Effect of physical restraint on glucose tolerance in cynomolgus monkeys

Shirasaki, Yasufumi; Yoshioka, Naoya; Kanazawa, K; Maekawa, Taira; Horikawa, Tadahiro; Hayashi, Toshiaki

doi:10.1111/jmp.12039

Cited by 15 publications

(13 citation statements)

References 8 publications

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“…From another perspective, carbohydrates and saturated fatty acids have been reported to be preferred by people with chronic stress, resulting in weight gain 4 . It has been reported that the concentration of cortisol in Cynomolgus monkey is increased by restraint stress 5 . On the other hand, exercise can enhance resistance to stress and suppressed anxiety.…”

Section: Introductionmentioning

confidence: 99%

Effects of voluntary exercise on apoptosis and cortisol after chronic restraint stress in mice

Seo

Park

Choi

et al. 2016

Journal of Exercise Nutrition &Amp; Biochemistry

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[Purpose]To determine whether voluntary exercise (wheel running) has the potential of relieving stress. [Methods]In this study, restraint stress with or without voluntary wheel running was performed for mice housed in individual cages. A total of 21 ICR male mice were assigned into control (CON), restraint stress with voluntary exercise (RSVE), or restraint stress (RS) without voluntary exercise groups (n = 7 each). [Results]No significant difference in body weight increase was found among the three groups, although CON and RS groups had a tendency of having smaller body weight increase compared to the RSVE group. No significant difference in the expression level of liver heat shock protein 70, Bcl-2, or p53 was found among the three groups. However, caspase-3 protein level in RS group was significantly higher than that in the other two groups. Blood cortisol concentration in RS was higher (p < 0.05) than that in RSVE or CON group. It was the lowest (p < 0.05) in the RSVE group. [Conclusion]Our findings suggest that apoptosis caused by chronic restraint stress might be suppressed by voluntary exercise in mice.

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Section: Introductionmentioning

confidence: 99%

Effects of voluntary exercise on apoptosis and cortisol after chronic restraint stress in mice

Seo

Park

Choi

et al. 2016

Journal of Exercise Nutrition &Amp; Biochemistry

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“…It has previously been demonstrated in two species of macaques that ketamine might invalidate oral carbohydrate tolerance tests by delaying gastric emptying. 32 Given that physical restraint has been shown to affect the response to glucose challenge, 33 these collective findings suggest that definitive evaluation of reproducibility of OGTT response in nonhuman primates may warrant further method development.…”

Section: Discussionmentioning

confidence: 99%

Characterization of glucose‐stimulated insulin release protocols in african green monkeys (Chlorocebus aethiops)

Liddie¹,

Okamoto

Gromada

et al. 2018

J of Medical Primatology

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Background Management of diabetes remains a major health and economic challenge, demanding test systems in which to develop new therapies. These studies assessed different methodologies for determining glucose tolerance in green monkeys. Methods Twenty‐eight African green monkeys between 4 and 24 years old underwent single or repeat intravenous glucose tolerance testing ( IVGTT ), oral glucose tolerance testing ( OGTT ), and/or graded glucose infusion testing. Results Geriatric monkeys exhibited glucose intolerance with impaired glucose‐stimulated insulin secretion following IVGTT . Repeat IVGTT and OGTT assessments were inconsistent. Monkeys with low glucose‐stimulated insulin secretion after graded glucose infusion exhibited elevated blood glucose levels. Conclusion IVGTT and graded glucose infusion protocols revealed differences in glucose tolerance among green monkeys at single time points, including age‐dependent differences suggestive of shifts in pancreatic beta‐cell functional capacity, but care should be applied to study design and the interpretation of data in the setting of longitudinal studies.

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“…Conducting the very best science depends on keeping abreast of the latest knowledge and techniques, not just in research methods and scientific procedures, but also in NHP behaviour, management and welfare, as increasingly studies demonstrate a link between good animal welfare and quality of science (Graham et al, 2011;Guth et al, 2009;Reinhardt, 2004;Schnell and Gerber, 1997;Shirasaki et al, 2013). Researchers, veterinarians and animal care staff should therefore supplement their initial training with continuing learning and professional development, part of which can be provided by resources online.…”

Section: Discussionmentioning

confidence: 99%

Online resources for improving the care and use of non-human primates in research

Prescott

2016

Primate Biol.

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Abstract. Published literature and scientific events provide opportunities to expand knowledge and develop skills in the care and use of non-human primates (NHPs) in research. Increasingly, these traditional routes of information exchange are being complemented by dedicated online resources aimed at sharing best practice in NHP care and use, and enhancing the training and professional development of laboratory staff working with NHPs. This article outlines some key online resources from the UK's National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) and other organisations with an interest in NHP research, and the ways in which the resources can be integrated into staff training and research practices to enhance animal welfare, quality of science and application of the 3Rs.

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Effect of physical restraint on glucose tolerance in cynomolgus monkeys

Abstract: The responses to a glucose challenge are altered by different restraint procedures.

Cited by 15 publications

References 8 publications

Effects of voluntary exercise on apoptosis and cortisol after chronic restraint stress in mice

Effects of voluntary exercise on apoptosis and cortisol after chronic restraint stress in mice

Characterization of glucose‐stimulated insulin release protocols in african green monkeys (Chlorocebus aethiops)

Online resources for improving the care and use of non-human primates in research

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