Effect of pine bark extract (Pycnogenol<sup>®</sup>) on symptoms of knee osteoarthritis

Cisár, Peter; Jány, Richard; Waczulíková, Iveta; Sumegová, Katarína; Muchová, Jana; Vojtassák, J; Ďuračková, Zdeňka; Lisý, Miroslav; Rohdewald, Peter

doi:10.1002/ptr.2461

Cited by 72 publications

(57 citation statements)

References 17 publications

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“…This promising trial in a very common disease effecting millions of people needs further studies with large number of patients. Cisar et al (2008) studied the effect of PBE on knee osteoarthritis stages I and II in a double-blind, placebo-control trial treating 100 patients with 150 mg/day PBE for three months. After that patients filled the WOMAC questionnaire every 2 weeks reporting any change in the use of previously prescribed anti-inflammatory medication during the study period.…”

Section: Osteoarthritis and Pbementioning

confidence: 99%

A review on biological, nutraceutical and clinical aspects of French maritime pine bark extract

Maimoona

Naeem

Saddiqe

et al. 2011

Journal of Ethnopharmacology

151

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Section: Osteoarthritis and Pbementioning

confidence: 99%

A review on biological, nutraceutical and clinical aspects of French maritime pine bark extract

Maimoona

Naeem

Saddiqe

et al. 2011

Journal of Ethnopharmacology

151

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“…In the context of treatment of OA, inhibition of matrix metalloproteases (MMPs) is of great interest. After the intake of Pycnogenol ® , release of MMP9 from macrophages is inhibited (Cisar et al, 2006), thus blocking the destructive activity of MMP on cartilage.…”

Section: Introductionmentioning

confidence: 99%

Treatment of osteoarthritis with Pycnogenol^®. The SVOS (San Valentino osteo‐arthrosis study). evaluation of signs, symptoms, physical performance and vascular aspects

Belcaro

Cesarone

Errichi

et al. 2008

Phytotherapy Research

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The aim of this double-blind, placebo-controlled study was to evaluate the efficacy of 100 mg Pycnogenol daily (oral capsules) in a 3 month study in patients with osteoarthritis (OA). OA symptoms were evaluated by WOMAC scores, mobility by recording their walking performance (treadmill). Treatment (77 patients) and placebo group (79) were comparable for age, sex distribution, WOMAC scores, walking distances and use of antiinflammatory drugs. The global WOMAC score decreased by 56% (p < 0.05) in the treatment group versus 9.6% in the placebo group. Walking distance in the treadmill test was prolonged from 68 m at the start to 198 m after 3 months treatment (p < 0.05), under placebo, from 65 m to 88 m (NS). The use of drugs decreased by 58% in the treatment group (p < 0.05) versus 1% under placebo. Gastrointestinal complications decreased by 63% in the treatment group, but only 3% under placebo. Overall, treatment costs were reduced significantly compared with placebo. Foot edema was present in 76% of the patients of the treatment group at inclusion and in 79% of the controls. After 3 months edema decreased in 79% of Pycnogenol patients (p < 0.05) vs 1% in controls. In conclusion, Pycnogenol offers an option for reduction of treatment costs and side effects by sparing antiinflammatory drugs.

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“…and 3 other species) was performed using 5 investigated compounds and 12 selected peaks(peak No. 2,3,4,6,7,10,15,17,20,23,26,29, were bold in Table 1 ) as markers respectively (shown in Figure 5 ). Their results were very similar, which sort all samples into two clusters, Abies holophylla Maxim.…”

Section: Hierarchical Clustering Analysis (Hca)mentioning

confidence: 99%

“…Pine needle was first recorded in "Compendium of Materia Medica", and is widely used in China for treatment of rheumatism and joint pain (Raynal, 2007, Cisar et al, 2008, swelling and pain from injuries, night blindness, hypertension, neurasthenia and external use in treating chilblain (Meng et al, 2012, Suntar et al, 2012, Clark et al, 2014. Phytochemical studies showed abundant compounds presented in pine needle, such an essential oil, flavonoids, Shikimic acid, amino acids, lignin , Kwon et al,2010, Zhang and Wang, 2010, among which essential oil were considered to be the primary bioactive constituents.…”

