Effect of phytic acid etchant on the structural stability of demineralized dentine and dentine bonding

Kong, Kalyan; Islam, Md. Sofiqul; Nassar, Mohannad; Hiraishi, Noriko; Otsuki, Masayuki; Yiu, Cynthia Kar Yung; Tagami, Junji

doi:10.1016/j.jmbbm.2015.03.027

Cited by 22 publications

(13 citation statements)

References 32 publications

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“…Apart from the solvent used for PA solubilisation, several other factors have led to inconsistent outcomes in the literature. The demineralization process, the use of 10-37% phosphoric acid for various times that ranged from 30 seconds up to 5-10 h [26, 45, 71, 72], treatment buffer media (PBS, HEPES, and water), treatment pH 7 [71] pH 7.2 [26, 45], and pH 7.4 [27] are also important parameters that can affect the structural stability of the cross-linked collagen material. The cross-linking efficacy of GSE depends on its molecular size and pyrogallol content (galloylation) [43].…”

Section: Polyphenols In Biomedical Applicationsmentioning

confidence: 99%

“…There is a diverse range of monomeric and oligomeric PA that are extracted from different plants using different extraction methods, which accentuates the importance of standardizing PA used for dentin collagen cross-linking. In addition to the GSE, CSE and epigallocatechin-3-gallate (EGCG), phytic acid has been recently evaluated for the enhancement of the structural stability of the dentine collagen network [71]. The hydrogen bonding formation between the phytic acid, hydroxyl groups and the amino acid side chains amino groups of the collagen molecules was suggested as the responsible mechanism for the cross-linking process [45, 65, 71].…”

Section: Polyphenols In Biomedical Applicationsmentioning

confidence: 99%

“…In addition to the GSE, CSE and epigallocatechin-3-gallate (EGCG), phytic acid has been recently evaluated for the enhancement of the structural stability of the dentine collagen network [71]. The hydrogen bonding formation between the phytic acid, hydroxyl groups and the amino acid side chains amino groups of the collagen molecules was suggested as the responsible mechanism for the cross-linking process [45, 65, 71]. While in the case of phytic acid, the cross-linking efficacy is pH dependent, whereas at low pH an electrostatic interaction occurs between the protein and the phytic acid [74].…”

Section: Polyphenols In Biomedical Applicationsmentioning

confidence: 99%

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Polyphenol uses in biomaterials engineering

et al. 2018

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Polyphenols are micronutrients obtained from diet that have been suggested to play an important role in health. The health benefits of polyphenols and their protective effects in food systems as antioxidant compounds are well known and have been extensively investigated. However, their functional roles as a "processing cofactor" in tissue engineering applications are less widely known. This review focuses on the functionality of polyphenols and their application in biomaterials. Polyphenols have been used to stabilize collagen and to improve its resistance to degradation in biological systems. Therefore, they have been proposed to improve the performance of biomedical devices used in cardiovascular systems by improving the mechanical properties of grafted heart valves, enhancing microcirculation through the relaxation of the arterial walls and improving the capillary blood flow and pressure resistance. Polyphenols have been found to stimulate bone formation, mineralization, as well as the proliferation, differentiation, and the survival of osteoblasts. These effects are brought about by the stimulatory effect of polyphenols on osteoblast cells and their protective effect against oxidative stress and inflammatory cytokines. In addition, polyphenols inhibit the differentiation of the osteoclast cells. Collectively, these actions lead to promote bone formation and to reduce bone resorption, respectively. Moreover, polyphenols can increase the cross-linking of dentine and hence its mechanical stability. Overall, polyphenols provide interesting properties that will stimulate further research in the bioengineering field.

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Section: Polyphenols In Biomedical Applicationsmentioning

confidence: 99%

Section: Polyphenols In Biomedical Applicationsmentioning

confidence: 99%

Section: Polyphenols In Biomedical Applicationsmentioning

confidence: 99%

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Polyphenol uses in biomaterials engineering

et al. 2018

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“…The effect of IP6 on dentinal collagen was later confirmed in a study that reported improved ultimate tensile strength of demineralized dentine upon treatment with IP6, which was comparable to results obtained with glutaraldehyde, a gold standard crosslinking agent used in dental research. Dentinal collagen exposed by IP6 was also less susceptible to collapse by airdrying and to collagenase degradation when compared with the fragile network of collagen attained by the use of phosphoric acid (Kong et al, 2015;Kong et al, 2017).…”

Section: Etching Agentmentioning

confidence: 96%

Phytic Acid: Properties and Potential Applications in Dentistry

Nassar

Maki

et al. 2021

Front. Mater.

