Effect of polydeoxyribonucleotide injection on pes anserine bursitis

Abstract

Rationale:Pes anserine (PA) bursitis is an inflammatory condition of the medial knee. The PA bursa becomes more painful when infected, damaged, or irritated. Although various treatment options have been attempted to treat PA bursitis, optimal treatments are still debated. This study aims to investigate the effect of polydeoxyribonucleotide (PDRN) injection on reducing pain and inflammation in a patient presenting with PA bursitis.Patient concerns:A 50-year-old female patient was admitted to our pain clinic with symptoms of tenderness and pain over the medial knee. Physical examination revealed the pain to be located over the proximal medial tibia at the insertion of the conjoined tendons of the PA. The knee had lost its range of movement and strength, and resisted knee flexion.Diagnoses:She was diagnosed as having PA bursitis.Interventions:Ultrasound guided PA bursa injection was carried out.Outcomes:Follow-up for the patient was more than eight months. She showed good improvement in PA bursitis without any complications.Lessons:This is the first successful report of successful PDRN injection for PA bursa.

Applications of Marine Organism-Derived Polydeoxyribonucleotide: Its Potential in Biomedical Engineering

“…Furthermore, only 3 studies used PDRN extracted from Acipenser sinensis (As-PDRN). Sturgeons ( A. sinensis ), a species with the fastest growth rate among the three sources, is a novel PDRN extraction source used by Veritas in Italy [ 12 , 13 , 14 , 15 ]. Pharmaresearch Product (Pangyo, Korea), Mastelli Srl (San Remo, Italy), and Veritas (Brescia, Italy) exclusively provide Om-PDRN, PDRN extracted from O. keta (Ok-PDRN), and As-PDRN ( Figure 3 B).…”

Full recovery of near complete tear of anterior cruciate ligament without surgery: a case report

“…[ 11 , 12 ] PDRN repairs and regenerates cellular damage by interacting with A2 purinergic receptor and stimulating the production of vascular endothelial growth factors. [ 11 ] PDRN has recently found wide application throughout the medical field: [ 13 ] not only in DM ulcer and cosmetics, but also in musculoskeletal areas. Even though PDRN does not seem to have an equivalent persistence effect compared to triamcinolone, considering the systemic side effects of steroids, particularly in patients with diabetes or metabolic syndrome, it appears that PDRN is worthwhile as an option for the treatment of hemiplegic shoulder pain.…”

“…Even though PDRN does not seem to have an equivalent persistence effect compared to triamcinolone, considering the systemic side effects of steroids, particularly in patients with diabetes or metabolic syndrome, it appears that PDRN is worthwhile as an option for the treatment of hemiplegic shoulder pain. [ 14 ] Mun et al [ 13 ] reported the effectiveness of PDRN injection on pes anserinus bursitis. Lim et al [ 11 ] reported the effectiveness of PDRN injection in posterior tibial tendon dysfunction patients undergoing ankle syndesmotic surgery.…”

Polydeoxyribonucleotide Regulation of Inflammation

“…Ultrasound-guided PA bursa injection of PDRN significantly reduced pain at the 2-week follow-up visit, and complete functional recovery was achieved at the 8-month follow-up examination. 75 Numerous studies have confirmed the efficacy of PDRN in reducing pain and symptoms of inflammation in tendinopathy, a musculoskeletal disorder for which an optimal treatment has not yet been established. 76 Glucocorticoids represent the most common treatment choice for this pathology.…”