Section: Introductionmentioning

confidence: 99%

Identification and Quantification of Pine Needle Essential Oil From Different Habitats and Species of China by Gc-MS and Gc Method

Yu¹,

Su²,

Li³

et al. 2017

Afr J Tradit Complement Altern Med

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Background: Fresh pine needles, which evergreen, renewable and can be collected at any time, have abundant essential oil. The pine needle essential oil possess various biological activities, including antimicrobial, antioxidant, anti-inflammatory, cardioprotective properties etc., and can be widely used as medicine or medical raw materials, fragrances etc. So in order to make full use of pine needle plant resources, especially essential oil, the identification and quantification of essential oil were investigated. Materials and Methods: GC-MS was used to identified compounds in pine needle essential oil of Pinus massoniana Lamb. from Zhejiang, and GC method was developed for determining 5 compounds (namely α-pinene, β-pinene, limonene, bornyl acetate, β-caryophyllene) in pine needle essential oil from different habitats of Pinus massoniana Lamb. and different species (Pinus koraiensis Sieb. et Zucc., Pinus sylvestris var. mongolica Litv., Abies holophylla Maxim.). Hierarchical clustering analysis (HCA) was used to evaluate homogeneity of pine needles in China. Results: 42 compounds(monoterpenes and sesquiterpenes) were identified by GC-MS, which accounted for 99.62% of total essential oil, particularly contained α-and β-pinene (45.23%). Quantification results showed content of bornyl acetate were the lowest, while content of α-pinene, β-pinene were all high except Sichuan, among them α-pinene were higher than β-pinene except for Shandong and Jiangsu, and total content of essential oil in Guangxi is the highest, Jiangsu was the lowest within Pinus massoniana from different habitats. Within pine needle from different species, the highest total content was Pinus koraiensis, the lowest was Pinus sylvestris, Interestingly, the highest content of bornyl acetate was Abies holophylla. By HCA, samples were sorted into two clusters, Abies holophylla and the other, that is Abies holophylla is different from Pinus massoniana, Pinus koraiensis and Pinus sylvestris. Pinus massoniana from Sichuan is different from other Pinus, in which limonene was the highest in all samples. Conclusions: Compounds of pine needle essential oil vary greatly between genus, while smaller between species, so composition differences among pine needle essential oil was related with genus and species. Abies holophylla is different from other pinus species, and Pinus massoniana from Sichuan is different from other habitats. Pine needle essential oil contains abundant α-and β-pinene, which can be used as an alternative raw materials source of pinene. And Abies holophylla and Pinus massoniana from Sichuan can become bornyl acetate and limonene alternative source of raw materials.

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Effect of pine bark extract (Pycnogenol^®) on symptoms of knee osteoarthritis

Abstract: Results show that Pycnogenol in patients with mild to moderate OA improves symptoms and is able to spare NSAIDs.

Cited by 72 publications

References 17 publications

A review on biological, nutraceutical and clinical aspects of French maritime pine bark extract

A review on biological, nutraceutical and clinical aspects of French maritime pine bark extract

Treatment of osteoarthritis with Pycnogenol^®. The SVOS (San Valentino osteo‐arthrosis study). evaluation of signs, symptoms, physical performance and vascular aspects

Identification and Quantification of Pine Needle Essential Oil From Different Habitats and Species of China by Gc-MS and Gc Method

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Effect of pine bark extract (Pycnogenol®) on symptoms of knee osteoarthritis

Abstract: Results show that Pycnogenol in patients with mild to moderate OA improves symptoms and is able to spare NSAIDs.

Cited by 72 publications

References 17 publications

A review on biological, nutraceutical and clinical aspects of French maritime pine bark extract

A review on biological, nutraceutical and clinical aspects of French maritime pine bark extract

Treatment of osteoarthritis with Pycnogenol®. The SVOS (San Valentino osteo‐arthrosis study). evaluation of signs, symptoms, physical performance and vascular aspects

Identification and Quantification of Pine Needle Essential Oil From Different Habitats and Species of China by Gc-MS and Gc Method

Contact Info

Product

Resources

About

Effect of pine bark extract (Pycnogenol^®) on symptoms of knee osteoarthritis

Treatment of osteoarthritis with Pycnogenol^®. The SVOS (San Valentino osteo‐arthrosis study). evaluation of signs, symptoms, physical performance and vascular aspects