Effect of phytic acid, ethylenediaminetetraacetic acid, and chitosan solutions on microhardness of the human radicular dentin

Nikhil, Vineeta; Jaiswal, Shikha; Bansal, Parul; Arora, Rohit; Raj, Shalya; Malhotra, Pulkit

doi:10.4103/0972-0707.178705

Cited by 32 publications

(47 citation statements)

References 24 publications

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“…The results are in accordance with Nikhil et al (33) who reported that 0.2% chitosan caused less reduction in dentin microhardness than 17%EDTA. On the other hand, the results are in disagreement with those of Pimenta et al (32) who found that 0.2% chitosan equally effective to 15% EDTA and 10% citric acid in microhardness reduction.…”

Section: Discussionsupporting

confidence: 92%

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Impact of Chitosan as Chelating Agent on Microhardness and Mineral Content of Intraradicular Dentin

Bastawy

Ezzat²

2016

ADJ-for Girls

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Aim: This study was designed to evaluate the effects of 0.2% chitosan, 2% chitosan and 17% EDTA chelating agents on the microhardness and mineral content of human root canal dentin. Materials and Methods: Sixty extracted single-rooted human teeth were longitudinally sectioned into 120 segments. The specimens were randomly divided into four groups according to the chelating agent used; G1: 0.2% chitosan, G2: 2% chitosan, G3: 17% EDTA and G4: saline (control group). Dentin microhardness was measured in a total of 80 specimens using Vickers diamond indenter with 300 g load and a dwell time of 20 s. A total volume of 5 mL of each solution was used for 3min and then specimens finally flushed with 10 mL distilled water. In a total of 40 specimens, the level of three elements (calcium, phosphorus and magnesium) in each specimen was analyzed using inductively coupled plasma atomic emission spectrometry (ICP-AES). Results: All tested chelating agents significantly decreased the microhardness of root canal dentin (P ≤ 0.05) and reduced the mineral content of dentin. Chitosan 2% and 17% EDTA had the statistically significant highest mean percentage reduction in microhardness compared to the control group (P ≤ 0.05) and showed the maximum loss of Ca ions from root canal dentin. Chitosan 0.2% showed less reduction in dentin microhardness and chelated Ca ions from root dentin. Conclusions: Chitosan 0.2% solution is equally effective to 17% EDTA in removing Ca ions from root canal dentin without much altering its microhardness. Accordingly, the natural product of 0.2% chitosan attracts its use as dentin chelating agent.

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Section: Discussionsupporting

confidence: 92%

“…Pimenta et al (32) revealed that 0.2% chitosan reduced root dentin microhardness similarly to 15% EDTA and 10% citric acid solutions. Moreover, Nikhil et al (33) reported that 0.2% chitosan caused less reduction in dentin microhardness than EDTA.…”

Section: Cruz-filho Et Almentioning

confidence: 99%

Impact of Chitosan as Chelating Agent on Microhardness and Mineral Content of Intraradicular Dentin

Bastawy

Ezzat²

2016

ADJ-for Girls

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“…In the present study, the coronal segments had significantly lower dentin microhardness in comparison with the middle and the apical segments in all groups. This finding agrees with several studies (14,24,36). This may be attributed to the histological pattern of the root canal dentin and relative nature of dentin in the apical region as Carrigan et al (21) showed that tubule density decreased from cervical to apical dentin and Pashley et al (22) reported that there was an inverse correlation between dentine microhardness and tubular density.…”

Section: Discussionsupporting

confidence: 89%

“…Finally, it is recommended that chelators as EDTA can be used in low concentrations (3,29) or shorter chelating time (3,26) and NaOCl solutions can be used in low concentrations (3,28). A final flush of NaOCL after EDTA must be considered (3,17,33) which could be replaced by CHX (2,3) or other new irrigant solutions (3,31,36,38,39). As well as remineralizing agent may be used before bonding procedures for promoting remineralization and improving the microhardness of eroded root dentin (19,40).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Microhardness of Root Canal Dentin After Different Irrigation Protocols (In Vitro Study)

