in 23%. TGF-␣ expression was higher in liver metastases derived from lymph node-positive primary carcinomas, in synchronous and in irresectable liver metastases compared with those derived from lymph node-negative primary carcinomas, metachronous, and resectable liver metastases. Nuclear p53 expression was found in 83% of primary tumors and 71% of liver metastases. p53 expression did not correlate with the various clinicopathological characteristics. Ki67 expression was not associated with clinicopathological characteristics in primary and metastatic tumors. In the 38 patients in whom a partial liver resection was performed, median survival was 25 months in patients with a higher TGF-␣ expression in the metastasis than in the primary tumor and 60 months in patients with comparable or lower TGF-␣ expression in the metastasis than in the primary tumor (P ‫؍‬ .036). Median survival after liver resection was 21 months in patients with p53-negative liver metastases and 58 months in patients with p53-positive metastases (P ‫؍‬ .043). By multivariate analysis, p53 and EGFr expression on liver metastases were the best predictors of diseasefree survival after partial liver resection, with relative risks of 2.38 and 3.33, respectively. In patients with colorectal liver metastases, referred for liver surgery, a higher TGF-␣ expression is associated with unfavorable tumor characteristics, whereas p53 and absence of EGFr expression is associated with a better survival after partial liver resection. (HEPATOLOGY 1998;28:971-979.)Colorectal carcinoma is the second-leading cause of cancer deaths in the Western community. Of all colorectal cancer patients, about 50% will die within 5 years after diagnosis. 1 At the time of initial diagnosis, 15% to 25% of patients present with synchronous liver metastases. 1 It is estimated that overall, only 5% of patients who develop liver metastases of colorectal carcinomas are amenable to partial liver resection. 2 Despite intentionally curative liver resections, only 20% to 30% of these patients have a disease-free 5-year survival. [3][4][5] Furthermore, in patients with recurrences after liver resection, these recurrences often appear early after liver surgery, with the liver being a frequent site of initial failure. 5,6 In the animal model, tumor growth can be influenced by growth factors produced by the tumor cells and by growth factors generated by the organ that harbors the m...

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Effect of partial liver resection on tumour growth

Cited by 29 publications

References 125 publications

Effect of liver regeneration on malignant hepatic tumors

Effect of liver regeneration on malignant hepatic tumors

Interstitial laser thermotherapy in the treatment of colorectal liver metastases

Clinical relevance of transforming growth factor α, epidermal growth factor receptor, p53, and Ki67 in colorectal liver metastases and corresponding primary tumors

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