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Inositol hexaphosphate (IP6) is the most abundant inositol phosphate in nature and an essential molecule for different biological functions. IP6 has a unique structure granting it distinctive properties; a high negative charge density provides IP6 with an immense chelating ability and valuable antioxidant properties. IP6 is also simple and cost-effective to produce. These features have attracted researchers and entrepreneurs to further study IP6 for a wide variety of applications in areas such as pharmaceutical, food and chemical industries, medicine, pharmacy, nutrition, and dentistry. The interest in IP6 in the dental field unfolded many decades ago following identification of a cariostatic ability and a positive impact on reducing enamel dissolution. Subsequently, IP6’s anti-plaque, anti-calculus and cement-forming properties have been investigated. Despite encouraging findings, there was a phase of decreased attention to IP6 which slowed down research progress. However, the potential use of IP6 has recently been revisited through several publications that provided deeper understanding into its mechanisms of action in the aforementioned applications. Studies have also explored new applications in endodontics, adhesive, preventive and regenerative dentistry, and IP6’s role in improving the characteristics and performance of dental materials. Evidence of the merits of IP6 in dentistry is now substantial, and this narrative review presents and discusses the different applications proposed in the literature and gives insights of future use of IP6 in the fields of orthodontics, implant and pediatric dentistry.

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“…On the basis of these advantages, 1% IP6 was proposed as an alternative chelating agent in a recent report (11). Variables such as its effect on microhardness (16), removal ability of intracanal medication (17), effect on dentine bond (18), chelating efficacy (19), calcium loss from root dentine (20), effect on dental pulp stem cells (21), effect on calcium silicate based cements (22), antimicrobial effect (23) and role in regenerative endodontics (24) have been reported previously.…”

Section: Preparation Of 1% Ip6mentioning

confidence: 99%

Erosive potential of 1% Phytic Acid on radicular dentine at different time intervals

et al. 2019

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The objective of this in-vitro study was to compare the erosive potential and smear layer removal ability of 1% Phytic acid (IP6) and 17% Ethylenediaminetetaacetic acid (EDTA). Methods: Canal preparation of 225 single rooted extracted human teeth was performed with Protaper NiTi rotary instruments. Teeth were divided into three groups according to the final irrigation protocol. Group 1: Saline irrigation (n=75), Group 2: 17% EDTA (n=75), Group 3: 1% Phytic Acid (n=75). Roots were splitted and observed under Scanning Electron Microscope (SEM) for erosion and smear layer removal. Mean differences between the groups for smear layer removal and erosion were assessed using the Kruskal Wallis and Mann Whitney U test. (P≤0.05) Friedman and Willcoxon Signed Rank tests were used to make comparisons within the groups. Results: Group 3 was significantly less erosive than Group 2 at all root portions (P<0.001). With regards to smear layer removal, group 2 (EDTA) removed more smear layer compared to group 3 (Phytic acid) at all root portions (P<0.001). Both 17% EDTA and 1% IP6 removed significantly less smear layer in the apical root portion. Intra group comparisons revealed no significant differences at any root level. There was a time dependent increase in erosion and smear layer removal in Group 2, with severe erosion at 5 minutes time interval. In Group 3, however, there was moderate erosion and smear removal at 3 and 5 minutes interval. Conclusion: IP6 at the concentration of 1% and pH 3 was less erosive than 17% EDTA. It exhibited moderate smear layer removal ability.

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Effect of phytic acid etchant on the structural stability of demineralized dentine and dentine bonding

Cited by 22 publications

References 32 publications

Polyphenol uses in biomaterials engineering

Polyphenol uses in biomaterials engineering

Phytic Acid: Properties and Potential Applications in Dentistry

Erosive potential of 1% Phytic Acid on radicular dentine at different time intervals

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