Effect of Polydatin on Neurological Function and the Nrf2 Pathway during Intracerebral Hemorrhage

Zhao, Xiumin; Qin, Jingxu; Li, Haitao; Feng, Xiaoshan; Lv, Yongtao; Yang, Jianjun

doi:10.1007/s12031-020-01546-3

Cited by 13 publications

(12 citation statements)

References 14 publications

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“…Polydatin significantly decreased the modified neurological severity score (mNSS) and water brain content in a rat model of ICH. A significant decrease in the content of neuron‐specific enolase (NSE) was observed in animal serum treated with polydatin compared with the ICH model group (Zhao et al, 2020). NSE is an enzyme that can be used to indicate the degree of nerve injury induced by cerebral hemorrhage (Fizazi et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

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Polydatin as a therapeutic alternative for central nervous system disorders: A systematic review of animal studies

Schimith

Santos

Arbo

et al. 2022

Phytotherapy Research

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Polydatin, or piceid, is a natural stilbene found in grapes, peanuts, and wines. Polydatin presents pharmacological activities, including neuroprotective properties, exerting preventive and/or therapeutic effects in central nervous system (CNS) disorders. In the present study, we summarize and discuss the neuroprotective effects of polydatin in CNS disorders and related pathological conditions in preclinical animal studies. A systematic review was performed by searching online databases, returning a total of 110 records, where 27 articles were selected and discussed here. The included studies showed neuroprotective effects of polydatin in experimental models of neurological disorders, including cerebrovascular disorders, Parkinson's disease, traumatic brain injuries, diabetic neuropathy, glioblastoma, and neurotoxicity induced by chemical agents. Most studies were focused on stroke (22.2%) and conducted in male rodents. The intervention protocol with polydatin was mainly acute (66.7%), with postdamage induction treatment being the most commonly used regimen (55.2%). Overall, polydatin ameliorated behavioral dysfunctions and/or promoted neurological function by virtue of its antioxidant and antiinflammatory properties. In summary, this review offers important scientific evidence for the neuroprotective effects and distinct pharmacological mechanisms of polydatin that not only enhances the present understanding but is also useful for the development of future preclinical and clinical investigations.

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Section: Discussionmentioning

confidence: 99%

“…Likewise, ICH‐induced rats showed increased expression of genes and proteins related to antioxidant defences, such as Nrf2, HO‐1, NQO1, and Kelch‐like ECH‐associated protein 1 (Keap1). Polydatin treatment ameliorated oxidative stress, decreased the contents of NO and MDA, and increased SOD, GSSG, and GSH levels (Zhao et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Polydatin as a therapeutic alternative for central nervous system disorders: A systematic review of animal studies

Schimith

Santos

Arbo

et al. 2022

Phytotherapy Research

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“…Replenishment of GSH can be understood in the context that PD has probably improved GSH homeostasis through increased tissue cysteine and GSH efflux and increased recycling of GSH. [38] Long et al [39] reported that the structure of polyphenol makes it possible for PD to have strong antioxidant activity. The antioxidant effects of PD were previously demonstrated in multiple models of pulmonary injury [31,40,41] Another main event involved in MTX lung toxicity is the inflammatory process.…”

Section: Discussionmentioning

confidence: 99%

Polydatin combats methotrexate‐induced pulmonary fibrosis in rats: Involvement of biochemical and histopathological assessment

Ali

Ahmed

El‐Raouf

et al. 2022

J Biochem & Molecular Tox

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Polydatin (PD) is a polyphenolic compound found naturally in many fruits such as grapes. It has anti‐oxidant and anti‐inflammatory activities that are of paramount importance for its pharmacological actions. This study aimed to explore possible protective effects of PD against methotrexate (MTX)‐induced pulmonary fibrosis in rats. A single oral dose of MTX (14 mg/kg) per week for 2 weeks caused a significant decrease in glutathione (GSH) content with a marked increase in transforming growth factor‐beta (TGF‐β), alpha‐smooth muscle actin (α‐SMA), pulmonary content of malondialdehyde (MDA), interleukin‐1β (IL‐1β), Hydroxyproline, tumor necrosis factor‐alpha (TNF‐α), and 8‐hydroxy‐2'‐deoxyguanosine (8‐OHdG) as compared with the control group. Contrarily, daily administration of PD (25, 50, and 100 mg/kg, p.o.) for 14 days concomitantly with MTX ameliorated MTX‐induced pulmonary fibrosis as indicated by mitigation of the previously mentioned biochemical parameters and histopathological changes in a dose‐dependent manner. In conclusion, the protective effect of PD against pulmonary fibrosis induced by MTX in rats might be attributed to its anti‐oxidant, anti‐inflammatory as well as anti‐fibrotic effects.

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“…Cerebral haemorrhage is also a widespread brain injury. PD prevented cerebral haemorrhage by regulating the expression of the Nrf2‐ARE pathway and decreasing oxidative stress (X. Zhao et al, 2020). PD reduced D‐GAL‐induced brain injury via antioxidant and antiinflammatory effects (L.‐Q.…”

Section: Pharmacological Effectsmentioning

confidence: 99%

Old dog, new tricks: Polydatin as a multitarget agent for current diseases

Jiang

et al. 2021

Phytotherapy Research

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Polydatin (PD) is a natural single‐crystal product that is primarily extracted from the traditional plant Polygonum cuspidatum Sieb. et Zucc. Early research showed that PD exhibited a variety of biological activities. PD has attracted increasing research interest since 2014, but no review comprehensively summarized the new findings. A great gap between its biological activities and drug development remains. It is necessary to summarize new findings on the pharmacological effects of PD on current diseases. We propose that PD will most likely be used in cardiac and cerebral ischaemia/reperfusion‐related diseases and atherosclerosis in the future. The present work classified these new findings according to diseases and summarized the main effects of PD via specific mechanisms of action. In summary, we found that PD played a therapeutic role in a variety of diseases, primarily via five mechanisms: antioxidative effects, antiinflammatory effects, regulation of autophagy and apoptosis, maintenance of mitochondrial function, and lipid regulation.

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Effect of Polydatin on Neurological Function and the Nrf2 Pathway during Intracerebral Hemorrhage

Cited by 13 publications

References 14 publications

Polydatin as a therapeutic alternative for central nervous system disorders: A systematic review of animal studies

Polydatin as a therapeutic alternative for central nervous system disorders: A systematic review of animal studies

Polydatin combats methotrexate‐induced pulmonary fibrosis in rats: Involvement of biochemical and histopathological assessment

Old dog, new tricks: Polydatin as a multitarget agent for current diseases

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