Effect of polybrominated diphenyl ether congeners on placental cytokine production

Arita, Yuko; Yeh, Corinne; Thoma, Theodosia; Getahun, Darios; Menon, Ramkumar; Peltier, Morgan R.

doi:10.1016/j.jri.2017.12.002

Cited by 24 publications

(19 citation statements)

References 36 publications

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“…Polybrominated diphenyl ethers (PBDEs) are a public health concern for pregnant women worldwide due to their developmental health impacts and widespread use as flame retardant chemicals in consumer and industrial products, including furniture, electronics, building materials, and child care articles 1 . PBDEs are biologically active endocrine disrupting compounds that can interfere with endogenous hormone activity, immune system function, and fetal brain development during pregnancy 2 – 4 . For 30 years, California had the strictest flammability standard in the world, with CA’s Technical Bulletin 117 (TB117) requiring the use of polyurethane foam in upholstered furniture and children’s products that was able to withstand an open flame for up to 12 seconds 5 .…”

Section: Introductionmentioning

confidence: 99%

Racial/ethnic and geographic differences in polybrominated diphenyl ether (PBDE) levels across maternal, placental, and fetal tissues during mid-gestation

Varshavsky

Sen

Robinson

et al. 2020

Sci Rep

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Prenatal polybrominated diphenyl ether (PBDE) exposures are a public health concern due to their persistence and potential for reproductive and developmental harm. However, we have little information about the extent of fetal exposures during critical developmental periods and the variation in exposures for groups that may be more highly exposed, such as communities of color and lower socioeconomic status (SES). To characterize maternal-fetal PBDE exposures among potentially vulnerable groups, PBDE levels were examined in the largest sample of matched maternal serum, placenta, and fetal liver tissues during mid-gestation among a geographically, racially/ethnically, and socially diverse population of pregnant women from Northern California and the Central Valley (n = 180; 2014-16). Maternal-fetal PBDE levels were compared to population characteristics using censored Kendall's tau correlation and linear regression. PBDEs were commonly detected in all biomatrices. Before lipid adjustment, wet-weight levels of all four PBDE congeners were highest in the fetal liver (p < 0.001), whereas median PBDE levels were significantly higher in maternal serum than in the fetal liver or placenta after lipid-adjustment (p < 0.001). We also found evidence of racial/ethnic disparities in PBDE exposures (Non-Hispanic Black > Latina/Hispanic > Non-Hispanic White > Asian/ Pacific Islander/Other; p < 0.01), with higher levels of BDE-100 and BDE-153 among non-Hispanic Black women compared to the referent group (Latina/Hispanic women). In addition, participants living in Fresno/South Central Valley had 34% (95% CI: − 2.4 to 84%, p = 0.07) higher wet-weight levels of BDE-47 than residents living in the San Francisco Bay Area. PBDEs are widely detected and differentially distributed in maternal-fetal compartments. Non-Hispanic Black pregnant women and women from Southern Central Valley geographical populations may be more highly exposed to PBDEs. Further research is needed to identify sources that may be contributing to differential exposures and associated health risks among these vulnerable populations.

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Section: Introductionmentioning

confidence: 99%

Racial/ethnic and geographic differences in polybrominated diphenyl ether (PBDE) levels across maternal, placental, and fetal tissues during mid-gestation

Varshavsky

Sen

Robinson

et al. 2020

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Similarly, TCDD increased bacteriastimulated PGE 2 and COX-2 gene expression and decreased IL-10 secretion (Peltier et al, 2013). Notably, the PBDE and TCDD effects were observed in the absence of impacts on explant viability and in placenta tissue obtained from both term (Arita et al, 2018c) and preterm (Peltier et al, 2012(Peltier et al, , 2013 stages of pregnancy, suggesting that immunomodulatory effects can occur throughout gestation. In addition, tributyltin enhanced E. coli-stimulated IL-6 release from placental explants (Arita et al, 2018a).…”

Section: Toxicant-pathogen Co-treatment Leads To Enhanced Inflammationmentioning

confidence: 94%

“…Some toxicants have been shown to enhance pathogenstimulated oxidative stress pathways and pro-inflammatory responses in gestational tissues. For example, some PBDEs increased E. coli-stimulated IL-1β and IL-6 secretion and COX-2 expression, as well as reduced E. coli-stimulated IL-10 release in human placental explants (Peltier et al, 2012;Arita et al, 2018c). Similarly, TCDD increased bacteriastimulated PGE 2 and COX-2 gene expression and decreased IL-10 secretion (Peltier et al, 2013).…”

