Effect of pH on the elimination of the labile fraction of glycosylated hemoglobin.

Bannon, Pierre

doi:10.1093/clinchem/28.10.2183a

Cited by 69 publications

(23 citation statements)

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“…72091 and 72111 respectively) from Qualigens Diagnostics, Mumbai, India. Glycosylated haemoglobin (Bannon 1982), plasma thiobarbituric acid reactive substances (Yagi 1987) and plasma lipid hydroperoxides (HP) (Jiang et al 1992) were estimated.…”

Section: Methodsmentioning

confidence: 99%

Antihyperglycaemic and Antioxidant Effect of Rutin, a Polyphenolic Flavonoid, in Streptozotocin‐Induced Diabetic Wistar Rats

Kamalakkannan

Prince

2006

Basic Clin Pharma Tox

436

250

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Flavonoids are non-nutritive dietary components that are widely distributed in plants. The present study investigated the antihyperglycaemic and antioxidant effect of rutin, a polyphenolic flavonoid in normal and streptozotocininduced diabetic Wistar rats. Diabetes as induced in rats by an intraperitoneal injection of streptozotocin. Rutin was orally administered to normal and diabetic rats for a period of 45 days. Fasting plasma glucose, glycosylated haemoglobin, thiobarbituric acid reactive substances and lipid hydroperoxides were significantly (PϽ0.05) increased, whereas insulin, Cpeptide, total haemoglobin, protein levels, non-enzymic antioxidants (glutathione, vitamin C, vitamin E and ceruloplasmin) were decreased significantly (PϽ0.05) in diabetic rats. Oral administration of rutin to diabetic rats significantly (PϽ0.05) decreased fasting plasma glucose, glycosylated haemoglobin and increased insulin, C-peptide, haemoglobin and protein levels. Administration of rutin also decreased thiobarbituric acid reactive substances and lipid hydroperoxides and increased the non-enzymic antioxidants significantly (PϽ0.05). Treatment of normal rats with rutin did not significantly (PϽ0.05) alter any of the parameters studied. These results show that rutin exhibits antihyperglycaemic and antioxidant activity in streptozotocin-induced diabetic rats.

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Section: Methodsmentioning

confidence: 99%

Antihyperglycaemic and Antioxidant Effect of Rutin, a Polyphenolic Flavonoid, in Streptozotocin‐Induced Diabetic Wistar Rats

Kamalakkannan

Prince

2006

Basic Clin Pharma Tox

436

250

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“…Haemoglobin was estimated using the cyanmethaemoglobin method described by Drabkin & Austin (1932). Glycosylated haemoglobin was estimated according to the method of Sudhakar Nayak & Pattabiraman (1981) with modifications according to Bannon (1982). Thiobarbituric acid reactive substances were measured by the method of Fraga et al (1988).…”

Section: Methodsmentioning

confidence: 99%

Effect of Tetrahydrocurcumin on Lipid Peroxidation and Lipids in Streptozotocin‐Nicotinamide‐Induced Diabetic Rats

Murugan

Pari

2006

Basic Clin Pharma Tox

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Hyperlipidaemia is an associated complication of diabetes mellitus. We recently reported that tetrahydrocurcumin lowered the blood glucose in diabetic rats. In the present study, we have investigated the effect of tetrahydrocurcumin, one of the active metabolites of curcumin on lipid profile and lipid peroxidation in streptozotocin-nicotinamide-induced diabetic rats. Tetrahydrocurcumin 80 mg/kg body weight was administered orally to diabetic rats for 45 days, resulted a significant reduction in blood glucose and significant increase in plasma insulin in diabetic rats, which proved its antidiabetic effect. Tetrahydrocurcumin also caused a significant reduction in lipid peroxidation (thiobarbituric acid reactive substances and hydroperoxides) and lipids (cholesterol, triglycerides, free fatty acids and phospholipids) in serum and tissues, suggesting its role in protection against lipid peroxidation and its antihyperlipidemic effect. Tetrahydrocurcumin showed a better effect when compared with curcumin. Results of the present study indicate that tetrahydrocurcumin showed antihyperlipidaemic effect in addtion to its antidiabetic effect in type 2 diabetic rats.

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“…Blood glucose was estimated by the o-toluidine method [15] Haemoglobin was estimated by the cyanmethaemoglobin method [16]. Glycosylated haemoglobin was estimated by the method of Sudhakar Nayak and Pattabiraman [17] with modification according to Bannon [18]. Plasma insulin was estimated by ELISA kit (Boehringer-Mannheim).…”

Section: Methodsmentioning

confidence: 99%

Antidiabetic effect of diasulin, a herbal drug, on blood glucose, plasma insulin and hepatic enzymes of glucose metabolism in hyperglycaemic rats

Pari

Saravanan

2004

Diabetes Obesity Metabolism

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Effect of pH on the elimination of the labile fraction of glycosylated hemoglobin.

Cited by 69 publications

References 0 publications

Antihyperglycaemic and Antioxidant Effect of Rutin, a Polyphenolic Flavonoid, in Streptozotocin‐Induced Diabetic Wistar Rats

Antihyperglycaemic and Antioxidant Effect of Rutin, a Polyphenolic Flavonoid, in Streptozotocin‐Induced Diabetic Wistar Rats

Effect of Tetrahydrocurcumin on Lipid Peroxidation and Lipids in Streptozotocin‐Nicotinamide‐Induced Diabetic Rats

Antidiabetic effect of diasulin, a herbal drug, on blood glucose, plasma insulin and hepatic enzymes of glucose metabolism in hyperglycaemic rats

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