Effect of Periodate-Induced Cross-linking on Dual Anticancer Drug Release from Poly(2-isopropyl-2-oxazoline)/Tannic Acid-Based Layer-by-Layer Microparticles
Esma Ugur,
Gökçe Tidim,
Dilara Gundogdu
et al.
Abstract:This study reports, first, on the preparation and cross-linking
of multilayers composed of poly(2-isopropyl-2-oxazoline-
co
-ethyleneimine) (PiPOX-PEI) and tannic acid (TA). PiPOX was synthesized
by cationic ring-opening polymerization (CROP) and partially hydrolyzed,
yielding a random copolymer PiPOX-PEI. It was then coassembled at
the surface with TA using the layer-by-layer (LbL) technique. Multilayers
were exposed to NaIO
4
solution to induce covalent bond
form… Show more
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