Effect of pioglitazone, quercetin, and hydroxy citric acid on vascular endothelial growth factor messenger RNA (VEGF mRNA) expression in experimentally induced nonalcoholic steatohepatitis (NASH)

Surapaneni, Krishna Mohan; Veeraraghavan, Vishnu Priya; Jainu, Mallika

doi:10.3906/sag-1404-136

Cited by 8 publications

(3 citation statements)

References 10 publications

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“…EEGS treatment in HFD-treated rats exhibited significant suppression in expression of VEGF. This is consistent with previous observations Surapaneni et al (2015) who proved that quercetin downregulates VEGF expression more than hydroxy citric acid and pioglitazone in NASH rats model. Domitrović et al (2013) revealed the antioxidant, and antifibrotic prospect of rosmarinic acid in acute hepatic intoxication.…”

Section: Discussionsupporting

confidence: 93%

Ameliorative Effect of Garden Cress (Lepidium sativum L.) Seeds Ethanolic Extract on High Fat Diet-prompted Non-alcoholic Fatty Liver Disease in the Rat Model: Impact on 3-Hydroxy-3-methylglutaryl-Coenzyme A Reductase and Vascular Endothelial Growth Facto

Ibrahim¹,

Shalaby²,

Abdallah³

et al. 2020

Adv. Anim. Vet. Sci.

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Section: Discussionsupporting

confidence: 93%

Ameliorative Effect of Garden Cress (Lepidium sativum L.) Seeds Ethanolic Extract on High Fat Diet-prompted Non-alcoholic Fatty Liver Disease in the Rat Model: Impact on 3-Hydroxy-3-methylglutaryl-Coenzyme A Reductase and Vascular Endothelial Growth Facto

Ibrahim¹,

Shalaby²,

Abdallah³

et al. 2020

Adv. Anim. Vet. Sci.

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“…Contrary to this, VEGF expression is suppressed by EEFS treatment in AD-treated rats. This corresponds to the observation of Surapaneni et al (2015) who described the role of quercetin in minimizing VEGF expression in AD-fed rats. Fan et al (2017) concluded the anti-inflammatory role of catechins in bowel disease.…”

Section: Discussionsupporting

confidence: 89%

Immunomodulatory and Anti-angiogenic Properties of Linum usitatissium (flaxseed) Seeds Ethanolic Extract in Atherogenic Diet Treated Rats

Ibrahim¹,

Shalaby²,

Abdallah³

et al. 2020

Adv. Anim. Vet. Sci.

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We determined the cardioprotective impact of ethanolic flaxseed seeds extract through an assessment of its immunomodulatory and antiangiogenic characteristics in rats fed with an atherogenic diet. Group 1 fed on the standard diet. Groups 2 and 3 fed on an atherogenic diet (AD) for 12 weeks. Groups 3 and 4 daily supplemented with ethanolic extract of flaxseed seeds (EEFS) 400mg/kg b.w starting from 7 th week till the end of 12 th week. AD-fed rats had increased serum lipids, CRI-I, CRI-II, cardiac enzymes, and pro-inflammatory markers. Compared to the ADfed group, EEFS supplementation influenced hypo-lipidemic, anti-inflammatory, anti-angiogenic, and anti-atherogenic characteristics after AD-feeding. EEFS displayed antioxidant capacity in vitro and in vivo. Chromatographic analysis of EEFS demonstrated the presence of phenolic, flavonoid compounds, and vitamin C. The data concludes a safe application of EEFS in atherogenesis-induced cardiac disease management.

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“…Vascular endothelial growth factor (VEGF) has been found to play an important role in the development of liver fibrosis and liver neoplasms and may be inhibited by QE, as studied by Surapaneni et al . [ 96 ]…”

Section: Quercetin Liver Disease and Nafldmentioning

confidence: 99%

Nonalcoholic fatty liver disease

Sotiropoulou

Katsaros

Vailas

et al. 2021

Saudi Journal of Gastroenterology

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Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease, affecting almost one-third of the general population and 75% of obese patients with type 2 diabetes. The aim of this article is to review the current evidence concerning the role of quercetin, a natural compound and flavonoid, and its possible therapeutic effects on this modern-day disease. Despite the fact that the exact pathophysiological mechanisms through which quercetin has a hepatoprotective effect on NAFLD are still not fully elucidated, this review clearly demonstrates that this flavonoid has potent antioxidative stress action and inhibitory effects on hepatocyte apoptosis, inflammation, and generation of reactive oxygen species, factors which are linked to the development of the disease. NAFLD is closely associated with increased dietary fat consumption, especially in Western countries. The hepatoprotective effect of quercetin against NAFLD merits serious consideration and further validation by future studies.

show abstract

Effect of pioglitazone, quercetin, and hydroxy citric acid on vascular endothelial growth factor messenger RNA (VEGF mRNA) expression in experimentally induced nonalcoholic steatohepatitis (NASH)

Cited by 8 publications

References 10 publications

Ameliorative Effect of Garden Cress (Lepidium sativum L.) Seeds Ethanolic Extract on High Fat Diet-prompted Non-alcoholic Fatty Liver Disease in the Rat Model: Impact on 3-Hydroxy-3-methylglutaryl-Coenzyme A Reductase and Vascular Endothelial Growth Facto

Ameliorative Effect of Garden Cress (Lepidium sativum L.) Seeds Ethanolic Extract on High Fat Diet-prompted Non-alcoholic Fatty Liver Disease in the Rat Model: Impact on 3-Hydroxy-3-methylglutaryl-Coenzyme A Reductase and Vascular Endothelial Growth Facto

Immunomodulatory and Anti-angiogenic Properties of Linum usitatissium (flaxseed) Seeds Ethanolic Extract in Atherogenic Diet Treated Rats

Nonalcoholic fatty liver disease

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