Effect of Polyamines on Autohemolysis: Studies on Normal and Thalassemic Children

Vanella, Vito; Rizza, V.; Volti, Li; Pinturo, R.; Musumeci, Sonia Nunzialfina; Mollica, F

doi:10.1159/000207403

Cited by 6 publications

(2 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In fact, polyamines might act as scavengers of the free radicals themselves, because interactions between polyamines and the active oxygen species have been found (31). Therefore, in addition to their known functions, polyamines are thought to act as antioxidants in protecting nucleic acids, membranes and other components from free-radical damage (10,32,33). These studies emphasize a possible correlation between polyamines and the ability of various species to survive 02 toxicity (25).…”

Section: Discussionmentioning

confidence: 99%

Acute and chronic hyperbaric oxygen exposure in humans: effects on blood polyamines, adrenocorticotropin and β-endorphin

Casti

Orlandini²,

Troglio³

et al. 1993

Acta Endocrinologica

View full text Add to dashboard Cite

P. Acute and chronic hyperbaric oxygen exposure in humans: effects on blood polyamines, adrenocorticotropin and /?-endorphin. Acta Endocrinol 1993;129:436-41. ISSN 0001-5598. Plasma \g=b\-endorphin,adrenocorticotropin (ACTH) and blood polyamine (spermidine and spermine) concentrations were evaluated in healthy adult male athletes undergoing hyperbaric oxygen exposure for 10 days (2.8 atm, 100% O2, 60 min daily). In the "acute phase", corresponding to the first day of treatment, and in the "acute in the chronic phase", corresponding to the values obtained on the 5th and 10th days after 60 min of hyperbaric O2, both ACTH and \g=b\-endorphin levels increased significantly, whereas no variations were observed for polyamine concentrations. In the "chronic phase", corresponding to the basal values of the 5th and 10th days of treatment, we found a different pattern. In fact, the concentration of polyamines showed a remarkable enhancement, while ACTH and \ g = b \ \ x = r e q -\ endorphin levels remained unchanged. No significant variations were observed during hyperbarism with air. These results demonstrate different modifications of polyamines and \g=b\-endorphinand ACTH in subjects submitted to hyperbaric oxygen exposure.

show abstract

Section: Discussionmentioning

confidence: 99%

Acute and chronic hyperbaric oxygen exposure in humans: effects on blood polyamines, adrenocorticotropin and β-endorphin

Casti

Orlandini²,

Troglio³

et al. 1993

Acta Endocrinologica

View full text Add to dashboard Cite

show abstract

“…It has been suggested that polyamines play an important role as cellular antioxidants and membrane stabilizers (13). Therefore, the high levels of polyamines found in the myopathic subjects could have the significance of a compensatory phenomenon in an effort to protect the cellular membrane from its involvement.…”

Section: Discussionmentioning

confidence: 99%

Increased Erythrocytic Spermine in Duchenne Muscular Dystrophy

et al. 1980

View full text Add to dashboard Cite

The influence of polyamine-nucleic acid complexes on Fe2+ autoxidation

Tadolini

1988

Mol Cell Biochem

View full text Add to dashboard Cite

Polyamines are able to affect Fe2+ autoxidation in the presence of suitable low molecular weight phosphorus-containing compounds; the inhibitory effect exerted by polyamines is directly related to their ability to bind phosphorus-containing compounds. It is well known that polyamines, as polycations at physiological pH, bind strongly to nucleic acids. In this paper it is shown that polyamines, also in the presence of nucleic acids, inhibit Fe2+ autoxidation and thus depress the generation of free oxygen radicals. Most of the nucleic acids tested inhibited Fe2+ autoxidation although the concentration which causes half maximal effect differs. Polyamine effect on Fe2+ autoxidation varies greatly depending on the single or double stranded nature of the nucleic acid. In the present of single stranded nucleic acids, spermine and spermidine potentiate the inhibition of Fe2+ autoxidation by these nucleic acids. A relationship exists between the ability of spermine to interact with single stranded nucleic acids and to inhibit Fe2+ autoxidation in their presence. When double stranded nucleic acids are present, polyamines reverse the inhibition of Fe2+ autoxidation exerted by these nucleic acids. Molecular mechanisms are proposed to explain these experimental results. The hypothesis that polyamines may inhibit oxidative damage caused to nucleic acids by Fe2+ autoxidation, is also discussed.

show abstract

Effect of Polyamines on Autohemolysis: Studies on Normal and Thalassemic Children

Cited by 6 publications

References 3 publications

Acute and chronic hyperbaric oxygen exposure in humans: effects on blood polyamines, adrenocorticotropin and β-endorphin

Acute and chronic hyperbaric oxygen exposure in humans: effects on blood polyamines, adrenocorticotropin and β-endorphin

Increased Erythrocytic Spermine in Duchenne Muscular Dystrophy

The influence of polyamine-nucleic acid complexes on Fe2+ autoxidation

Contact Info

Product

Resources

About