Effect of Physical Activity/Exercise on Oxidative Stress and Inflammation in Muscle and Vascular Aging

Assar, Mariam El; Álvarez‐Bustos, Alejandro; Sosa, Patricia; Angulo, Javier; Rodríguez‐Mañas, Leocadio

doi:10.3390/ijms23158713

Cited by 133 publications

(69 citation statements)

References 261 publications

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“…Inflammation plays a pivotal role in hypertension, as a large number of studies have already demonstrated that systemic inflammation levels of patients with hypertension are elevated, which are closely associated with arterial stiffness ( 4 ). Investigators also found that inhibition of inflammation can alleviate hypertension in animal models ( 5 , 6 ).…”

Section: Introductionmentioning

confidence: 99%

The dietary inflammatory index and its association with the prevalence of hypertension: A cross-sectional study

et al. 2023

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AimsWe aim to investigate the association of the Dietary Inflammatory Index (DII) with the prevalence of hypertension in a large multiracial population in the United States.MethodsParticipants from the National Health and Nutrition Examination Survey (NHANES) (1999–2018) were included in this cross-sectional study. Dietary information was obtained and used to calculate DII. Blood pressures of participants were measured by experienced examiners. The NHANES used the method of “stratified multistage probability sampling,” and this study is a weight analysis following the NHANES analytic guidance. Weight logistic regression analysis was adopted to investigate the association of hypertension with DII. Least Absolute Shrinkage and Selection Operator (LASSO) regression was carried out to screen the most important dietary factors associated with the risk of hypertension. Moreover, a nomogram model based on key dietary factors was established; the receiver operating characteristic (ROC) curve was used to evaluate the diagnostic power of the nomogram model for screening hypertension risk.ResultsA total of 45,023 participants were included in this study, representing 191 million residents in the United States. Participants with hypertension had an elevated DII compared with those without hypertension. Weight logistic regression showed that an increment of DII was strongly associated with hypertension after adjusting for confounding factors. The nomogram model, based on key dietary factors screened by LASSO regression, showed a favorable discriminatory power with an area under the curve (AUC) of 78.5% (95% CI: 78.5%–79.3%). Results of the sensitivity analysis excluding participants who received any drug treatment were consistent with those in the main analysis.ConclusionAn increment of DII is associated with the risk of hypertension. For better prevention and treatment of hypertension, more attention should be paid to controlling dietary inflammation.

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Section: Introductionmentioning

confidence: 99%

The dietary inflammatory index and its association with the prevalence of hypertension: A cross-sectional study

et al. 2023

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“…Two components are mainly involved in the RBE in our study: (i) the first bout of strength exercise and (ii) the strength training. Regular physical training promotes anti-inflammatory and antioxidant responses [ 64 , 65 ], which additionally contribute to the RBE.…”

Section: Discussionmentioning

confidence: 99%

Fish Oil Supplementation Improves the Repeated-Bout Effect and Redox Balance in 20–30-Year-Old Men Submitted to Strength Training

et al. 2023

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Herein, we investigated the effect of fish oil supplementation combined with a strength-training protocol, for 6 weeks, on muscle damage induced by a single bout of strength exercise in untrained young men. Sixteen men were divided into two groups, supplemented or not with fish oil, and they were evaluated at the pre-training period and post-training period. We investigated changes before and 0, 24, and 48 h after a single hypertrophic exercise session. Creatine kinase (CK) and lactate dehydrogenase (LDH) activities, plasma interleukin-6 (IL-6) and C-reactive protein (CRP) levels, and the redox imbalance were increased in response to the single-bout session of hypertrophic exercises at baseline (pre-training period) and decreased during the post-training period in the control group due to the repeated-bout effect (RBE). The fish oil supplementation exacerbated this reduction and improved the redox state. In summary, our findings demonstrate that, in untrained young men submitted to a strength-training protocol, fish oil supplementation is ideal for alleviating the muscle injury, inflammation, and redox imbalance induced by a single session of intense strength exercises, highlighting this supplementation as a beneficial strategy for young men that intend to engage in strength-training programs.

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“…Skeletal muscle fibrosis impairs muscle function and disrupts muscle regeneration [ 38 ]. Oxidative stress and inflammation act in a feedback loop, contributing to these pathologies [ 39 ].…”

Section: Aging Factors In Skeletal Muscle ( When You Are Ol...mentioning

confidence: 99%

Inflammaging: Implications in Sarcopenia

Antuña

Cachán-Vega

Bermejo-Millo

et al. 2022

IJMS

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In a world in which life expectancy is increasing, understanding and promoting healthy aging becomes a contemporary demand. In the elderly, a sterile, chronic and low-grade systemic inflammation known as “inflammaging” is linked with many age-associated diseases. Considering sarcopenia as a loss of strength and mass of skeletal muscle related to aging, correlations between these two terms have been proposed. Better knowledge of the immune system players in skeletal muscle would help to elucidate their implications in sarcopenia. Characterizing the activators of damage sensors and the downstream effectors explains the inference with skeletal muscle performance. Sarcopenia has also been linked to chronic diseases such as diabetes, metabolic syndrome and obesity. Implications of inflammatory signals from these diseases negatively affect skeletal muscle. Autophagic mechanisms are closely related with the inflammasome, as autophagy eliminates stress signaling sent by damage organelles, but also acts with an immunomodulatory function affecting immune cells and cytokine release. The use of melatonin, an antioxidant, ROS scavenger and immune and autophagy modulator, or senotherapeutic compounds targeting senescent cells could represent strategies to counteract inflammation. This review aims to present the many factors regulating skeletal muscle inflammaging and their major implications in order to understand the molecular mechanisms involved in sarcopenia.

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Effect of Physical Activity/Exercise on Oxidative Stress and Inflammation in Muscle and Vascular Aging

Cited by 133 publications

References 261 publications

The dietary inflammatory index and its association with the prevalence of hypertension: A cross-sectional study

The dietary inflammatory index and its association with the prevalence of hypertension: A cross-sectional study

Fish Oil Supplementation Improves the Repeated-Bout Effect and Redox Balance in 20–30-Year-Old Men Submitted to Strength Training

Inflammaging: Implications in Sarcopenia

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