Section: Toxicant-pathogen Co-treatment Leads To Enhanced Inflammationmentioning

confidence: 99%

Toxicant Disruption of Immune Defenses: Potential Implications for Fetal Membranes and Pregnancy

2020

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In addition to providing a physical compartment for gestation, the fetal membranes (FM) are an active immunological barrier that provides defense against pathogenic microorganisms that ascend the gravid reproductive tract. Pathogenic infection of the gestational tissues (FM and placenta) is a leading known cause of preterm birth (PTB). Some environmental toxicants decrease the capacity for organisms to mount an immune defense against pathogens. For example, the immunosuppressive effects of the widespread environmental contaminant trichloroethylene (TCE) are documented for lung infection with Streptococcus zooepidemicus. Group B Streptococcus (GBS; Streptococcus agalactiae) is a bacterial pathogen that is frequently found in the female reproductive tract and can colonize the FM in pregnant women. Work in our laboratory has demonstrated that a bioactive TCE metabolite, S-(1, 2-dichlorovinyl)-L-cysteine (DCVC), potently inhibits innate immune responses to GBS in human FM in culture. Despite these provocative findings, little is known about how DCVC and other toxicants modify the risk for pathogenic infection of FM. Infection of the gestational tissues (FM and placenta) is a leading known cause of PTB, therefore toxicant compromise of FM ability to fight off infectious microorganisms could significantly contribute to PTB risk. This Perspective provides the current status of understanding of toxicant-pathogen interactions in FM, highlighting knowledge gaps, challenges, and opportunities for research that can advance protections for maternal and fetal health.

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“…Eslami et al (2016) found a significant association between total PBDEs and preeclampsia among first mothers in Iran, while no association was detected in a prospective U.S. cohort [29,30]. In mice and/or human cell lines, PBDEs alter hormone production [31], elicit inflammation [32][33][34], and promote oxidative stress [32,[35][36][37][38][39]. Data from in vitro studies supports the hypothesis that PBDEs disrupt trophoblast function and placentation.…”

Section: Introductionmentioning

confidence: 91%

Association of polybrominated diphenyl ether (PBDE) levels with biomarkers of placental development and disease during mid-gestation

et al. 2020

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Background: Polybrominated diphenyl ether (PBDE) exposures have been associated with adverse pregnancy outcomes. A hypothesized mechanism is via alterations in placental development and function. However, we lack biomarkers that can be used as early indicators of maternal/fetal response to PBDE exposures and/or perturbations in placental development or function. Methods: To evaluate the relationship between PBDE levels and placental biomarkers during mid-gestation of human pregnancy (n = 62), we immunolocalized three molecules that play key roles in cytotrophoblast (CTB) differentiation and interstitial/endovascular uterine invasion-integrin alpha-1 (ITGA1), vascular endothelial-cadherin (CDH5), and metalloproteinase-1 (MMP1)-and assessed three morphological parameters as potential indicators of pathological alterations using H&E-stained tissues-leukocyte infiltration, fibrinoid deposition, and CTB endovascular invasion. We evaluated associations between placental PBDE levels and of biomarkers of placental development and disease using censored Kendall's tau correlation and linear regression methods. Results: PBDEs were detected in all placental samples. We observed substantial variation in antigen expression and morphological endpoints across placental regions. We observed an association between PBDE concentrations and immunoreactivity of endovascular CTB staining with anti-ITGA1 (inverse) or interstitial CTBs staining with anti-CDH5 (positive).

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Effect of polybrominated diphenyl ether congeners on placental cytokine production

Cited by 24 publications

References 36 publications

Racial/ethnic and geographic differences in polybrominated diphenyl ether (PBDE) levels across maternal, placental, and fetal tissues during mid-gestation

Racial/ethnic and geographic differences in polybrominated diphenyl ether (PBDE) levels across maternal, placental, and fetal tissues during mid-gestation

Toxicant Disruption of Immune Defenses: Potential Implications for Fetal Membranes and Pregnancy

Association of polybrominated diphenyl ether (PBDE) levels with biomarkers of placental development and disease during mid-gestation

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