Massoud

Moussa

Hanafy

et al. 2017

Alexandria Dental Journal

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INTRODUCTION: Different irrigations solutions may cause alteration in the physicochemical properties of dentin structure thereby affecting the microhardness of root canal dentin. OBJECTIVES: to evaluate the effect of different irrigation protocols on microhardness of human root canal dentin. MATERIALS AND METHODS: Forty extracted single rooted lower premolars were used. All teeth were instrumented using manual stainless steel files and irrigated by 2ml distilled water between each file, then were sectioned by longitudinal splitting of each tooth. The root halves were randomly assigned into 4 parallel groups (n=10) and immersed for 5 minutes with one of the following irrigants: Group I: 10 ml of 2.5% Sodium Hypochlorite (NaOCL), Group II: 10 ml of 17% ethylene diamine tetra-acetic acid (EDTA) followed by 10 ml of 2.5% NaOCL, Group III: 10 ml of 2.5% NaOCL followed by 10 ml of 2% chlorhexidine digluconate (CHX), Group IV: 10 ml of 2.5% NaOCL followed by 10 ml distilled water then were followed by 10ml of 2% CHX. Ten root halves from each group were prepared to measure dentin microhardness at baseline measurement and after treatment to determine the change in microhardness, using Vickers tester. RESULTS: Data were analysed using t-test, ANOVA test and Post Hoc test.Group II showed the highest percentage decrease in microhardness values, followed by group III, then group IV and the lowest was group I. All groups showed a significant difference between each other (P < 0.05), except group III and IV. The coronal third showed the highest percentage decrease with significant difference between apical and middle thirds (P < 0.05), in which there was no significant difference between them. CONCLUSIONS: CHX is the best final irrigant if there is excellent intermediate flush for prevention of its precipitation with NaOCL.The coronal third needs conservative approach as it is the most affected third.

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“…Chitosan showed a significant increase in the resistance to degradation of collagenase after dentin ocolagene is coated with nanoparticles of chitosan (CSnp). It also showed increase the microhardness of the root dentin layer [37], in addition, the chitosan modified with methacrylate is proposed as a component of an etch-and-rinse adhesive, a system to improve the durability of dental restorations [38]. In addition, the use of chitosan/riboflavin to modify collagen dentine, with the defined proportions, stabilizes the fibrillar network of collagen enhances resin infiltration and hybrid layer formation [39].…”

Section: Naturalmentioning

confidence: 99%

Dentin Biomodification Agents in Dentistry–A Critical Review

Freitas¹,

Ponte²,

Farias³

et al. 2019

ohdm

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Objective: To carry out a literature review on the dentin biomodification agents used in dental research. Methods: The PubMed database and collected literature were used as a resource for peer-reviewed articles to highlight the topics of dentin hierarchical structure, biomodification agents, and investigations of their laboratory and clinical applications. Results: Biomodification agents can be categorized as physical methods and chemical agents. Synthetic and naturally occurring chemical strategies present a distinctive mechanism of interaction with the tissue. Initially thought to be driven only by inter-or intra-molecular collagen-induced non-enzymatic collagen cross-linking, multiple interactions with other dentin components are fundamental for the long-term biomechanics and biostability of the tissue. Conclusion: Riboflavin is a physical agent that is difficult to obtain in industrial terms compared to natural extracts from plants such as proanthocyanidin that can be extracted from natural sources. Cardol and cardanol are industrial discard products and are a good choice for every day being produced on a large scale. Curcumin and chitosan have more accessibility in the extraction. Those of synthetic origin, such as glutaraldehyde have cytotoxic potential and carbodiimide has been a favorable substitute due to lower cytotoxic potential.

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Effect of phytic acid, ethylenediaminetetraacetic acid, and chitosan solutions on microhardness of the human radicular dentin

Cited by 32 publications

References 24 publications

Impact of Chitosan as Chelating Agent on Microhardness and Mineral Content of Intraradicular Dentin

Impact of Chitosan as Chelating Agent on Microhardness and Mineral Content of Intraradicular Dentin

Evaluation of the Microhardness of Root Canal Dentin After Different Irrigation Protocols (In Vitro Study)

Dentin Biomodification Agents in Dentistry–A Critical Review

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